Vitamin E inhibits the release of calcium from a platelet membrane fraction in vitro

Butler, Alison; Gerrard, Jon M.; Peller, Janet D.; Stoddard, S.F.; Rao, Gundu H. R.; White, James G.

doi:10.1016/0161-4630(79)90037-5

Cited by 39 publications

(3 citation statements)

References 32 publications

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“…Increased deacylation of phospholipids has been reported in platelets from vitamin E-deficient rabbits. 25 The in vitro addition of vitamin E to platelet membrane fractions has been shown to decrease calcium release from the membrane, 26 which would presumably decrease phospholipase activity.…”

Section: Discussionmentioning

confidence: 99%

Interrelation of Platelet Vitamin E and Thromboxane Synthesis in Type I Diabetes Mellitus

et al. 1984

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Platelet vitamin E content and thromboxane A2 (TxA2) synthesis have been investigated in type I diabetic subjects and age- and sex-matched controls. Platelets, but not plasma, from diabetic subjects contained significantly lower vitamin E levels and synthesized significantly greater amounts of TxA2 when challenged with collagen or thrombin than platelets from control subjects. Conversion of exogenously added arachidonic acid to TxA2 was unaltered between platelets from control and diabetic groups. Platelet vitamin E content from control and diabetic groups combined exhibited a significant negative linear correlation with collagen- and thrombin-induced TxA2 production. These data suggest that low platelet vitamin E levels could be a contributing factor to the increased thromboxane synthesis demonstrated by platelets from the above type I diabetic subjects.

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Section: Discussionmentioning

confidence: 99%

Interrelation of Platelet Vitamin E and Thromboxane Synthesis in Type I Diabetes Mellitus

et al. 1984

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“…Jandak and coworkers demonstrated that reduced platelet aggregation following vitamin E treatment correlates with the inability of platelets to form pseudopodia (60). Analagous to the reported inhibitory effect of vitamin E on endothelial cells, a variety of different mechanisms of action have been proposed, including reduced lipid peroxidation and generation of proaggregatory thromboxane (47), inhibition of phospholipase A 2 (25) and protein kinase C (86), and reduced mobilization of intracellular calcium (15).…”

Section: Plateletsmentioning

confidence: 99%

Vitamin E: Focus on Microcirculation

Lehr

VAJKOCZY

Menger³

1998

Microcirculation

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Note. Vitamin E is the generic term for all tocopherols and tocotrienols having qualitatively the biological activity of RRRalpha-tocopherol (previously known as d-alpha-tocopherol). Alpha-tocopherol has the highest biological activity. Other major forms include beta-and gamma-tocopherol and alphatocotrienol. All-rac-alpha-tocopherol (previously known as dlalpha-tocopherol) is the synthetic form of vitamin E. Vitamin E activity in clinical trials has often been expressed as IU (International Units). One IU = 1 mg all-rac-alpha-tocopherol acetate = 0.74 mg RRR-alpha-tocopheryl acetate = 0.67 mg .

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“…In platelets, vitamin E has been shown to inhibit phospholipase and calcium ion mobilization (Butler et al 1979). So, the release of arachidonic acid (AA) is enhanced from the diabetic platelet membrane containing reduced vitamin E content on platelet activation, and AA is used as a substrate of platelet prostaglandin metabolism, which enhances aggregation.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin E on platelet aggregation in diabetes mellitus.

Watanabe

Umeda

Wakasugi

et al. 1984

Tohoku J. Exp. Med.

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Vitamin E is known to be an inhibitor of platelet prostaglandin production and aggregation. The rate of platelet aggregation induced by adenosine diphosphate was significantly increased in diabetics with proliferative retinopathy, and the enhanced production of thromboxane B2i a stable metabolite of thromboxane A2, was demonstrated in those patients. On the other hand, vitamin E was significantly reduced in platelets obtained from diabetics as compared to age matched control subjects. In addition, it was shown that vitamin E content in platelets examined in diabetic and control subjects inversely correlated with both the rate of platelet aggregation and thromboxane B2 production during aggregation. It is suggested that the reduced vitamin E levels in diabetic platelets can contribute to the mechanisms of the enhanced platelet thromboxane A2 production and aggregation which lead to the development of vascular complications. vitamin E ; platelet aggregation ; thromboxane B2 ; diabetic retinopathy

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Vitamin E inhibits the release of calcium from a platelet membrane fraction in vitro

Cited by 39 publications

References 32 publications

Interrelation of Platelet Vitamin E and Thromboxane Synthesis in Type I Diabetes Mellitus

Interrelation of Platelet Vitamin E and Thromboxane Synthesis in Type I Diabetes Mellitus

Vitamin E: Focus on Microcirculation

Effect of vitamin E on platelet aggregation in diabetes mellitus.

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