Vitamin E Intake Affects Serum Thromboxane and Tissue Essential Fatty Acid Composition in the Rat

Cunnane, Stephen C.

doi:10.1159/000177413

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…However, there was no significant effect of a-tocopherol and Se on plasma 6-keto-prostaglandin F,, concentrations (Table 4). In contrast, the plasma concentration of thromboxane B, increased significantly, in agreement with the findings reported by Cunnane (1988). The difference in response may be as a result of the reported inhibition of prostacyclin synthase by lipid hydroperoxides (Valentovic et al 1982).…”

Section: Discussionsupporting

confidence: 89%

Lipid peroxidation, prostacyclin and thromboxane A₂in pigs depleted of vitamin E and selenium and supplemented with linseed oil

Nolan¹,

Kennedy²,

Blanchflower³

et al. 1995

Br J Nutr

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In a 2 x 2 balanced factorial experiment the biochemical effects on pigs of two dietary factors were investigated. The first factor was a-tocopherol and Se supplementation and the second factor was supplementation with a-tocopherol-stripped linseed oil. In pigs fed on diets depleted of a-tocopherol and Se, increases in concentrations of markers of Lipid peroxidation (4hydroxynonenal and hexanal) were observed. However, skeletal myopathy was only observed in those pigs fed on diets depleted of atocopherol and Se and supplemented with oil. In those pigs, increased lipid peroxidation was observed in heart and supraspinatus muscle. The plasma concentration of thromboxane B, was increased in pigs fed on diets depleted of a-tocopherol and Se, suggesting an increased tendency towards platelet aggregation. However, this change was reversed in pigs depleted of a-tocopherol and Se, but supplemented with oil. This may have been a consequence of loss of arachidonic acid, the substrate for thromboxane formation, as a result of Lipid peroxidation.

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Section: Discussionsupporting

confidence: 89%

Lipid peroxidation, prostacyclin and thromboxane A₂in pigs depleted of vitamin E and selenium and supplemented with linseed oil

Nolan¹,

Kennedy²,

Blanchflower³

et al. 1995

Br J Nutr

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“…According to our results 20:4n-6 was influenced by vitamin E, but only in liver. A rise of 20:4n-6 due to vitamin E deficiency has also been observed by others (Witting, 1969;h a t , 1983;Cunnane, 1988). This effect has been ascribed to the lack of inhibition of desaturases by a-tocopherol.…”

Section: Discussionsupporting

confidence: 57%

Phospholipid fatty acids of brain and liver are modified by α-tocopherol and dietary fat in growing chicks

Fuhrmann¹,

Sallmann²

1996

Br J Nutr

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Dietary fatty acids modify phospholipid fatty acids in brain and liver of growing chickens post-hatching. The effect of vitamin E deficiency on this process is unknown and may be relevant to the pathogenesis of chick nutritional encephalomalacia (NE). Therefore laying hens received a diet low in vitamin E (10 mg a-tocopherol/kg feed). Resulting chicks were assigned to nine dietary groups each fed with either oleic (18:ln-9, 58 g/kg), linoleic (18:2n-6, 57 g/kg) or linolenic (18:3n-3, 56 g/kg) acid together with 5, 25 or 125 mg a-tocopherol/kg feed. NE affecting the cerebellum only occurred in the group given linoleic acid and 5 mg a-tocopherol/kg. In l-d-old chicks and after 1 and 2 weeks the phospholipid fatty acid composition of liver, cerebrum and cerebellum (additionally after 3 weeks) was determined. The feed fatty acids were incorporated into the liver very efficiently during the first week of life. Unsaturation of liver membranes decreased in the order dietary linolenic > linoleic > oleic acid. In liver, also, the effect of a-tocopherol supplementation on phospholipid fatty acids was most pronounced. The unsaturation index increased during deficiency, whereas n-9 fatty acids decreased. In the chicken brain the alterations were delayed and less distinct. The cerebellum phospholipids were rich in n-9 fatty acids and as a whole more saturated in comparison with the cerebrum. Cerebellar unsaturation increased when linolenic or linoleic acid was given. However, NEproducing dietary conditions were not accompanied by specific alterations in cerebellar phospholipid fatty acids due to the a-tocopherol content of the diet. Rather the alterations of membrane fatty acids in the liver seem to play a role in the pathogenesis of NE.

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Vitamin E and Diabetes

1991

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Life expectancy of the diabetic has not been reduced so much by acute complications of insulin deficiency but rather through the development of vasculopathies. diseases of large and small vessels. The reasons for this disease are not well understood. However, recent studies demonstrate that protein, lipids, and nucleic acids become damaged in diabetes oxidatively. Therefore. it will be discussed in the following whether an increased "oxidative stress'' can explain the development of vascular complications in diabetes and which factors might be responsible for the augmented "oxidative stress" or the reduced capacity to compensate "oxidative stress". In line with the hypothesis that "oxidative stress" plays a significant role for development of vasculopathies in diabetes preliminary data suggest that the development of vascular complications in diabetes might be retarted or prevented by antioxidative treatment (Vitamin E. Vitamin c. Glutathion).

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Vitamin E Intake Affects Serum Thromboxane and Tissue Essential Fatty Acid Composition in the Rat

Cited by 6 publications

References 15 publications

Lipid peroxidation, prostacyclin and thromboxane A₂in pigs depleted of vitamin E and selenium and supplemented with linseed oil

Lipid peroxidation, prostacyclin and thromboxane A₂in pigs depleted of vitamin E and selenium and supplemented with linseed oil

Phospholipid fatty acids of brain and liver are modified by α-tocopherol and dietary fat in growing chicks

Vitamin E and Diabetes

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Vitamin E Intake Affects Serum Thromboxane and Tissue Essential Fatty Acid Composition in the Rat

Cited by 6 publications

References 15 publications

Lipid peroxidation, prostacyclin and thromboxane A2in pigs depleted of vitamin E and selenium and supplemented with linseed oil

Lipid peroxidation, prostacyclin and thromboxane A2in pigs depleted of vitamin E and selenium and supplemented with linseed oil

Phospholipid fatty acids of brain and liver are modified by α-tocopherol and dietary fat in growing chicks

Vitamin E and Diabetes

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Product

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Lipid peroxidation, prostacyclin and thromboxane A₂in pigs depleted of vitamin E and selenium and supplemented with linseed oil

Lipid peroxidation, prostacyclin and thromboxane A₂in pigs depleted of vitamin E and selenium and supplemented with linseed oil