1974
DOI: 10.1016/s0140-6736(74)92434-9
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Vitamin E in Clinical Medicine

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Cited by 9 publications
(2 citation statements)
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“…These results suggest that the intravenous adminis tration of pharmacologic amounts of vita min E in a P vehicle, or P alone affect lipid metabolism. Kellner et al [12] observed sus tained elevations of blood cholesterol, phos pholipid and neutral fat in rabbits following the intravenous injection of P. In humans, large doses of vitamin E (up to 3 g/day) have resulted in elevated cholesterol [ 13] and tri glyceride levels [13,14], We speculate that the lipidosis or fatty change seen in the organs of the HE-fed, T-or TA-treated groups could be the result of an interaction between T or TA and P. The potential toxi cologic significance of this observation is not known.…”
Section: Discussionmentioning
confidence: 99%
“…These results suggest that the intravenous adminis tration of pharmacologic amounts of vita min E in a P vehicle, or P alone affect lipid metabolism. Kellner et al [12] observed sus tained elevations of blood cholesterol, phos pholipid and neutral fat in rabbits following the intravenous injection of P. In humans, large doses of vitamin E (up to 3 g/day) have resulted in elevated cholesterol [ 13] and tri glyceride levels [13,14], We speculate that the lipidosis or fatty change seen in the organs of the HE-fed, T-or TA-treated groups could be the result of an interaction between T or TA and P. The potential toxi cologic significance of this observation is not known.…”
Section: Discussionmentioning
confidence: 99%
“…Per haps the earliest was that of Marx et al [1] who reported that tocopherol administration caused atherogenesis in rats. Dahl [2] found that in 52 patients ingesting 300 mg/day of a-tocopherol. the serum cholesterol rose by an average of 74 mg/100 ml (2 mmol/1).…”
Section: Introductionmentioning
confidence: 99%