Vitamin E Supplementation Improves Cell-Mediated Immunity and Oxidative Stress of Asian Men and Women

Lee, C Y; Wan, Jinjuan

doi:10.1093/jn/130.12.2932

Cited by 103 publications

(83 citation statements)

References 31 publications

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“…Taken together, these results show that vitamin E did not have any significant effect on immune modulation in healthy young subjects, unlike as reported in the Lee & Wan (21) study. The sample number used in the present study is similar, if not higher, than that used in the Lee & Wan (21) study.…”

Section: Discussioncontrasting

confidence: 67%

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Daily supplementation of tocotrienol-rich fraction or α-tocopherol did not induce immunomodulatory changes in healthy human volunteers

et al. 2008

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Vitamin E is divided into two subgroups; tocopherols and tocotrienols. Both have protective roles in biological systems. The present study was conducted to compare the effect of short-term supplementation at 200 mg/d of either a-tocopherol or a tocotrienol-rich fraction (TRF) from palm oil on immune modulation and plasma vitamin E levels in normal healthy Asian volunteers. In a randomised, double-blind placebo-controlled trial conducted, fifty-three healthy volunteers aged 20 -50 years were recruited based on the study's inclusion and exclusion criteria. They were randomly assigned into three groups, i.e. two experimental groups that received daily supplementation at 200 mg of either a-tocopherol or the TRF, and the control group that received a placebo. Blood was drawn on days 0, 28 and 56 for several laboratory analyses. Differences in the production of IL-4 or interferon-g by concanavalin A-stimulated lymphocytes isolated from these volunteers were not significant (P. 0·05). There were no significant differences observed in immune parameters between the healthy volunteers who received daily supplementation with either a-tocopherol or the TRF. As these observations were made in the absence of any immunogenic challenge, we feel it would be of benefit to study if there would be any differences observed when an immunogenic challenge such as vaccination were introduced.

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Section: Discussioncontrasting

confidence: 67%

“…The sample number used in the present study is similar, if not higher, than that used in the Lee & Wan (21) study. However, the lack of statistical significance could still be due to sample size, differences in the population or nutrition amongst the volunteers.…”

Section: Discussionmentioning

confidence: 90%

Daily supplementation of tocotrienol-rich fraction or α-tocopherol did not induce immunomodulatory changes in healthy human volunteers

et al. 2008

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“…2, No. 6; and reducing the risk of cancer (Lee et al, 2000). However, -tocopherol is regarded as the most active and predominant form (Bender & Mayes, 2003).…”

Section: Tocochromanol Contents In the Rice Bran Cultivarsmentioning

confidence: 99%

Vitamin E Profiles and Triacylglycerol Molecular Species of Colored Rice Bran Cultivars at Different Degree of Milling

Yoshida¹,

Kanamori²,

Yoshida³

et al. 2013

JFR

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The objective of this study was to evalute the tocochromanol distributions, lipid components and molecular species of triacylglycerols (TAG) in three colored rice bran cultivars. The dominant tocochromanol were -tocotrienol, -tocopherol and -tocotrienol with smaller amounts of -tocopherol, -tocopherol and -tocotrienol. These lipids comprised mainly TAG (78.0-81.6 wt%), free fatty acids (FFA: 5.6-8.8 wt%), and phospholipids (PL: 6.3-7.0 wt%), while other components were present in minor proportions (0.4-2.3 wt%). Sixteen different TAG molecular species were detected and quantified by successive applications of AgNO 3 -TLC and GC. The major TAG molecular species were SM 2 (6.1-9.8%), S 2 D (4.8-7.3%)，M 3 (16.4-18.7%), SMD (6.2-9.2%), SD 2 (6.5-9.5%), SMT (6.3-7.7%), M 2 D (12.3-15.5%.), MD 2 (8.4-10.4%), SDT (4.3-5.4%) and D 3 (10.2-15.2%) (where S, M, D, and T denote saturated FA, monoene, diene, and triene, respectively). The results showed that colored rice bran lipids contain large amounts of nutraceutical with proven positive health effects.

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“…Shimura et al [3] reported the depression of lymphocyte functions by lipid peroxidation induced by cumene hydroperoxide in rats' spleenocytes. Lee and Wan [4] reported that the short term supplementation of 233 mg of vitamin E to healthy subjects can modulate cell-mediated immunity and reduce oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Effect of Oxidized Phosphatidylcholine on Biomarkers of Oxidative Stress in Rats

Al-Orf

2011

Ind J Clin Biochem

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In this study it was planned to investigate the effect of oxidized phosphatidylcholine (derived from egg) feeding on lipid peroxidation of different tissues in rats. Male Wistar albino rats were fed oxidized and unoxidized phosphatidylcholine for 2 and 4 weeks, respectively. During the period of study food intake and body weights of animals increased gradually. Animals fed oxidized phosphatidylcholine for 2 and 4 weeks showed 33 and 15% spontaneous hemolysis of red blood cells in vitro. Under identical experimental conditions animals given unoxidized phosphatidylcholine showed 14.5 and 13.4% hemolysis for 2 and 4 week's period, respectively. Thiobarbituric acid reactive substances (TBARS) level in thymus, spleen, kidney, heart, liver and lung significantly increased in rats given oxidized phosphatidylcholine as compared to unoxidized group. Furthermore, in oxidized phosphatidylcholine group TBARS values in kidney, liver and lungs continued to rise for 4 weeks of treatment while TBARS level in heart, spleen and thymus was found to be decreased at the end of 4 weeks of oxidized phosphatidylcholine feeding. Plasma triacylglycerol and cholesterol was found to increase in rats who had received oxidized phosphatidylcholine for 2 weeks. These findings suggest that excess and persistent intake of oxidized phosphatidylcholine can cause significant damage to organs.

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Vitamin E Supplementation Improves Cell-Mediated Immunity and Oxidative Stress of Asian Men and Women

Cited by 103 publications

References 31 publications

Daily supplementation of tocotrienol-rich fraction or α-tocopherol did not induce immunomodulatory changes in healthy human volunteers

Daily supplementation of tocotrienol-rich fraction or α-tocopherol did not induce immunomodulatory changes in healthy human volunteers

Vitamin E Profiles and Triacylglycerol Molecular Species of Colored Rice Bran Cultivars at Different Degree of Milling

Effect of Oxidized Phosphatidylcholine on Biomarkers of Oxidative Stress in Rats

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