Vitamin E in Clinical Medicine

Dahl, Sven

doi:10.1016/s0140-6736(74)92434-9

Cited by 9 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results suggest that the intravenous adminis tration of pharmacologic amounts of vita min E in a P vehicle, or P alone affect lipid metabolism. Kellner et al [12] observed sus tained elevations of blood cholesterol, phos pholipid and neutral fat in rabbits following the intravenous injection of P. In humans, large doses of vitamin E (up to 3 g/day) have resulted in elevated cholesterol [ 13] and tri glyceride levels [13,14], We speculate that the lipidosis or fatty change seen in the organs of the HE-fed, T-or TA-treated groups could be the result of an interaction between T or TA and P. The potential toxi cologic significance of this observation is not known.…”

Section: Discussionmentioning

confidence: 99%

Toxicity Studies of Intravenous Vitamin E in Newborn Rabbits

Rivera

Abdo²,

Bucher³

et al. 1990

Dev Pharmacol Ther

View full text Add to dashboard Cite

This study was designed to investigate the toxicity of intravenously administered alpha-tocopherol, alpha-tocopheryl acetate, and a polysorbate vehicle similar to that used in a commercial preparation of alpha-tocopheryl acetate intended for intravenous administration. Cesarean-delivered newborn rabbits fed intravenously were administered 100 mg of either alpha-tocopherol or alpha-tocopheryl acetate in a polysorbate vehicle, or the vehicle only, or no treatment for 6 or 7 days. Two intravenous diets were employed which differed in nutritional content and were termed low energy (LE) and high energy (HE). High concentrations of alpha-tocopherol were present in the tissues of all pups that received either treatment with alpha-tocopherol or alpha-tocopheryl acetate in the polysorbate vehicle, irrespective of the nutritional regimen. Pups in all treatment and control groups which received the LE diet had hepatic centrilobular degeneration, necrosis and pigment accumulation, which was attributed to malnutrition. No additional toxicities could be attributed to the vitamin E or polysorbate treatments. Administration of the HE diet eliminated the nutritionrelated centrilobular degeneration, and revealed treatment-related liver changes. HE pups treated with alpha-tocopheryl acetate in the polysorbate vehicle had microscopic evidence of mild bile stasis and had elevated serum bilirubin. Minimal lipidosis or fatty change in the liver was observed only in alpha-tocopherol and alpha-tocopheryl acetate-treated pups. Lipidosis in the spleen was moderate in the alpha-tocopherol group and minimal in the alphatocopheryl acetate group. Lipidosis also occurred in the adrenal gland primarily in the alpha-tocopheryl acetate group. These studies suggest that alpha-tocopherol and alpha-tocopheryl acetate in a polysorbate vehicle may be mildly hepatotoxic and may affect fat metabolism.

show abstract

Section: Discussionmentioning

confidence: 99%

Toxicity Studies of Intravenous Vitamin E in Newborn Rabbits

Rivera

Abdo²,

Bucher³

et al. 1990

Dev Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Per haps the earliest was that of Marx et al [1] who reported that tocopherol administration caused atherogenesis in rats. Dahl [2] found that in 52 patients ingesting 300 mg/day of a-tocopherol. the serum cholesterol rose by an average of 74 mg/100 ml (2 mmol/1).…”

Section: Introductionmentioning

confidence: 99%

Vitamin E and Lipogenesis in the Mammalian Liver

Candlish¹

1982

Ann Nutr Metab

View full text Add to dashboard Cite

Mice on tocopherol-supplemented and cod-liver oil-enriched diets were given intraperitoneal injections of tritiated water. The fatty acids and cholesterol from their livers were then extracted and counted. Tocopherol supplementation depressed fatty acid but not cholesterol synthesis. Cod-liver oil (a vitamin E antagonist) elevated fatty acid but not cholesterol synthesis. In both cases, these effects were cancelled or reversed after about 20 days’ ingestion of the diet.

show abstract

Nutzen und Gefahren hochdosierter Vitamin E‐Präparate

Elmadfa

1985

Fette, Seifen, Anstrichm.

View full text Add to dashboard Cite

Wie kein anderes Vitamin erfiihrt Vitamin Ez.Z. einen noch niegekannten, durch massive Propagierung erst moglich gewordenen Einsatz als Phar makon zur therapeutischen Behandlung oder Vorbeugung nahezu aller erdenklichen Erkrankungen und Gebrechen beim Menschen. Hierbei werden so hohe Dosen eingenommen, die oft die wiinschenswerte Zufuhr (12 mg D-a-Toc.-aquivJd) um das zehn-bis iibersechzigfacheiiberschreiten.1nden meisten Faillen jedoch stiitzt man sich, mangels unmittelbarer Indikationen, aufBeobachtungenanVersuchtstiereninverschiedenenS tadienexperimentellen Vitamin-E-Mangels. Da ein primiirer Vitamin-E-Mangel beim Menschen nicht bekannt ist, kann im Falle solcher Dosierungen nicht von einer Substitutionstherapie gesprochen werden. Indiziert ist der therapeutische Einsatz hochdosierterPrs'parate lediglichin wenigen Fd1en;vorallem bei Patienten mit Fettmaldigestion und malabsorption infolge von Pancreas-und Gallenfunktionsstorungen, bei A-P-Lipoproteiniimie, bei der Behandlung von Friihgeborenenanimie sowie bei derclaudicatio intermittens. Bei Dosierungen bis 200 mg D-a'lbcopherolaquivalenten iiber wenige Wochen wurden beim Menschen bisher keine Abnormalitaten beobachtet. Hohere Dosen verursachten Abnahmen des Gehalts der Schilddriisenhormone im Blut, vermehrte Steroidausscheidung im Urin. Muskelschwache und Miidigkeit,visuelleStorungen,VerschlechterungvonDiabetes mellitus und Angina pectoris, Potenzierung der Wirkung derAntikoagulantien vom Cumarin-Typ und wirkten einer Eisentherapie bei der Behandlung von Eisenmangelanimien entgegen u. a. Bei Tieren fiihrten hohe Tocopheroldosen zur Steigerung des Bedarfs an Vitaminen A, D und K, zu Storungen von Membranen, Teilen des endokinen Systems und des Muskelstoffwechsels sowie zu Wachstumverzogerungen und zum Tod. Davitamin E im Korper gespeichert wird und seine pharmakodynamischen Wirkungen noch nicht geklart sind, sind die Folgen der Einnahme hochdosierter Prs'parate nur schwer kalkulierbar.

show abstract

Vitamin E in Clinical Medicine

Cited by 9 publications

References 0 publications

Toxicity Studies of Intravenous Vitamin E in Newborn Rabbits

Toxicity Studies of Intravenous Vitamin E in Newborn Rabbits

Vitamin E and Lipogenesis in the Mammalian Liver

Nutzen und Gefahren hochdosierter Vitamin E‐Präparate

Contact Info

Product

Resources

About