Vitamin E in Sarkomen

Euler, B. V.; Euler, Hans v.

doi:10.1515/bchm2.1940.264.3-4.141

Cited by 5 publications

(3 citation statements)

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“…The results obtained with the goldfish intestine following exposure to acetylcholine confirm those previously reported by others (1)(2)(3). The effects of physostigmine and neostigmine were similar to the observations of Dreyer (1).…”

Section: Discussionsupporting

confidence: 91%

Influence of Physostigmine and Neostigmine on the Responses of Goldfish Intestine to Acetylcholine

Haley

Colvin

Efros

1964

Journal of Pharmaceutical Sciences

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Section: Discussionsupporting

confidence: 91%

Influence of Physostigmine and Neostigmine on the Responses of Goldfish Intestine to Acetylcholine

Haley

Colvin

Efros

1964

Journal of Pharmaceutical Sciences

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“…Other workers have arrived at a similar conclusion from experimental investigations of monoamine oxidase activity in relation to adrenergic stimulation of various effector organs in mammals [Gounard, Schmitt & Glikman, 1955;Corne & Graham, 1957], or from studies of circulating or excreted amines after inhibition of m.o. [Celander & Mellander, 1955;von Euler & Zetterstrom, 1955]. It must be pointed out, however, that there is also evidence showing that M.o.…”

Section: Discussionmentioning

confidence: 98%

Monoamine Oxidase, Thyroid Activity and Hyperglycaemia in the Frog

Smith¹

1959

Journal of Endocrinology

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1. Estimations of monoamine oxidase (m.o.) activity in suspensions of frog liver taken at monthly intervals showed that activity was relatively constant during the greater part of the year (mean value 8\m=.\6\ m=+-\ 0\m=.\332 \g=m\l .O2/15 min/mg colloid nitrogen), but it rose to a significantly higher level from August to November inclusive (mean 11\m=.\7\ m=+-\ 0\m=.\513\g=m\l .O2/15 min/mg colloid nitrogen).2. The pattern of seasonal variation in enzyme activity showed no correspondence with the annual cycle of change in the thyroid gland, nor was there any correlation between m.o. activity of the liver and the histological appearance of the thyroid in individual frogs.3. Inhibition of m.o. in vivo by iproniazid elicited a hyperglycaemic response to excitement in previously unresponsive frogs which was almost identical with that obtained after treatment with thyroxine and iproniazid.4. There was no evidence that treatment with thyroxine led to any alteration in the activity of liver m.o.5. It is concluded that m.o. is not an important factor in the inactivation of catechol amines in the strongly stimulated frog, but the possibility is discussed that under natural conditions of lower stress the high enzyme activity from August to November might be one factor tending to limit mobilization of liver glycogen.The general field of our knowledge of amine inactivation by monoamine oxidase under physiological conditions has recently been reviewed by Davison [1958]. The present paper, however, is mainly concerned with the long-established finding that removal of the thyroid gland from various mammals leads to a marked reduction in the hyperglycaemia following injection of adrenaline, while thyroid feeding enhances this response [Burn & Marks, 1925]. Spinks & Burn [1952] extended the scope of this work when they determined the monoamine oxidase (µ.o.) activity in suspensions of fiver from rabbits and rats in widely different, experimentally induced, thyroid states. They found a significant increase in activity after thyroidectomy, and therefore attributed the decreased sensitivity to adrenaline shown by such animals to the accelerated oxidation of the amine by M.o. This view, however, was not supported by Holtz, Stock & Westermann [1956], as they found that M.o. activity of liver extracts was either increased or not significantly altered when rabbits, guinea-pigs and rats were treated with thyroxine or triiodothyronine. As the frog is an animal which naturally shows wide seasonal fluctuations in thyroid activity coupled with marked changes in the hyperglycaemic response to adrenaline or excitement [Smith, 1954], it was obviously a very suitable animal for a further investigation of a possible association between the thyroid hormone and M.o. The present paper includes the results of a seasonal survey of M.o. activity in the liver of the frog, together with experimental observations on the effects of inhibiting the enzyme or administering thyroid hormone. iq Endoc 19 4

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“…Bovine splenic nerve granules were isolated by differential centrifugation with some modifications (Maitre, Staehelin & Bein, 1970) of the methods described by Euler (1958) and by Schumann (1958). Briefly, the procedure consists of incubating suspensions of the granule fractions at 37" for 20 min in a medium containing 0-3 M sucrose, 0.009 M sodium phosphate buffer pH 6.8, 0.003 M ATP, 0.003 M MgCl, and 0.1 mM ( f)-[3H]noradrenaline (0-12 ,uCi/pg).…”

Section: Estimation Of [3h]noradrenaline Uptake Into Isolated Bovine mentioning

confidence: 99%

Antihypertensive and noradrenaline-depleting effects of guanethidine metabolites

Maître

Staehelin

Brunner

1971

Journal of Pharmacy and Pharmacology

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The antihypertensive and myocardial noradrenaline-depleting activities of the three identified guanethidine metabolites were compared with those of guanethidine itself. Metabolite A (guanethidine-N-oxide) and Metabolite B [2-(6-~arboxylamino)ethylguanidine] both showed approximately 1 /30th of the antihypertensive effect of guanethidine in rats. Metabolite A, but not Metabolite B, caused a depletion of cardiac noradrenaline stores. The intensity of this effect was between l/lOth and 1/30th that of guanethidine. Metabolite C [(6-carboxyhexyl)-2-iminoimidazolidine] was inactive on both parameters. rH1Noradrenaline uptake into isolated bovine nerve granules was not impaired by either guanethidine or its metabolites. It is concluded that the antihypertensive and myocardial noradrenaline depleting effects of guanethidine are produced by the unchanged drug rather than by one of the identified metabolites.Guanethidine is widely used as an antihypertensive drug as well as a pharmacological research tool in the study of peripheral adrenergic mechanisms. Investigations have been made in the rat and in man on its excretion, distribution or metabolism or both (Dollery,The present investigation was undertaken to determine the influence of these metabolites on arterial blood pressure of renal hypertensive rats and on noradrenaline storage mechanisms. Antihypertensive efectsRenal hypertension was produced in male rats, of 120-140 g, according to Goldblatt, by clamping the left renal arterial with silver clips (lumen 0.2 mm). Systolic blood pressure was measured under light ether anaesthesia by the plethysmographic method MATERIALS A N D METHODS

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Vitamin E in Sarkomen

Cited by 5 publications

References 0 publications

Influence of Physostigmine and Neostigmine on the Responses of Goldfish Intestine to Acetylcholine

Influence of Physostigmine and Neostigmine on the Responses of Goldfish Intestine to Acetylcholine

Monoamine Oxidase, Thyroid Activity and Hyperglycaemia in the Frog

Antihypertensive and noradrenaline-depleting effects of guanethidine metabolites

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