Vitamin E: Interactions with Free Radicals and Ascorbate

McCay, Paul B.

doi:10.1146/annurev.nu.05.070185.001543

Cited by 498 publications

(116 citation statements)

References 36 publications

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“…Intracellularly, vitamin E is associated with the lipid-rich membranes those of mitochondria and microsomes. It protects LPO most efficiently through its chainbreaking antioxidant action (McCay, 1985;Maydani, 1995). Apart from the antioxidant action vitamin E also has membrane-stabilizing effects (Van Acker et al, 1993, Flohe & Traber, 1999.…”

Section: Discussionmentioning

confidence: 99%

Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients

et al. 2005

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Background: A constellation of reactive oxygen species (ROS) capable of damaging cellular constituents generated in excess during the chronic, inflammatory, neurodegenerative disease process of leprosy. The consequences of this leads to enhanced oxidative stress and lower antioxidant status. Enzymatic antioxidants provide first line defense against ROS. We have measured the levels of oxidative stress indices like lipid peroxidation (LPO), protein carbonyls together with enzymatic antioxidants in the blood samples of control and leprosy patients. Nutritional rehabilitation by way of exogenous supplementation of functionally efficient antioxidants like vitamin E reactivates the enzymatic antioxidant system and guards against the insult caused by ROS during the pathogenesis of the disease and antileprosy chemotherapy. Design: Untreated leprosy patients were selected on the basis of clinical examination and skin smear. All diagnosed untreated leprosy patients received multi drug therapy (MDT) consisting of rifampicin, dapsone and clofazimine as recommended by World Health Organization. A small number of untreated cases were selected for co-supplementation of vitamin E along with MDT. Oxidative stress indices, enzymatic and nonenzymatic antioxidant status were assayed in untreated, MDT treated and those supplemented vitamin E along with MDT. Statistical methods: We have compared the significance in the mean7s.d. values of the oxidative stress indices and the levels of antioxidants using one way analysis of variance (ANOVA) between control, untreated, MDT treated and those supplemented vitamin E with MDT and the results were significant at Po0.05. Statistical analysis of the results suggests that oral administration of vitamin E lowers oxidative stress and augments antioxidant status in affected individuals. Results: Enhanced oxidative stress as evidenced by increased LPO and protein carbonyl in leprosy cases lowers the antioxidant status. Treatment with MDT has a limited impact on increased oxidative stress and decreased antioxidant status. Coadministration of vitamin E along with MDT decreases oxidative stress and activate the antioxidant status. Discussion: The excess production of ROS as seen in leprosy cases could lead to degeneration of tissues and derangement of internal organs. The possible reason for the decreased antioxidant status in leprosy cases may be increased production of ROS, deranged liver function, and the free radical producing ability of drugs used in MDT of leprosy. Intervention with antioxidant supplementation like vitamin E prevents oxidative stress mediated through ROS and activates the net antioxidant status during the chronic course of the disease and antileprosy chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients

et al. 2005

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“…Therefore, the maintenance of ascorbate level in the RTLF requires transportation from cellular sources or from the plasma pool [59]. Ascorbate also acts indirectly to prevent lipid peroxidation [59] and contributes to the regeneration of membrane-bound oxidised vitamin E [63]. Ascorbate plays a role in immune function and is transported into neutrophils and lymphocytes [18].…”

Section: Antioxidant Nutrientsmentioning

confidence: 99%

Air pollution, oxidative stress and dietary supplementation: a review

Romieu

Castro-Giner²,

Künzli³

et al. 2008

European Respiratory Journal

219

157

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The aim of the present review was to provide an up-to-date overview of the biological and epidemiological evidence of the role of oxidative stress as a major underlying feature of the toxic effect of air pollutants, and the potential role of dietary supplementation in enhancing antioxidant defences.A bibliographic search was conducted through PubMed. The keywords used in the search were ''air pollutant'', ''oxidative stress'', ''inflammation'', ''antioxidant polyunsaturated fatty acids'' and ''genetics''. In addition, the authors also searched for biomarkers of oxidative stress and nutrients.The review presents the most recent data on: the biological and epidemiological evidence of the oxidative stress response to air pollutants; the role of dietary supplementation as a modulator of these effects; and factors of inter-individual variation in human response. The methodology for further epidemiological studies will be discussed in order to improve the current understanding on how nutritional factors may act.There is substantial evidence that air pollution exposure results in increased oxidative stress and that dietary supplementation may play a modulating role on the acute effect of air pollutants. Further epidemiological studies should address the impact of supplementation strategies in the prevention of air-pollution-related long-term effects in areas where people are destined to be exposed for the distant future.

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“…Vitamin E is the name given to a number of structurally-related compounds, the most important of which is alpha-tocopherol. Vitamin E is needed for the mitochondria electron transport function and prevents oxidation of various compounds, including unsaturated fatty acids (McCay, 1985). Vitamin E is important in biological systems.…”

Section: Introductionmentioning

confidence: 99%

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂

Çelik¹,

Özkaya²

2002

BMB Reports

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The aim of our study was to investigate the protective effects of intraperitoneally-administrated vitamin E, dlalpha lipoic acid, and linalool on the level of total lipid and fatty acid in guinea pig brains with oxidative stress that was +vitamin E groups. While the proportion of the total w3 (omega 3), w6 (omega 6), and PUFA were found to be lowest in the H 2 O 2 group, they were slightly increased (p<0.05) in the lipoic acid group when compared to the control and H 2 O 2 + lipoic acid groups. However, the level of ΣSFA in the H 2 O 2 group was highest; the level of ΣUSFA in same group was lowest. As the proportion of ΣUSFA and ΣPUFA were found to be highest in the linalool group, they were decreased in the H 2 O 2 group when compared to the control group. Our results show that linalool has antioxidant properties, much the same as vitamin E and lipoic acid, to prevent lipid peroxidation. Additionally, vitamin E, lipoic acid, and linalool could lead to therapeutic approaches for limiting damage from oxidation reaction in unsaturated fatty acids, as well as for complementing existing therapy for the treatment of complications of oxidative damage.

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Vitamin E: Interactions with Free Radicals and Ascorbate

Cited by 498 publications

References 36 publications

Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients

Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients

Air pollution, oxidative stress and dietary supplementation: a review

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂

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Vitamin E: Interactions with Free Radicals and Ascorbate

Cited by 498 publications

References 36 publications

Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients

Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients

Air pollution, oxidative stress and dietary supplementation: a review

Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H2O2

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Effects of Intraperitoneally Administered Lipoic Acid, Vitamin E, and Linalool on the Level of Total Lipid and Fatty Acids in Guinea Pig Brain with Oxidative Stress Induced by H₂O₂