Vitamin E Serum Levels and the Challenge to Correct for Lipids: Accounting for the Usual Double Correction for Variance Shared by Total Cholesterol and Fasting Triglycerides Reveals New Insights into the Association with the One-Carbon Pathway

Minovíc, Isidor; Sotomayor, Camilo G.; Eggersdorfer, Manfred; Riphagen, Ineke J.; Borst, Martin H. de; Dekker, Louise H.; Navis, Gerjan; Nolte, Ilja M.; Zon, Sander K R van; Reijneveld, Sijmen A.; Molen, J.C. van der; Jong, Wilhelmina H. A. de; Kootstra‐Ros, Jenny E.; Kema, Ido P.; Bakker, Stephan J. L.

doi:10.1007/978-3-030-05315-4_15

Cited by 1 publication

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Section: Serum Vitamin E Levels Serum Lipid Levels and Adjustment Of ...mentioning

confidence: 99%

“…As vitamin E is carried by lipoproteins in circulation, serum vitamin E levels are positively affected by serum lipid levels [49]. A proper correction for this effect is required to accurately assess an individual's vitamin E status [49]. In the present study, we controlled for this effect by calculating vitamin E/total lipid ratio; this has been suggested to be the most reliable estimate for evaluating vitamin E status in adults [50,51].…”

Section: Serum Vitamin E Levels Serum Lipid Levels and Adjustment Of ...mentioning

confidence: 99%

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Age and Sex Differences in the Association between Serum Vitamin E Levels and Depressive Symptoms: Korea National Health and Nutrition Examination Survey

Jeong¹,

Son

et al. 2023

Nutrients

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Studies have reported inconsistent results regarding the relationship between serum vitamin E levels and depressive symptoms. Furthermore, the potential modulating role of age and sex has been underexplored. We conduct an age- and sex-stratified investigation of the association between serological vitamin E status and depressive symptoms in a large nationwide sample. Data from the Korean National Health and Nutrition Examination Survey were analyzed (n = 4448). The participants were stratified into four groups according to age (<65 vs. ≥65 years) and sex. Each group was divided into tertiles of vitamin E/total lipid ratio, and Patient Health Questionnaire-9 (PHQ-9) scores were compared among the tertiles via multivariable linear regression analyses. The relationship between dietary supplement use and the proportions of tertiles was assessed in each group. With the middle tertile as the reference group, the low tertile of vitamin E/total lipid ratio was associated with increased PHQ-9 scores in younger females and older males after adjusting for all covariates, while the high tertile showed no significant associations with PHQ-9 scores in any group. The low tertile was associated with increased adjusted mean PHQ-9 scores by 0.53 and 1.02 compared to the middle tertile in younger females and older males, respectively. Dietary supplement use was related to higher vitamin E/total lipid ratio in all four groups. In conclusion, younger females and older males with a low vitamin E status showed worse depressive symptoms. These individuals may benefit from dietary interventions to prevent depressive symptoms.

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Section: Serum Vitamin E Levels Serum Lipid Levels and Adjustment Of ...mentioning

confidence: 99%

Section: Serum Vitamin E Levels Serum Lipid Levels and Adjustment Of ...mentioning

confidence: 99%

Age and Sex Differences in the Association between Serum Vitamin E Levels and Depressive Symptoms: Korea National Health and Nutrition Examination Survey

Jeong¹,

Son

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

Vitamin E Serum Levels and the Challenge to Correct for Lipids: Accounting for the Usual Double Correction for Variance Shared by Total Cholesterol and Fasting Triglycerides Reveals New Insights into the Association with the One-Carbon Pathway

Cited by 1 publication

References 34 publications

Age and Sex Differences in the Association between Serum Vitamin E Levels and Depressive Symptoms: Korea National Health and Nutrition Examination Survey

Age and Sex Differences in the Association between Serum Vitamin E Levels and Depressive Symptoms: Korea National Health and Nutrition Examination Survey

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