Vitamin E does not slow the progression of hypercholesterolemic atherosclerosis

Prasad, Kailash

doi:10.1055/s-0031-1278333

Cited by 8 publications

(4 citation statements)

References 44 publications

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“…We found no significant difference in serum lipid and CRP levels between TEMF and placebo groups. Other studies supplementing vitamin E or tocotrienolenriched mixed fraction after high cholesterol diet insult, also reported no significant effect of the treatment on serum lipid and oxidative stress markers (Prasad, 2009;Abdul Rahman et al, 2016).…”

Section: Serum Lipid and C-reactive Protein (Scrp)mentioning

confidence: 95%

Preventive Effects of Tocotrienol-Enriched Mixed Fraction on Plaque Formation and Stability in Early and Established Atherosclerosis

Omar

MUHAMMAD

BAKAR

et al. 2022

MABJ

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Atherosclerosis is the underlying pathology for cardiovascular disease. The preventive effects of tocotrienol-enriched mixed fraction (TEMF) on atherogenesis remains unclear. Objective: To investigate the preventive effects of TEMF supplementation on early and established atherosclerosis. Methods: Twenty New Zealand white rabbits were divided into TEMF (n=10) and placebo (n=10) groups. Treatments were given by oral gavage for 8 weeks followed by 1% high cholesterol diet (HCD) for another two (to induce early atherosclerosis) or eight weeks (established atherosclerosis). At the end of the study, the aorta was dissected, stained with Sudan IV, and qualitatively analysed for the atherosclerotic lesion. Immunohistochemistry was performed to detect expression of interleukin-6 (IL-6), CRP, nuclear factor kappa beta, E-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion protein-1 (VCAM-1), smooth muscle actin (SMA) and matrix metalloproteinase-12 (MMP-12). Results: In both early and established atherosclerosis groups, there was a significant reduction of atherosclerotic lesions in TEMF compared to placebo. Atherogenic biomarkers; IL-6, CRP, E-selectin, SMA, and MMP-12 were reduced with TEMF supplementation in established atherosclerosis (p<0.05). Neutral effects were seen in early atherosclerosis group. TEMF supplementation in the preventive setting decreased atherosclerosis formation and reduces endothelial inflammation in established atherosclerosis lesions, while increasing plaque stability.

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Section: Serum Lipid and C-reactive Protein (Scrp)mentioning

confidence: 95%

Preventive Effects of Tocotrienol-Enriched Mixed Fraction on Plaque Formation and Stability in Early and Established Atherosclerosis

Omar

MUHAMMAD

BAKAR

et al. 2022

MABJ

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“…Recently, a controlled experimental study in rabbits was carried out by Prasad [79] to clarify the controversy if vitamin E slows the progression of atherosclerosis. This study was designed to investigate if vitamin E slows the progression of established atherosclerosis and if this effect is associated with reductions in serum lipids and oxidative stress.…”

Section: Slowing Of Progression Of Atherosclerosismentioning

confidence: 99%

Natural Products in Regression and Slowing of Progression of Atherosclerosis

Prasad

2010

CPB

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Many natural products, including vitamin E, garlic, purpurogallin, flaxseed and its components [secoisolariciresinol diglucoside (SDG) and flax lignan complex (FLC)] and resveratrol have been reported to suppress hypercholesterolemic atherosclerosis. It is known that all of the drugs that suppress the development of atherosclerosis do not regress and/or slow the progression of atherosclerosis. To be of potential benefit in patients with established atherosclerosis, a drug should produce regression and/or slow the progression of atherosclerosis. In this review, the effects of vitamin E, SDG and FLC in the regression and slowing of progression of hypercholesterolemic atherosclerosis and their mechanisms have been described. The effectiveness of vitamin E in patients with established coronary disease is very controversial. However, in experimental animal controlled studies, vitamin E does not regress or slow the progression of hypercholesterolemic atherosclerosis. The mechanisms of the ineffectiveness of vitamin E in regression and slowing of progression of atherosclerosis have been discussed. SDG is effective in slowing the progression of atherosclerosis and partially effective in regression of hypercholesterolemic atherosclerosis. These effects are associated with reduction in oxidative stress. FLC does not regress hypercholesterolemic atherosclerosis but slows the progression of hypercholesterolemic atherosclerosis. Slowing of progression is associated with reduction on oxidative stress. In conclusion, vitamin E does not regress or slow the progression of established atherosclerosis. SDG slows the progression and regresses established atherosclerosis. FLC does not regress but slows the progression of established atherosclerosis.

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“…Numerous studies have focused on the utility of antioxidant supplementation in the treatment of cardiovascular diseases [ 2 ]. Yet, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate for evidence is inconclusive [ 3 – 9 ]. Observational studies of vitamins C and E, the most prevalent natural antioxidant vitamins, suggest that supplemental use of these vitamins may lower the risk for coronary events [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidants Supplementation in Elderly Cardiovascular Patients

Otero‐Losada

Vila

Azzato

et al. 2013

Oxidative Medicine and Cellular Longevity

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Supplementation with antioxidants and its benefit-risk relationship have been largely discussed in the elderly population. We evaluated whether antioxidants supplementation improved the biochemical profile associated with oxidative metabolism in elderly cardiovascular patients. Patients (n = 112) received daily supplementation with α-TP 400 mg, beta-carotene 40 mg, and vitamin C 1000 mg for 2 months (treatment). Plasma concentrations of alpha-tocopherol (α-TP), β-carotene (βC), ubiquinol-10 (QH-10), glutathione, and thiobarbituric acid reactive substances (TBARS) were determined before and after treatment. Response to treatment was dependent on pretreatment α-TP and βC levels. Increase in α-TP and βC levels was observed only in patients with basal levels <18 μM for α-TP (P < 0.01) and <0.30 μM for βC (P < 0.02). Ubiquinol-10, glutathione, and TBARS were unaffected by treatment: QH-10 (+57%, F 1,110 = 3.611, P < 0.06, and N.S.), glutathione (+21%, F 1,110 = 2.92, P < 0.09, and N.S.), and TBARS (−29%, F 1,110 = 2.26, P < 0.14, and N.S.). Treatment reduced oxidative metabolism: 5.3% versus 14.6% basal value (F 1,110 = 9.21, P < 0.0003). Basal TBARS/α-TP ratio was higher in smokers compared to nonsmokers: 0.11 ± 0.02 versus 0.06 ± 0.01 (F 32,80 = 1.63, P < 0.04). Response to antioxidant supplementation was dependent on basal plasma levels of α-TP and βC. Smoking status was strongly associated with atherosclerotic cardiovascular disease and high TBARS/α-TP ratio (lipid peroxidation).

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Vitamin E does not slow the progression of hypercholesterolemic atherosclerosis

Abstract: Vitamin E did not slow the progression of hypercholesterolemic atherosclerosis, and this effect was associated with its ineffectiveness in reducing serum lipids and oxidative stress.

Cited by 8 publications

References 44 publications

Preventive Effects of Tocotrienol-Enriched Mixed Fraction on Plaque Formation and Stability in Early and Established Atherosclerosis

Preventive Effects of Tocotrienol-Enriched Mixed Fraction on Plaque Formation and Stability in Early and Established Atherosclerosis

Natural Products in Regression and Slowing of Progression of Atherosclerosis

Antioxidants Supplementation in Elderly Cardiovascular Patients

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