Vitamin E protects salivary glands dysfunction induced by ionizing radiation in rats

Abedi, Seyed Mohammad; Yarmand, Fateme; Mina, Mani; Seyedmajidi, Maryam; Moslemi, Dariush; Ashrafpour, Manouchehr; Bijani, Ali; Moghadamnia, Ali Akbar; Mardanshahi, Alireza; Hosseinimehr, Seyed Jalal

doi:10.1016/j.archoralbio.2015.06.003

Cited by 20 publications

(16 citation statements)

References 58 publications

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“…Protection against radiation-induced damage in small bowel crypts of rats [45] , modification of micronucleus induction by g rays in mice [46] , and invitro reduction in the number of micronuclei in human lymphocytes before and after gamma-ray irradiation have also been reported by others [15] . The same results were found in salivary gland [47] . On the other hand, some authors found no changes resulted in pre-irradiation treatment with vitamin E [48] .…”

Section: Discussionsupporting

confidence: 86%

The possible radioprotective effects of vitamin E, Nigella sativa oil, and melatonin against X-ray induced early acute changes in cerebral and cerebellar cortices in Albino rats: Histological and Immunohistochemical study.

Nor-Eldin

Elsayed

2019

Egyptian Journal of Histology

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Background: Radiation induced brain and cerebellum injury is common in patients receiving radiotherapy for head and neck tumors. Administration of antioxidants before radiation as vitamin E, nigella sativa oil and melatonin could be valuable in limiting this injury. Material and Methods: 40 rats were divided into five different groups. Group Ι: served as the control group and subdivided into 4subgroups. subroup Ia: negative control, subgroup Ib: animals received vitamin E only (300 mg/kg orally once, subgroup Ic: animals received nigella sativa oil only (1ml/kg orally once and subgroup Id: animals received melatonin only 100 mg/ kg intraperitoneally once: Group ΙΙ: animals were exposed to x ray irradiation (XRI) (8 Gy whole body). Group ΙΙΙ: animals were pretreated with vitamin E (300 mg/kg orally once 1h before XRI. Group ΙV: animals were pretreated with nigella sativa oil(1ml/kg orally once1h before XRI). Group V: animals were pretreated with melatonin (100 mg/kg intraperitoneally once 1h before XRI). Animals were sacrificed 48h after irradiation. Brain and cerebellum were dissected, formalin fixed and processed for histological and glial fibrillary acidic protein (GFAP) immunostainig. The number of GFAP positive astrocytes were counted and statistically analyzed using SPSS program. Results: Radiation induced loss of lamellar pattern in the cerebral cortex with degeneration and necrosis of cortical nerve cells. In the cerebellum, purkinje cell degeneration was observed. Radiation induced a significant increase in the number of GFAP positive astrocytes in both cerebral and cererbellar cortices compared to the control group. In groups treated with vitamin E, nigella sativa oil and melatonin, there was partial improvement in cerebral and cerebellar changes with a significant decrease in the number of GFAP positive astrocytes. Conclusion: The use of antioxidants such as vitamin E, nigella and melatonin could limit radiation induced injury in brain and cerebellum.

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Section: Discussionsupporting

confidence: 86%

The possible radioprotective effects of vitamin E, Nigella sativa oil, and melatonin against X-ray induced early acute changes in cerebral and cerebellar cortices in Albino rats: Histological and Immunohistochemical study.

Nor-Eldin

Elsayed

2019

Egyptian Journal of Histology

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“…Alpha-Tocopherol was used previously in a dose of 360mg/kg rat body weight 22 i.e 54 mg/150g rat body weight which was applied in the current study. Turmeric was used as 1100 mg/kg rat body weight according to Rajashekhara et al 23 i.e 165 mg/ 150 g rat body weight.…”

Section: Preparation Of Different Nutraceuticalsmentioning

confidence: 99%

Role of Borage Seed Oil and Fish Oil with or without Turmeric and Alpha- Tocopherol in Prevention of Cardiovascular Disease and Fatty Liver in Rats

et al. 2018

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Introduction Cardiovascular diseases CVDs are considered as the major cause of morbidity and death worldwide in both developed and developing countries 1. Dyslipidemia, oxidative stress and inflammation are among the reported risk factors for cardiovascular diseases 2. Recently fatty liver with inflammation steatohepatitis , which is increasing worldwide, is accused as being major player in induction of cardiovascular diseases 3. Generally, the condition including dyslipidemia, inflammation, steatohepatitis, oxidative stress and impaired glucose tolerance is called metabolic syndrome.

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“…Moreover, it markedly inhibited the production of TNF- α and IL-6 in lipopolysaccharide-stimulated inflammatory response in mouse mammary epithelial cells [29]. Recently, Abedi et al reported that thymol significantly protected against acute and chronic salivary gland dysfunction induced by ionizing radiation in the rats [30]. Despite these mentioned studies, no reports explored the potential protective effects of these essential oils against radiotherapy-induced ovarian failure or linked their radioprotection in ovaries with the serum IGF-1 levels.…”

Section: Introductionmentioning

confidence: 99%

Carvacrol and Thymol Modulate the Cross-Talk between TNF-α and IGF-1 Signaling in Radiotherapy-Induced Ovarian Failure

Mahran

Badr

Aldosari

et al. 2019

Oxidative Medicine and Cellular Longevity

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Premature ovarian failure (POF) is a common cause of infertility in premenopausal women who are unavoidably exposed to cytotoxic therapy. Radiotherapy is one of the most effective cytotoxic treatments. However, the radiosensitivity of ovarian tissues limits its therapeutic outcome and results in the depletion of the primordial follicle and loss of fertility. Therefore, the need for an effective radioprotective therapy is evident especially when none of the current clinically used modalities for radioprotection succeeds efficiently. The present study investigated the potential radioprotective effect of carvacrol (CAR) (80 mg) or thymol (80 mg) on gamma- (γ-) irradiation-induced ovarian damage as well as their role in the cross-talk between IGF-1 and TNF-α signaling and antioxidative activity. In immature female Wister rats, a single dose of whole-body irradiation (3.2 Gy, LD20) produced considerable ovarian damage, which was evident by histopathological findings and hormonal changes. Interestingly, pretreatment with CAR or thymol significantly enhanced the follicular development and restored the anti-Mullerian hormone (AMH), E2, and FSH levels. Both essential oils improved the irradiation-mediated oxidative stress and reduction in proliferating cell nuclear antigen (PCNA) expression. Moreover, irradiated rats exhibited an inverse relationship between IGF-1 and TNF-α levels two days post irradiation, which was further inverted by the pretreatment with CAR and thymol and ought to contribute in their radioprotective mechanisms. In conclusion, CAR and thymol showed a radioprotective effect and rescued the ovarian reserve mainly through counteracting oxidative stress and the dysregulated cross-talk between IGF-1 and TNF-α.

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Vitamin E protects salivary glands dysfunction induced by ionizing radiation in rats

Cited by 20 publications

References 58 publications

The possible radioprotective effects of vitamin E, Nigella sativa oil, and melatonin against X-ray induced early acute changes in cerebral and cerebellar cortices in Albino rats: Histological and Immunohistochemical study.

The possible radioprotective effects of vitamin E, Nigella sativa oil, and melatonin against X-ray induced early acute changes in cerebral and cerebellar cortices in Albino rats: Histological and Immunohistochemical study.

Role of Borage Seed Oil and Fish Oil with or without Turmeric and Alpha- Tocopherol in Prevention of Cardiovascular Disease and Fatty Liver in Rats

Carvacrol and Thymol Modulate the Cross-Talk between TNF-α and IGF-1 Signaling in Radiotherapy-Induced Ovarian Failure

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