Vitamin E Supplementation Decreases Lung Virus Titers in Mice Infected with Influenza

Hayek, Michael G.; Taylor, S F; Bender, Bradley S.; Han, Sung Nim; Meydani, Mohsen; Smith, Donald E.; Eghtesada, Shahriar; Meydani, Simin Nikbin

doi:10.1086/517265

Cited by 102 publications

(82 citation statements)

References 13 publications

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“…This possibility is supported by studies conducted in laboratory animals. Hayek et al (125) fed young and old mice either 30 or 500 parts per million (ppm) vitamin E for 8 weeks, at which time they were infected with influenza virus. Old mice fed 30 ppm of vitamin E had higher viral titres than young mice fed the same way.…”

Section: Vitamin Ementioning

confidence: 99%

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The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

Raman

Pal

Ganesan

et al. 2016

Eye

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Section: Vitamin Ementioning

confidence: 99%

“…Vitamin E supplementation (125,126) has also been shown to reduce lung viral titres following influenza infection. The evidence thus far suggests that improved immune response following nutrient intervention might have clinical significance for this age group.…”

Section: Multivitamin/mineral Supplementationmentioning

confidence: 99%

The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

Raman

Pal

Ganesan

et al. 2016

Eye

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“…In contrast, we observed significant myocarditis in adult mice infected with CVB3͞ 0 Old compared with mice infected with CVB3͞0 (P Ͻ 0.05) (Fig. 1C) (2). Heart pathology observed in adult mice infected with CVB3͞0 Old was comparable with myocarditis observed after infection with the virulent CVB3͞20 ( Fig.…”

Section: Cvb3͞0 Old Infection Was Associated With Weight Loss High Vmentioning

confidence: 55%

“…1D) (2). Adult CVB3͞ 0 Old -infected mice also tended to have greater liver pathology than adult CVB3͞0-infected mice (P ϭ 0.07) (Fig.…”

Section: Cvb3͞0 Old Infection Was Associated With Weight Loss High Vmentioning

confidence: 76%

“…Epidemiological, clinical, and animal data demonstrate that aged hosts frequently have a higher incidence, severity, and mortality from infections than adult hosts (1)(2)(3)(4)(5)(6). Current demographic data indicate that there are Ͼ400 million individuals worldwide over the age of 65 (7), and it is projected that the elderly population will double by 2020 and more than triple by 2050 (8).…”

mentioning

confidence: 99%

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An aged host promotes the evolution of avirulent coxsackievirus into a virulent strain

Gay

Belisle

Beck

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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The emergence of new, more pathogenic viruses necessitates elucidation of factors that promote viral evolution. Aging, a potential factor, is associated with increased susceptibility to viral infections. We used the enterovirus coxsackievirus B3 (CVB3) to investigate the effects of host age on pathogenicity and viral gene sequence. Old mice infected with a normally amyocarditic strain of CVB3, CVB3͞0, had significantly higher mean heart viral titers compared with CVB3͞0-infected adult mice. To determine whether a change in the CVB3͞0 viral population could contribute to the higher titers observed in the old infected mice, CVB3͞0 was passed once through an old or adult host and the changes in pathogenicity and viral genome were examined after subsequent infection of old or adult mice. Adult mice infected with CVB3͞0 that was passed through an old host (CVB3͞0 Old ) exhibited significantly higher heart viral titers, pathology, and weight loss than adult mice infected with either stock CVB3͞0 or CVB3͞0 passed through an adult host (CVB3͞0 Adult ). Sequence analysis of virus isolated from CVB3͞0 Old -infected mice revealed 13 specific and reproducible nucleotide changes. These changes result in a sequence that matches the virulent CVB3͞20 strain and are associated with promoting cardiovirulence. In contrast, we observed only one nucleotide change, low heart viral titers, and no heart and liver pathology in adult mice infected with CVB3͞0 Adult . These results demonstrate that the aged host promotes rapid selection of a pathogenic variant of CVB3 from an avirulent strain and introduces a host-virus paradigm for studies of viral infection in the aged.aging ͉ myocarditis ͉ oxidative stress ͉ pathology ͉ viral selection

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Vitamin E and Respiratory Tract Infections in Elderly Nursing Home Residents

Meydani¹,

Leka²,

Fine³

et al. 2004

JAMA

275

224

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NFECTIONS, PARTICULARLY RESPIRAtory tract infections, are common in elderly individuals, resulting in decreased daily activity, prolonged recovery times, increased health care service use, and more frequent complications, including death. [1][2][3][4][5][6][7][8][9][10][11] In the United States, an estimated 43% of elderly persons will be admitted to a nursing home, with more than 85% of them admitted to long-term (Ͼ1 year) care facilities. 12 Infections occur more frequently in nursing home residents than among independent-living elderly, 2-10,13 and respiratory tract infections are a major cause of morbidity and mortality. 9,14,15 Contributing to the increased incidence of infection with age is the well-described decline in immune response. 16 For example, those who have diminished delayed-type hypersensitivity skin test responses have higher morbidity and mortality from cancer, pneumonia, and postoperative complications. [17][18][19] Nutritional status is an important determinant of immune function. 20,21 Nutritional supplementation has been shown to enhance the immune response in older persons. 22,23 In our earlier pla-Author Affiliations are listed at the end of this article.

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Vitamin E Supplementation Decreases Lung Virus Titers in Mice Infected with Influenza

Cited by 102 publications

References 13 publications

The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

The prevalence and risk factors for age-related macular degeneration in rural–urban India, Sankara Nethralaya Rural–Urban Age-related Macular degeneration study, Report No. 1

An aged host promotes the evolution of avirulent coxsackievirus into a virulent strain

Vitamin E and Respiratory Tract Infections in Elderly Nursing Home Residents

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