Vitamin E supplementation and lifespan in model organisms

Ernst, Insa M. A.; Pallauf, Kathrin; Bendall, Jennifer K.; Paulsen, L.; Nikolai, Sibylle; Huebbe, Patricia; Roeder, Thomas; Rimbach, Gerald

doi:10.1016/j.arr.2012.10.002

Cited by 66 publications

(40 citation statements)

References 65 publications

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“…Supplementation of the growth medium with a-tocopherol increased oxidative stress while decreasing the cell lifespan in Saccharomyces cerevisiae (Lam et al 2010). Besides, there is no consistent beneficial effect of vitamin E on lifespan in model organisms consistent with reports in human intervention studies (Ernst et al 2013). Meta-analyses of randomized clinical trials of pharmacological dosage report negative or no effect on mortality/ lifespan (Abner et al 2011), no effects on cancer (Goodman et al 2011), but positive effects on prevention of cardiovascular disease Ye and Song 2008).…”

Section: Functions Of Plant Amino Acid-based Vitamins In Humansmentioning

confidence: 85%

Plant amino acid-derived vitamins: biosynthesis and function

Miret

Munné‐Bosch

2013

Amino Acids

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Vitamins are essential organic compounds for humans, having lost the ability to de novo synthesize them. Hence, they represent dietary requirements, which are covered by plants as the main dietary source of most vitamins (through food or livestock's feed). Most vitamins synthesized by plants present amino acids as precursors (B1, B2, B3, B5, B7, B9 and E) and are therefore linked to plant nitrogen metabolism. Amino acids play different roles in their biosynthesis and metabolism, either incorporated into the backbone of the vitamin or as amino, sulfur or one-carbon group donors. There is a high natural variation in vitamin contents in crops and its exploitation through breeding, metabolic engineering and agronomic practices can enhance their nutritional quality. While the underlying biochemical roles of vitamins as cosubstrates or cofactors are usually common for most eukaryotes, the impact of vitamins B and E in metabolism and physiology can be quite different on plants and animals. Here, we first aim at giving an overview of the biosynthesis of amino acid-derived vitamins in plants, with a particular focus on how this knowledge can be exploited to increase vitamin contents in crops. Second, we will focus on the functions of these vitamins in both plants and animals (and humans in particular), to unravel common and specific roles for vitamins in evolutionary distant organisms, in which these amino acid-derived vitamins play, however, an essential role.

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Section: Functions Of Plant Amino Acid-based Vitamins In Humansmentioning

confidence: 85%

Plant amino acid-derived vitamins: biosynthesis and function

Miret

Munné‐Bosch

2013

Amino Acids

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“…Meanwhile Vitamin E is the mutual name for a group of fat soluble compounds with distinctive antioxidant activities (Salama, 2013), it is found naturally in some foods, added to others, and available as a dietary complement. As a free radical scavenger and lipophilic molecule, vitamin E may protect the membranes from oxidative damage by reacting with fatty acid peroxides by electron transfer (Traber and Atkinson, 2007;Ernst et al, 2013), also, it may regulate gene expression (Azzi, 2007;Rimbach et al, 2010 ) The aim of this study was to evaluate the correlation between inhibin (as the indices of infertility) and some antioxidant in the blood of ALL patients.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Inhibin and Several Antioxidants in Children with Acute Lymphoblastic Leukemia

Mehde¹,

Mehdi²,

Zainulabdeen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Acute lymphoblastic leukemia (ALL) is most common in childhood. Inhibin (a non-steroidal glycoprotein hormone of gonadal origin) can be used as marker of fertility. The current study was conducted to evaluate inhibin levels in ALL patients and to estimate its correlation with some antioxidants in these in comparison with control subjects. Materials and Methods: This study was conducted on sixty patients with ALL and thirty children as controls. Fasting blood samples were taken from each subject and analyzed for haemoglobin, serum protein, vitamin E and C, in addition to glutathione and inhibin. Results: The results of the study showed highly significant decreases (p<0.001) in haemoglobin, glutathione and inhibin levels with significant decreases (p<0.05) in serum protein and vitamin E levels for patients group in comparison with controls while there was no significant differences in vitamin C. Moreover, there were significant correlations between inhibin levels and serum protein, glutathione and both vitamins (E and C) in the ALL patient group (r= 0.81, 0.80, 0.77 and 0.69, respectively). Conclusions: The present results indicated infertility in patients with ALL demonstrated by low inhibin level as a consequence of abnormality in anti-oxidative metabolism due to the cancer process. So, it can be suggested the need for routine measurement of inhibin for leukemic patients to estimate the action of hormones of gonadal origin.

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“…Unfortunately, this has turned out not to be the case as different studies yielded conflicting results, ranging from prolongation to a reduction of life span due to vitamin C or vitamin E treatment. Overall, it seems that there is no consistent beneficial effect of antioxidants on life span in model organisms [17,41].…”

Section: Physiological Role Of Stressmentioning

confidence: 94%

Stress and biological aging

Simm

Klotz

2015

Z Gerontol Geriat

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It is well accepted that aging is the basis of most degenerative diseases in the elderly. Biological aging is characterized by a gradual accumulation of cellular and molecular defects. An important cause of defects is intense stress, such as oxidative or glycotoxic stress. Genes affecting cellular and organismal longevity are frequently associated with the regulation of cellular anti-oxidative defense and/or with repair functions. Damage, combined with an age-dependent decline in defense and repair systems, results in disturbed homeostasis, leading to aging and diseases. Whereas intense stress induces premature aging, mild stress can induce adaptive processes, stimulating the expression of genetic repair/defense systems, which positively influences life span.

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Vitamin E supplementation and lifespan in model organisms

Cited by 66 publications

References 65 publications

Plant amino acid-derived vitamins: biosynthesis and function

Plant amino acid-derived vitamins: biosynthesis and function

Correlation of Inhibin and Several Antioxidants in Children with Acute Lymphoblastic Leukemia

Stress and biological aging

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