Vitamin E Does Not Modify HDL-Cholesterol

Howard, Donald; Rundell, Clark; Batsakis, John G.

doi:10.1093/ajcp/77.1.86

Cited by 21 publications

(8 citation statements)

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“…Hermann et al (30) supplemented human subjects with 600 IU of = -tocopherol for 30 days; an increase in HDLcholesterol and no change in triglycerides or total cholesterol occurred. These results were not confirmed by other investigators who used the same experimental protocol (31,32).…”

Section: Resultscontrasting

confidence: 86%

Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

Peluzio

Homem

César

et al. 2001

Braz J Med Biol Res

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Although the role of oxidized lipoproteins is well known in atherogenesis, the role of vitamin E supplementation is still controversial. There is also little information about cholesterol metabolism (hepatic concentration and fecal excretion) in the new models of atherosclerosis. In the present study, we evaluated the effect of moderate vitamin E supplementation on cholesterol metabolism and atherogenesis in apolipoprotein E (apo E)-deficient mice. Apo E-deficient mice were fed an atherogenic diet containing 40 or 400 mg/kg of = -tocopherol acetate for 6 weeks. Total cholesterol in serum and liver and 3-OH-=-sterols in feces, and fecal excretion of bile acids were determined and histological analyses of aortic lesion were performed. A vitamin Erich diet did not affect body weight, food intake or serum cholesterol. Serum and hepatic concentrations of cholesterol as well as sterol concentration in feces were similar in both groups. However, when compared to controls, the = -tocopherol-treated mice showed a reduction of about 60% in the atherosclerotic lesions when both the sum of lesion areas and the average of the largest lesion area were considered. These results demonstrate that supplementation of moderate doses of = -tocopherol was able to slow atherogenesis in apo E-deficient mice and to reduce atherogenic lipoproteins without modifying the hepatic pool or fecal excretion of cholesterol and bile acids.

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Section: Resultscontrasting

confidence: 86%

Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

Peluzio

Homem

César

et al. 2001

Braz J Med Biol Res

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“…A hypocholesterolemic effect of vitamin E has been previously reported in rats 48 and rabbits. 10,14,15,17,49 Significant changes in serum cholesterol concentrations have not been reported in human subjects receiving vitamin E supplements 50,51 ; however the doses of vitamin E used in human studies (600 to 800 mg/d per person) were far lower than those used in animal studies. Vitamin E probably lowers serum cholesterol by increasing the activity of cholesterol 7␣-hydroxylase, 49,52 the enzyme responsible for controlling the rate at which hepatic cholesterol is converted to bile acids.…”

Section: Discussionmentioning

confidence: 99%

Dietary Antioxidants Do Not Reduce Fatty Streak Formation in the C57BL/6 Mouse Atherosclerosis Model

Munday

Thompson

James

et al. 1998

ATVB

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Abstract-Epidemiological studies and animal trials have suggested that dietary antioxidants protect against atherosclerosis. To test this hypothesis, C57BL/6 mice were fed atherogenic diets supplemented with either vitamin E or butylated hydroxytoluene (BHT). Three groups of 20 mice were fed for 15 weeks on diets containing 1% cholesterol and 0.5% cholic acid. The diet of two groups was supplemented with either 2% vitamin E or 1% BHT. The control group received no antioxidant supplements. The lowest mean serum cholesterol concentration was measured in mice supplemented with vitamin E. Mean serum HDL cholesterol concentrations were highest in the control group, which also had the highest ratio of HDL cholesterol to total cholesterol. Mice fed BHT developed a significantly greater area of aortic fatty streak lesions than the other two groups. However, despite having a more atherogenic lipoprotein profile, mice fed vitamin E developed a level of fatty streak formation similar to the control group. At the end of the trial, mice consuming the vitamin E-and BHT-supplemented diets had higher serum total antioxidant levels than the control mice. Because of changes to lipid metabolism caused by both vitamin E and BHT, the results of this study cannot be used to support the hypothesis that antioxidants confer protection against atherosclerosis. The results do, however, raise the possibility that other studies demonstrating an antiatherogenic action of vitamin E and BHT may have been influenced by their effects on lipid metabolism. (Arterioscler Thromb Vasc Biol. 1998;18:114-119.)

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“…Several studies reported that vitamin E increased cholesterol levels in the HDL [3,50]. Other studies reported that vitamin E had little effect on plasma lipoproteins [4,51], and still other studies reported that vitamin E increased cholesterol levels in the VLDL and LDL [5,28]. But recent studies indicate that antioxidants actually hampered the body's fight against damaging cholesterol.…”

Section: Resultsmentioning

confidence: 99%

“…Nowadays, there are several different hypotheses about the effect of antioxidant vitamins on serum cholesterol. Cholesterol homeostasis is closely related to plasma lipoprotein metabolism [1,2], and a number of studies have provided ambiguous data on the relationships between vitamin E and the cholesterol distribution and concentration in plasma lipoproteins [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Does Dietary vitamin E or C Decrease Egg Yolk Cholesterol?

Mohiti-Asli

Zaghari

2010

Biol Trace Elem Res

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An experiment was conducted to determine the effect of dietary vitamin E and C on serum metabolites, yolk cholesterol, egg quality, and performance of layer hens. One hundred sixty-eight commercial Hy-Line W-36 layer hens were randomly divided into seven groups and six replicates with four hens in each. Dietary treatments were introduced after the pre-experimental period (10 days) to adjust egg production. Treatments were levels of vitamin E or C (100, 200, and 400 mg/kg diet) supplementation to the basal diet for 4 weeks, whereas the control group received no supplementation. Egg production, egg weight, and feed consumption were recorded during the study. Shell thickness, Haugh unit score, yolk color, yolk weight, yolk cholesterol, and blood parameters were measured at the end of experiment. There was no significant effect of dietary vitamin E or C on hen performance. Egg yolk cholesterol concentrations decreased linearly by antioxidant vitamin supplementation (P < 0.01). Egg yolk cholesterol reduction did not have any negative effect on egg production rate. Antioxidants, especially vitamin C, increased serum glucose concentration (P < 0.05). Serum total cholesterol content did not change by vitamin supplementation but cholesterol in high-density lipoprotein (HDL-C) decreased and cholesterol in low-density lipoprotein (LDL-C) increased (P < 0.05), as dietary vitamin E or C supplementation increased in diets. These results are in conflict with the previous hypothesis that antioxidants have a role in LDL-C removal from the blood or increasing HDL-C. Vitamin E was more effective than vitamin C in this case and if these results are confirmed by further studies, they may result to revision in researchers' point of view about antioxidant especially in human medicine.

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Vitamin E Does Not Modify HDL-Cholesterol

Cited by 21 publications

References 0 publications

Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

Influences of alpha-tocopherol on cholesterol metabolism and fatty streak development in apolipoprotein E-deficient mice fed an atherogenic diet

Dietary Antioxidants Do Not Reduce Fatty Streak Formation in the C57BL/6 Mouse Atherosclerosis Model

Does Dietary vitamin E or C Decrease Egg Yolk Cholesterol?

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