Vitamin E requirements, transport, and metabolism: Role of α-tocopherol-binding proteins

Duttaroy, Asim K.; Gordon, Margaret Jane; Campbell, Fiona; Duthie, Garry G.; James, W. P. T.

doi:10.1016/0955-2863(94)90010-8

Cited by 74 publications

(40 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(19,20). The other forms of vitamin E are similarly absorbed and reach the liver in chylomicron remnants, being excreted into the bile with excess of = -tocopherol (20,21).…”

Section: Resultsmentioning

confidence: 99%

“…(19,20). The other forms of vitamin E are similarly absorbed and reach the liver in chylomicron remnants, being excreted into the bile with excess of = -tocopherol (20,21). There is a quantitative limitation in tocopherol-binding protein incorporation of = -tocopherol in VLDL that could be explained by the inability to raise plasma terol in the = -tocopherol group was due to an alteration in cholesterol catabolism.…”

Section: Resultsmentioning

confidence: 99%

“…Free access to food and water was provided. The basic composition (g/100 g) of the atherogenic diet was: sucrose (50.2), casein (20), lard (15), salt mixture (5), cellulose (5), vitamin mixture (1), soybean oil (1), choline (1), cholesterol (1), cholic acid (0.5), and methionine (0.3).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

See 2 more Smart Citations

Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

Peluzio

Homem

César

et al. 2001

Braz J Med Biol Res

View full text Add to dashboard Cite

Although the role of oxidized lipoproteins is well known in atherogenesis, the role of vitamin E supplementation is still controversial. There is also little information about cholesterol metabolism (hepatic concentration and fecal excretion) in the new models of atherosclerosis. In the present study, we evaluated the effect of moderate vitamin E supplementation on cholesterol metabolism and atherogenesis in apolipoprotein E (apo E)-deficient mice. Apo E-deficient mice were fed an atherogenic diet containing 40 or 400 mg/kg of = -tocopherol acetate for 6 weeks. Total cholesterol in serum and liver and 3-OH-=-sterols in feces, and fecal excretion of bile acids were determined and histological analyses of aortic lesion were performed. A vitamin Erich diet did not affect body weight, food intake or serum cholesterol. Serum and hepatic concentrations of cholesterol as well as sterol concentration in feces were similar in both groups. However, when compared to controls, the = -tocopherol-treated mice showed a reduction of about 60% in the atherosclerotic lesions when both the sum of lesion areas and the average of the largest lesion area were considered. These results demonstrate that supplementation of moderate doses of = -tocopherol was able to slow atherogenesis in apo E-deficient mice and to reduce atherogenic lipoproteins without modifying the hepatic pool or fecal excretion of cholesterol and bile acids.

show abstract

“…(19,20). The other forms of vitamin E are similarly absorbed and reach the liver in chylomicron remnants, being excreted into the bile with excess of = -tocopherol (20,21).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

Peluzio

Homem

César

et al. 2001

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…After absorption (Cohn, 1993) vitamin E is transported by chylomicrons and tocopherol-binding proteins to the liver (Dutta-Roy et al, 1994;Arita et al, 1995), stored and later transported to the fat and muscles. Liver and serum therefore showed the most important increase in the content of this vitamin after short-term its supplementation (Table 3).…”

Section: Resultsmentioning

confidence: 99%

Influence of short-term vitamin E supplementation to bulls fed different concentrates on vitamin E content in body tissues and oxidative stability of kidney fat

Flachowsky¹,

Kuhn²,

Schneider³

et al. 1997

J. Anim. Feed Sci.

View full text Add to dashboard Cite

Two groups of 14 fattening bulls each were individually fed from 177 to 552 kg body weight with wilted grass silage ad libitum and concentrate based on maize (maize group) or wheat (wheat group), 2.7 kg per animal and day. Twenty one days before slaughter the diet of seven bulls of each group was supplemented with 1 g a-tocopherylacetate per animal and day. During slaughter, samples of blood, liver, M. longissimus dorsi and kidney fat were taken for vitamin E determination by HPLC. Fatty acid pattern and induction time of kidney fat were determined by the Rancimat test.Diet did not influence silage dry matter intake (5.55 and 5.58 kg) and daily weight gain of bulls (1197 and 1203 g for maize and wheat group, respectively).Vitamin E supply increased its content in serum (1.36/1.52 and 1.48/1.88 /ig/ml), liver (9.6/13.7 and 10.1/11.8) and fat (8.3/10.3 and 9.0/9.3), but it did not influence its content in muscle (0.92/1.14 and 1.16/1.11 ^g/g) in maize or wheat group, without/with vitamin E supplementation. The induction time of kidney fat increased as the vitamin E content of fat rose (from 3.82 to 5.39 h).Kind of ration and vitamin E supplementation did not significantly influence the fatty acid proportion of kidney and intramuscular fat, pH, drip loss and and colour of meat.Short term-vitamin E supplementation of diets for bulls may influence vitamin E content in body tissues, but longer application seems to be necessary for more pronounced effects.KEY WORDS: fattening bulls, vitamin E, meat quality, oxidative stability, fatty acids pattern 440 FLACHOWSKY G. ET AL.

show abstract

“…The increase in backfat was not so dramatic, it was mostly not significant in muscle (Table 2). Vitamin E is transported by tocopherol-binding proteins to the liver (Cohn, 1993;Dutta-Roy et al, 1994;Arita et al, 1995). It is stored in the liver and later deposited in fat and muscles.…”

Section: Methodsmentioning

confidence: 99%

Vitamin E-Transfer from Feed into Pig Tissues

Flachowsky¹

2000

Journal of Applied Animal Research

View full text Add to dashboard Cite

show abstract

Vitamin E requirements, transport, and metabolism: Role of α-tocopherol-binding proteins

Cited by 74 publications

References 67 publications

Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

Influence of short-term vitamin E supplementation to bulls fed different concentrates on vitamin E content in body tissues and oxidative stability of kidney fat

Vitamin E-Transfer from Feed into Pig Tissues

Contact Info

Product

Resources

About