Vitamin E Protects against Metasystox‐induced Adverse Effect on Lipid Metabolism in the Rat Brain and Spinal Cord

Abstract

The effects of vitamin E (alpha-tocopherol) on the rate of lipid peroxidation and lipase activity in the discrete areas of the brain and spinal cord were studied. Administration of metasystox in two different doses 1.0 and 2.0 mg/kg body weight intraperitoneally daily for 10 days have shown a dose-related depletion of total lipids, cholesterol and esterified fatty acids in the rat cerebral hemisphere, cerebellum, brain stem and spinal cord. The rate of lipid peroxidation and lipase activity showed dose-dependent increase in different regions of the CNS. Administration of alpha-tocopherol alone caused significant reduction of lipid peroxidation and lipase activity. When it was administered simultaneously with metasystox, alpha-tocopherol prevented the metasystox-induced increase of lipid peroxidation and lipase activity.

Regional Distribution of Imipramine, Desipramine and Specific [3H]Desipramine Binding Sites in the Rat Brain after Acute and Chronic Treatment with Imipramine

“…If the distribution of the drugs is caused just by lipophilicity, their accumulation in particular regions of the rat CNS should be proportional to the lipid level in those areas. However, their distribution did not follow the quantitative and qualitative lipid content in particular brain regions (Tayyaba & Hasan 1985) in the slow-disposition phase (a relatively high level of both drugs in the cortex in comparison with the brain stem or hippocampi).…”

“…In the elimination phase under steady-state conditions relatively high levels of the drugs were found in the hippocampi, striatum, limbic forebrain and brain stem, i.e. in the areas that contain more lipids than the cortex (Tayyaba & Hasan 1985). This finding might indicate that in the elimination phase under steady-state conditions the lipid content in the region and lipophilicity of the substances are crucial factors which determine the drugs' regional cerebral distribution.…”

Redistribution of Imipramine from Regions of the Brain Under the Influence of Circulating Specific Antibodies

“…Nevertheless, the accumulation of IMI in some brain regions did not parallel the lipid levels. The concentrations of IMI were high in the frontal cortex, hippocampus, and thalamus, areas that contain less lipid than the ponsmedulla (Tayyaba and Hasan, 1985). IMI, like other cationic amphiphilic drugs, was also accumulated within the cells as a result of lysosomotropism (De Duve et al, 1974).…”

Effects of two isomeric 1-aminoadamantanes on the membrane anisotropy and on alpha- and gamma-motoneurones excitability

“…The available data indicate that the brain stem and the spinal cord are the regions containing more lipids and relatively more cholesterol than other areas investigated (Tayyaba and Hasan, 1985). As both, D 174 and D 175, are hydrophobic compounds (Henkel and Hane, 1982) their accumulation in particular regions of the CNS should be proportional to the lipid level in these areas, if the distribution would be caused just by lipophilicity.…”