Vitamin E regulates mitochondrial hydrogen peroxide generation

Chow, Ching K.; Ibrahim, Wissam H.; Wei, Zhengyu; Chan, Alvin C.

doi:10.1016/s0891-5849(99)00121-5

Cited by 154 publications

(76 citation statements)

References 65 publications

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“…H 2 O 2 may accumulate, which would lead to a condition of mitochondial oxidative stress (Kowaltowski and Vercesi, 1999). Vitamin E can directly regulate H 2 O 2 production (Chow et al, 1999). In our study, vitamin E supplementation restored fatty acid distribution near the control group.…”

Section: Resultssupporting

confidence: 47%

“…A significant reduction in PUFA in the hydrogen peroxide group that was observed in the present investigation supports the previous work. Chow et al (1999) reported that vitamin E can directly regulate hydrogen peroxide production in mitochondria, and suggested that the overproduction of mitochondrial ROS is the first event that leads to tissue damage that is observed in Vitamin E-deficiency syndromes. H 2 O 2 may accumulate, which would lead to a condition of mitochondial oxidative stress (Kowaltowski and Vercesi, 1999).…”

Section: Resultsmentioning

confidence: 99%

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Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂

Çelik¹,

Özkaya²

2002

BMB Reports

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The aim of our study was to investigate the protective effects of intraperitoneally-administrated vitamin E, dlalpha lipoic acid, and linalool on the level of total lipid and fatty acid in guinea pig brains with oxidative stress that was +vitamin E groups. While the proportion of the total w3 (omega 3), w6 (omega 6), and PUFA were found to be lowest in the H 2 O 2 group, they were slightly increased (p<0.05) in the lipoic acid group when compared to the control and H 2 O 2 + lipoic acid groups. However, the level of ΣSFA in the H 2 O 2 group was highest; the level of ΣUSFA in same group was lowest. As the proportion of ΣUSFA and ΣPUFA were found to be highest in the linalool group, they were decreased in the H 2 O 2 group when compared to the control group. Our results show that linalool has antioxidant properties, much the same as vitamin E and lipoic acid, to prevent lipid peroxidation. Additionally, vitamin E, lipoic acid, and linalool could lead to therapeutic approaches for limiting damage from oxidation reaction in unsaturated fatty acids, as well as for complementing existing therapy for the treatment of complications of oxidative damage.

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Section: Resultssupporting

confidence: 47%

Section: Resultsmentioning

confidence: 99%

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂

Çelik¹,

Özkaya²

2002

BMB Reports

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“…It is generally accepted that the electron-transport chain in the mitochondria is responsible for major part of superoxide production in the body [6]. Mitochondrial electron transport system consumes more than 85% of all oxygen used by the cell and, because the efficiency of electron transport is not 100%, about 1-3% of electrons escape from the chain and the univa lent reduction of molecular oxygen results in superoxide anion formation [13][14][15]. About 10 12 O 2 molecules processed by each rat cell daily and if the leakage of partially reduced oxygen molecules is about 2%, this will yield about 2 x 10 10 molecules of ROS per cell per day [16].…”

Section: Free Radicals and Reactive Oxygen And Nitrogen Speciesmentioning

confidence: 99%

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Surai¹

2016

J Anim Res Nutr

160

135

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Commercial poultry production is associated with various stresses responsible for decreasing productive and reproductive performance of growing chicks, breeders and commercial layers. A growing body of evidence shows that most of stresses in poultry production at the cellular level are associated with oxidative stress. Recently, a concept of the cellular antioxidant defense has been revised with special attention paid to cellular redox status maintenance and cell signaling. In fact, antioxidant systems of the living cell are based on three major levels of defense and superoxide dismutase (SOD) is shown to belong to the first level of the antioxidant defense network. Cellular antioxidant defenses are shown to include several options and vitagene activation in stress conditions is considered as a fundamental adaptive mechanism. The vitagene family includes various genes regulating synthesis of protective molecules including thioredoxins, sirtuins, heat shock proteins and SOD. However, by the time of writing no comprehensive review on the roles and effects of SOD in poultry biology has appeared. Therefore, the aim of this review is a critical analysis of the role of SOD in poultry biology with specific emphasis to its functions as an essential part of the vitagene network. From the analysis of the recent data related to SOD in poultry physiology and adaptation to stresses it is possible to conclude that: a) SOD as important vitagene is the main driving force in cell/body adaptation to various stress conditions. Indeed, in stress conditions additional synthesis of SOD is an adaptive mechanism to decrease ROS formation; b) If the stress is too high SOD activity is decreased and apoptosis is activated; c) there are tissue-specific differences in SOD expression which also depends on the strength of such stress-factors as heat, heavy metals, mycotoxins and other stressors; d) SOD is shown to provide an effective protection against lipid peroxidation in chicken embryonic tissues and semen; e) SOD is shown to be protective in heat and cold stress, toxicity stress as well as in other oxidative-stress related conditions in poultry production; f) there are complex interactions inside the antioxidant network of the cell/body to ensure an effective maintenance of homeostasis in stress conditions. Indeed, in many cases, nutritional antioxidants (vitamin E, selenium, carotenoids, phytochemicals, etc.) in the feed can increase SOD expression; g) nutritional means of SOD upregulation in stress conditions of poultry production and physiological and commercial consequences await further investigation; h) vitagene upregulation in stress conditions is emerging as an effective means for stress management.

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“…A decrease in the antioxidant vitamin level may also result from the intensification of the secondary stages of lipid peroxidation. Chow et al (1999) demonstrated that a decrease in the content of vitamin E leads to a marked increase in the production of H 2 O 2 in both the mitochondria of skeletal muscles and the mitochondria of the liver.…”

Section: Group Of Animalsmentioning

confidence: 99%

Concentration of hepatic vitamins A and E in rats exposed to chlorpyrifos and/or enrofloxacin

Spodniewska¹,

Barski²

2016

Polish Journal of Veterinary Sciences

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The aim of the study was to determine the level of antioxidant vitamins A and E in the liver of rats exposed to chlorpyrifos and/or enrofloxacin. Chlorpyrifos (Group I) was administered at a dose of 0.04 LD 50 (6 mg/kg b.w.) for 28 days, and enrofloxacin (Group II) at a dose of 5 mg/kg b.w. for 5 consecutive days. The animals of group III were given both of the mentioned above compounds at the same manner as groups I and II, but enrofloxacin was applied to rats for the last 5 days of chlorpyrifos exposure (i.e. on day 24, 25, 26, 27 and 28). Chlorpyrifos and enrofloxacin were administered to rats intragastrically via a gastric tube. The quantitative determination of vitamins was made by the HPLC method. The results of this study indicated a reduction in the hepatic concentrations of vitamins A and E, compared to the control, which sustained for the entire period of the experiment. The four-week administration of chlorpyrifos to rats resulted in a significant decrease of vitamins in the initial period of the experiment, i.e. up to 24 hours after exposure. For vitamin A the maximum drop was observed after 24 hours (19.24%) and for vitamin E after 6 hours (23.19%). Enrofloxacin caused a slight (3-9%) reduction in the level of the analysed vitamins. In the chlorpyrifos-enrofloxacin co-exposure group reduced vitamins A and E levels were also noted, but changes in this group were less pronounced in comparison to the animals intoxicated with chlorpyrifos only. The decrease in the antioxidant vitamin levels, particularly noticeable in the chlorpyrifos-and the chlorpyrifos combined with enrofloxacin-treated groups, may result not only from the increase in the concentration of free radicals, but also from the intensification of the secondary stages of lipid peroxidation.

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Vitamin E regulates mitochondrial hydrogen peroxide generation

Cited by 154 publications

References 65 publications

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Concentration of hepatic vitamins A and E in rats exposed to chlorpyrifos and/or enrofloxacin

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Vitamin E regulates mitochondrial hydrogen peroxide generation

Cited by 154 publications

References 65 publications

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H2O2

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H2O2

Antioxidant Systems in Poultry Biology: Superoxide Dismutase

Concentration of hepatic vitamins A and E in rats exposed to chlorpyrifos and/or enrofloxacin

Contact Info

Product

Resources

About

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂