Vitamin E delta-tocotrienol and metabolite 13’-carboxychromanol inhibit colitis-associated colon tumorigenesis and modulate gut microbiota in mice

Yang, Chao; Zhao, Yiying; Im, Suji; Nakatsu, Cindy H.; Jones-Hall, Yava L.; Jiang, Qing

doi:10.1016/j.jnutbio.2020.108567

Cited by 37 publications

(38 citation statements)

References 39 publications

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“…Liu et al, 2021). In the same context, the effects of δtocotrienol and its LCMs on gut microbiota during tumorigenesis in mice were verified (C. Yang et al, 2021). The above work revealed a novel activity of δ-tocotrienol and its metabolite and suggested that δ-13ʹCOOH may play a role in the anticancer effect and gut microbe modulation activity of δ-tocotrienol.…”

Section: Biological Activity Of Vitamin E and Its Metabolitesmentioning

confidence: 72%

“…In colitis‐induced mice, γ‐tocopherol exerted a protective effect on the integrity of the gut barrier by attenuating the colitis‐induced increase in Lipopolysaccharide binding protein (LPS‐binding protein) in the plasma and caused a beneficial change in the gut microbiota (K. Y. Liu et al., 2021). In the same context, the effects of δ‐tocotrienol and its LCMs on gut microbiota during tumorigenesis in mice were verified (C. Yang et al., 2021). The above work revealed a novel activity of δ‐tocotrienol and its metabolite and suggested that δ‐13ʹCOOH may play a role in the anticancer effect and gut microbe modulation activity of δ‐tocotrienol.…”

Section: Vitamin E Chemistry and Metabolismmentioning

confidence: 95%

“…The two compounds promoted potentially beneficial Lactococcus and Bacteroides species. In addition, delta‐tocotrienol 13’‐carboxychromanol (δTE‐13ʹ) counteracted the azoxymethane/dextran‐sulfate‐sodium‐induced depletion of Roseburia , which is known to be reduced in patients with inflammatory bowel disease (C. Yang et al., 2021). This study is not the first to show that vitamin E metabolites, particularly LCMs, are more biologically active and potent than their precursors.…”

Section: Vitamin E Chemistry and Metabolismmentioning

confidence: 99%

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Vitamin E in foodstuff: Nutritional, analytical, and food technology aspects

Zaaboul

Liu

2022

Comp Rev Food Sci Food Safe

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Vitamin E is a group of isoprenoid chromanols with different biological activities. It comprises eight oil‐soluble compounds: four tocopherols, namely, α‐, β‐, γ‐, and δ‐tocopherols; and four tocotrienols, namely, α‐, β‐, γ, and δ‐tocotrienols. Vitamin E isomers are well‐known for their antioxidant activity, gene‐regulation effects, and anti‐inflammatory and nephroprotective properties. Considering that vitamin E is exclusively synthesized by photosynthetic organisms, animals can only acquire it through their diet. Plant‐based food is the primary source of vitamin E; hence, oils, nuts, fruits, and vegetables with high contents of vitamin E are mostly consumed after processing, including industrial processes and home‐cooking, which involve vitamin E profile and content alteration during their preparation. Accordingly, it is essential to identify the vitamin E content and profile in foodstuff to match daily intake requirements. This review summarizes recent advances in vitamin E chemistry, metabolism and metabolites, current knowledge on their contents and profiles in raw and processed plant foods, and finally, their modern developments in analytical methods.

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Section: Biological Activity Of Vitamin E and Its Metabolitesmentioning

confidence: 72%

Section: Vitamin E Chemistry and Metabolismmentioning

confidence: 95%

Section: Vitamin E Chemistry and Metabolismmentioning

confidence: 99%

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Vitamin E in foodstuff: Nutritional, analytical, and food technology aspects

Zaaboul

Liu

2022

Comp Rev Food Sci Food Safe

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“…The importance of vitamin E has also been highlighted by vaccinations: indeed, a supplementation of 200 IU/day of vitamin E (dl-α-tocopherol) is related to an improvement of the vaccines efficacy against tetanus and hepatitis B [81]. The most relevant function of vitamin E is its antioxidant effect, which may inhibit colon tumorigenesis and suppress the production of the proinflammatory cytokines in a murine model [82].…”

Section: Vitamin Ementioning

confidence: 99%

Vaccines, Microbiota and Immunonutrition: Food for Thought

et al. 2022

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Vaccines are among the most effective health measures and have contributed to eradicating some diseases. Despite being very effective, response rates are low in some individuals. Different factors have been proposed to explain why some people are not as responsive as others, but what appears to be of critical importance is the presence of a healthy functioning immune system. In this respect, a key factor in modulating the immune system, both in its adaptive and innate components, is the microbiota. While microbiota can be modulated in different ways (i.e., antibiotics, probiotics, prebiotics), an effective and somewhat obvious mechanism is via nutrition. The science of nutrients and their therapeutic application is called immunonutrition, and it is increasingly being considered in several conditions. Our review will focus on the importance of nutrition and microbiota modulation in promoting a healthy immune system while also discussing the overall impact on vaccination response.

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“…Gut microbiotasynthesized Vitamins B12 and folate are vital for red blood cells synthesis, and red blood cells are crucial for supplying oxygen to immune cells and participating in the defensive process against pathogens [158]. Vitamin E delta-tocotrienol and its metabolite 13′-carboxychromanol inhibit tumor-associated colitis by reduction of pro-inflammatory cytokines GM-CSF, MCP-1, and IL-1β, respectively [159].…”

Section: Immunity Microbial Metabolite and C Jejuni Interactionmentioning

confidence: 99%

The Role of Immune Response and Microbiota on Campylobacteriosis

Fu¹,

Alenezi²,

Almansour³

et al. 2022

Campylobacter

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Million cases of campylobacteriosis and complications of post-Campylobacter jejuni infection occur every year around the world with huge life losses and economic burdens of billions of dollars. Few therapy options, such as antibiotics, are available to relieve severe cases of the enteritis. The slow progression on new intervention discovery and application is partially resulted from limited mechanistic understanding on campylobacteriosis pathogenesis. As a type of intestinal disorders, campylobacteriosis shares many common features with other intestinal diseases such as inflammatory bowel diseases (IBD) and Clostridium difficile infection. In pace with the advancement of the gastroenterology field, a large body of knowledge is accumulating on the factors influencing campylobacteriosis onset, development, and outcomes, including host immune response, intestinal microbiota, and its metabolites. In this chapter, we review the intestinal immune system, intestinal microbiome, and microbiome modulation of inflammation in the development of campylobacteriosis. The interplay between immunity, microbiota, and its metabolites may play essential roles on campylobacteriosis pathogenesis and the finding on the interaction may lead to new prevention and treatment options. The purpose of this chapter is to provide updated knowledge on the role of host–microbe interaction and the therapeutic potential on campylobacteriosis.

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Vitamin E delta-tocotrienol and metabolite 13’-carboxychromanol inhibit colitis-associated colon tumorigenesis and modulate gut microbiota in mice

Cited by 37 publications

References 39 publications

Vitamin E in foodstuff: Nutritional, analytical, and food technology aspects

Vitamin E in foodstuff: Nutritional, analytical, and food technology aspects

Vaccines, Microbiota and Immunonutrition: Food for Thought

The Role of Immune Response and Microbiota on Campylobacteriosis

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