Vitamin E in the Genesis and Prevention of Cancer a Review

Das, Sukta

doi:10.3109/02841869409121771

Cited by 61 publications

(27 citation statements)

References 42 publications

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“…However, it does appear to be the least toxic of the fatsoluble vitamins. No instances of toxicity have been reported at doses of 1600 mg per day tocopherol (Das, 1994). There are previous works on daily systemic treatment with this antioxidant at a dose of 2350 mg/kg in monkeys to prevent toxicity.…”

Section: Discussionmentioning

confidence: 99%

α-Tocopherol Protects Against Oxidative Stress in the Fragile X Knockout Mouse: an Experimental Therapeutic Approach for the Fmr1 Deficiency

Diego-Otero¹,

Romero-Zerbo²,

Bekay

et al. 2008

Neuropsychopharmacol

120

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Fragile X syndrome is the most common genetic cause of mental disability. The mechanisms underlying the pathogenesis remain unclear and specific treatments are still under development. Previous studies have proposed an abnormal hypothalamic-pituitary-adrenal axis and high cortisol levels are demonstrated in the fragile X patients. Additionally, we have previously described that NADPH-oxidase activation leads to oxidative stress in the brain, representing a pathological mechanism in the fragile X mouse model. Fmr1-knockout mice develop an altered free radical production, abnormal glutathione homeostasis, high lipid and protein oxidation, accompanied by stressdependent behavioral abnormalities and pathological changes in the first months of postnatal life. Chronic pharmacological treatment with a-tocopherol reversed pathophysiological hallmarks including free radical overproduction, oxidative stress, Rac1 and a-PKC activation, macroorchidism, and also behavior and learning deficits. The restoration of the oxidative status in the fragile X mouse emerges as a new and promising approach for further therapeutic research in fragile X syndrome.

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Section: Discussionmentioning

confidence: 99%

α-Tocopherol Protects Against Oxidative Stress in the Fragile X Knockout Mouse: an Experimental Therapeutic Approach for the Fmr1 Deficiency

Diego-Otero¹,

Romero-Zerbo²,

Bekay

et al. 2008

Neuropsychopharmacol

120

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show abstract

“…43) It is the most significant antioxidant of its kind in animal cells and can protect against carcinogenesis and tumor growth. 44) Vitamin C, which prevents oxidative damage to cell membrane induced by aqueous radicals also exists in interconvertible forms and participates in neutralizing free radicals. 45) In the present study, the lung cancer bearing animals showed decrease in the activities of enzymic antioxidants SOD, CAT, GPx, GST, GR and non-enzymic antioxidants GSH, vitamin E and vitamin C. Quercetin supplementation significantly increased all the above antioxidants which may be due to the ability of quercetin to interact with hydroxyl, superoxide, alkoxyl and peroxyl radicals thereby subsequently scavenging them.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Quercetin on Antioxidant Status and Tumor Markers in the Lung and Serum of Mice Treated with Benzo(a)pyrene

Kamaraj

Vinodhkumar

Anandakumar

et al. 2007

Biological & Pharmaceutical Bulletin

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Chemoprevention has emerged as a very effective preventive measure against carcinogenesis. Several bioactive compounds present in fruits and vegetables have revealed their cancer curative potential on benzo(a)pyrene (B(a)P) induced carcinogenesis. In the present study, the efficacy of quercetin on the level of lipid peroxides, activities of antioxidant enzymes and tumor marker enzymes in B(a)P induced experimental lung carcinogenesis in Swiss albino mice was assessed. In lung cancer bearing animals there was an increase in lung weight, lipid peroxidation and marker enzymes such as aryl hydrocarbon hydroxylase, gamma glutamyl transpeptidase, 5-nucleotidase, lactate dehydrogenase and adenosine deaminase with subsequent decrease in body weight and antioxidant enzymes-superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, reduced glutathione, vitamin E and vitamin C. Quercetin supplementation (25 mg/kg body weight) attenuated all these alterations, which indicates the anticancer effect that was further confirmed by histopathological analysis. Overall, the above data shows that the anticancer effect of quercetin is more pronounced when used as an chemopreventive agent rather than as a chemotherapeutic agent against B(a)P induced lung carcinogenesis.

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“…The recoupment of vitamin C to near normal level in drug treated mice was found to be due to the potent anticancer activity of the extract which may induce the regeneration of ascorbic acid. Vitamin E is the most significant antioxidant in animal cells and it can protect against carcinogenesis and tumor growth (Das, 1994). Significantly decreased vitamin E levels in ECA control animals might be due to the excessive utilization of this antioxidant for quenching enormous free radicals produced in these conditions.…”

Section: Discussionmentioning

confidence: 99%

Antitumor effect of Careya arborea against Ehrlich ascites carcinoma with reference to lipid peroxidation and enzymatic and non enzymatic antioxidant system in Swiss albino mice

Sambathkumar¹,

Sivakumar²,

Senthil³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe methanol extract of stem barks of Careya arborea Roxb. (MECA) (Family-Myrtaceae) was evaluated for antitumor activity and antioxidant status against Ehrlich's Ascites Carcinoma (EAC) bearing Swiss albino mice. After 24 h of tumor inoculation the MECA was administered at the doses of 50, 100 and 200 mg/kg body weight/mice/day for 14 days. After the last dose and 18 h fasting mice were sacrificed. The effect of MECA on the growth of transplantable murine tumor, life span of EAC bearing hosts, hematological profiles, serum and liver biochemical parameters were estimated. The MECA showed significant (P < 0.01) decrease in ascites volume, packed cell volume and viable cell count and prolonged the life span of EAC tumor bearing mice. Hematological profiles reverted to more or less normal levels in extract treated mice. The MECA also produced protective effect by decreasing the activity of serum enzymes, bilirubin and increase the protein and uric acid levels. MECA significantly (P < 0.05) decreased the levels of lipid peroxidation, while significantly (P < 0.05) increased the levels of glutathione content, vitamin C, vitamin E, superoxide dismutase and catalase CAT. The results indicate that MECA exhibited significant antitumor and antioxidant activity in EAC bearing mice.

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Vitamin E in the Genesis and Prevention of Cancer a Review

Cited by 61 publications

References 42 publications

α-Tocopherol Protects Against Oxidative Stress in the Fragile X Knockout Mouse: an Experimental Therapeutic Approach for the Fmr1 Deficiency

α-Tocopherol Protects Against Oxidative Stress in the Fragile X Knockout Mouse: an Experimental Therapeutic Approach for the Fmr1 Deficiency

The Effects of Quercetin on Antioxidant Status and Tumor Markers in the Lung and Serum of Mice Treated with Benzo(a)pyrene

Antitumor effect of Careya arborea against Ehrlich ascites carcinoma with reference to lipid peroxidation and enzymatic and non enzymatic antioxidant system in Swiss albino mice

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