Vitamin E Supplementation Enhances Lipid Oxidative Stability via Increasing Vitamin E Retention, Rather Than Gene Expression of MAPK-Nrf2 Signaling Pathway in Muscles of Broilers

Xu, Lei; Wang, Jing; Zhang, Haijun; Wu, Shu‐geng; Yue, Hui; Wan, Xiaoli; Yang, Huajun; Wang, Zhi‐yue; Qi, Guang‐hai

doi:10.3390/foods10112555

Cited by 4 publications

(1 citation statement)

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“…For example, research has shown that supplementing animal diets with vitamin E can increase the vitamin E content of meat, milk, and eggs (Table 5), improving their nutritional value for consumers [4]. Furthermore, vitamin E has been proven to have a protective effect against lipid oxidation, which can cause off-flavors and reduce the shelf life of animal-derived foods [115][116][117][118]. Notably, vitamin E indirectly influences lamb aroma development by mitigating protein and lipid oxidation [116].…”

Section: Current Status and Future Research Of Vitamin E In Animal Nu...mentioning

confidence: 99%

A Century of Vitamin E: Early Milestones and Future Directions in Animal Nutrition

Shastak,

Obermueller-Jevic,

Pelletier

2023

Agriculture

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Vitamin E, consisting of four tocopherols and four tocotrienols, with α-tocopherol as the most biologically active form, has a significant history in scientific research. It was first identified in the 1920s for its role in preventing neonatal mortality in rats. Over time, its chemical structure was elucidated, and its importance in the immune system, skin health, anti-inflammatory properties, and hormonal balance was revealed. Vitamin E production has evolved from natural sourcing to efficient synthesis with standardized potency units. Initially, animal studies focused on reproductive health and growth disorders, but later research highlighted vitamin E’s role in preventing encephalomalacia in domestic fowl and muscular dystrophy in various animals. Today, vitamin E is commonly used as a feed additive to enhance animal health and immune function. Despite substantial knowledge about its role in animal nutrition, several questions remain unanswered. Current research seeks to determine optimal supplementation levels, interactions with other nutrients, impacts on gene expression, cell signaling, and communication, as well as the effects of high dosages in livestock. Vitamin E continues to be a crucial component in improving animal health, and ongoing research aims to uncover its benefits and mechanisms of action further.

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Section: Current Status and Future Research Of Vitamin E In Animal Nu...mentioning

confidence: 99%

A Century of Vitamin E: Early Milestones and Future Directions in Animal Nutrition

Shastak,

Obermueller-Jevic,

Pelletier

2023

Agriculture

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Protective effects of dietary dimethyl itaconate supplementation on oxidative stress, inflammation, and apoptosis in broilers under chronic heat stress

Wang,

Yang,

Huang

et al. 2023

Journal of Animal Science

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This study was conducted to evaluate the effects of dietary dimethyl itaconate (DI) supplementation on oxidative stress, inflammation, and apoptosis in broilers under chronic heat stress (HS). Twenty-one-day-old male Ross 308 broilers (n = 120) were randomly allocated to 5 groups: a control group, HS group, HS + 50 mg/kg DI group, HS + 150 mg/kg DI group, and HS + 200 mg/kg DI group. The birds in the control group received the basal diets and were maintained at 21 ± 1 °C for 24 h daily. The birds in the HS group and HS + DI groups were raised at 32 ± 1 °C for 8 h daily and received basal diets containing DI at the indicated dose (0, 50, 150, or 200 mg/kg). The results showed that the contents of alanine aminotransferase, aspartate aminotransferase, and malondialdehyde (MDA) in serum were markedly elevated by exposure to chronic HS (P < 0.01), and this elevation was alleviated by 150 and 200 mg/kg DI supplementation (P < 0.05). Chronic HS-induced declines (P < 0.05) in total antioxidant capacity (T-AOC) and activities of peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) in serum were markedly attenuated after 200 mg/kg DI treatment in broilers (P < 0.05). Moreover, broilers subjected to chronic HS exhibited higher contents of MDA, protein carbonyl, and hydrogen peroxide (P < 0.01), but lower T-AOC and activities of antioxidant enzymes (P < 0.05), as well as reduced inhibition of superoxide and hydroxyl free radicals (P < 0.01) in the liver compared to the control group; these changes were effectively mitigated by treatment with 200 mg/kg DI in broilers (P < 0.05). In addition, 50-200 mg/kg DI effectively ameliorated chronic HS-stimulated upregulation of the mRNA levels of pro-inflammatory mediators in the livers of broilers (P < 0.01). Dietary supplementation with 150 and 200 mg/kg DI significantly alleviated chronic HS challenge-induced upregulation of the mRNA levels of Bcl-2-associated X, caspase 3, and caspase 9 (P < 0.01), but downregulation of Bcl-2 mRNA levels (P < 0.01) in broilers (P < 0.05). Importantly, chronic HS-induced downregulation of the mRNA or protein levels of nuclear factor (erythroid-derived 2)-like 2 (NRF-2), NADPH quinone acceptor oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), SOD2, or glutathione-S-transferases (GST) (P < 0.01) was markedly improved by 150 and 200 mg/kg DI (P < 0.05). The above results indicated that DI can ameliorate oxidative stress, inflammation, and apoptosis in broilers under chronic HS.

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A century of vitamin E: Early milestones and future directions in animal nutrition

Shastak¹,

Obermueller-Jevic²,

Pelletier³

2023

Preprint

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Vitamin E is a group of eight compounds divided into two subgroups: four tocopherols (α-, β-, γ-, and δ-) and four tocotrienols (α-, β-, γ-, and δ-). α-Tocopherol is considered the most biologically active form. This review paper summarizes the current knowledge and historical progression of vitamin E research, with particular emphasis on its role in animal nutrition. Early studies in the 1920s identified vitamin E’s role in preventing neonatal mortality in rats. Over the following decades, scientists discovered the compound’s chemical structure and its importance for the immune system, skin health, anti-inflammatory properties, hormonal balance, and other bodily functions. Production of vitamin E products has evolved, starting with isolating the vitamin from natural sources and advancing to synthesizing it with greater efficiency and standardized potency units. Early animal studies focused on reproductive health and growth disorders, but further research demonstrated the importance of vitamin E in preventing encephalomalacia in domestic fowl and muscular dystrophy in rabbits and other animals. Today, vitamin E is commonly used as a feed additive to meet animals’ requirements and assure immune function and overall health. Despite much knowledge on vitamin E’s role in animal nutrition, many questions remain unanswered, and current research aims to determine optimal supplementation levels, interactions with other nutrients, impacts on gene expression, cell signaling and communication, and effects of supranutritional dosages in livestock. Vitamin E has a long and fascinating history in scientific research, with significant advancements in understanding its chemical structure and biological activity. In animal nutrition, vitamin E continues to play an important role in improving animal health, and ongoing research will continue to expand our understanding of its benefits and mechanisms of action.

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Vitamin E Supplementation Enhances Lipid Oxidative Stability via Increasing Vitamin E Retention, Rather Than Gene Expression of MAPK-Nrf2 Signaling Pathway in Muscles of Broilers

Cited by 4 publications

References 49 publications

A Century of Vitamin E: Early Milestones and Future Directions in Animal Nutrition

A Century of Vitamin E: Early Milestones and Future Directions in Animal Nutrition

Protective effects of dietary dimethyl itaconate supplementation on oxidative stress, inflammation, and apoptosis in broilers under chronic heat stress

A century of vitamin E: Early milestones and future directions in animal nutrition

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