Vitamin E-Coated Dialyzer Inhibits Oxidative Stress

Yamadera, Shiho; Nakamura, Yuya; Inagaki, Masumi; Ohsawa, Isao; Gotoh, Hiromichi; Goto, Yoshikazu; Sato, Naoki; Oguchi, Tamio; Gomi, Yurika; Tsuji, Mayumi; Kiuchi, Yuji; Iwai, Shinichi

doi:10.1159/000478971

Cited by 12 publications

(10 citation statements)

References 14 publications

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“…In order to overcome this problem, antioxidative and biocompatible HD materials exemplified by the vitamin E-coated dialyzer have been developed. ( 15 – 17 ) However, despite the numerous advances in HD dialyzers, the prognosis of HD patients remains unsatisfactory, especially those with diabetes mellitus (DM), a disease that promotes a highly oxidative state. ( 18 )…”

Section: Introductionmentioning

confidence: 99%

“…In order to overcome this problem, antioxidative and biocompatible HD materials exemplified by the vitamin E-coated dialyzer have been developed. (15)(16)(17) However, despite the numerous advances in HD dialyzers, the prognosis of HD patients remains unsatisfactory, especially those with diabetes mellitus (DM), a disease that promotes a highly oxidative state. (18) These concerns are partly due to the fact that the details of widely varied and complexed in vivo oxidative stress-related reactions have not been sufficiently analyzed.…”

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confidence: 99%

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Hemodialysis raises oxidative stress through carbon-centered radicals despite improved biocompatibility

Hirayama

Akazaki

Nagano

et al. 2021

J. Clin. Biochem. Nutr.

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Leukocyte activation and the resulting oxidative stress induced by bioincompatible materials during hemodialysis impact the prognosis of patients. Despite multiple advances in hemodialysis dialyzers, the prognosis of hemodialysis patients with complica tions deeply related to oxidative stress, such as diabetes mellitus, remains poor. Thus, we re evaluated the effects of hemodialysis on multiple reactive oxygen species using electron spin resonance based methods for further improvement of biocompatibility in hemodialysis. We enrolled 31 patients in a stable condition undergoing hemodialysis using high flux polysulfone dialyzers. The effects of hemodialysis on reactive oxygen species were evaluated by two methods: MULTIS, which evaluates serum scavenging activities against multiple hydrophilic reactive oxygen species, and i STrap, which detects lipophilic carbon center radicals. Similar to previous studies, we found that serum hydroxyl radical scavenging activity significantly improved after hemodialysis. Unlike previous studies, we discovered that scavenging activity against alkoxyl radical was significantly reduced after hemodialysis. Moreover, patients with diabetes mellitus showed a decrease in serum scavenging activity against alkyl peroxyl radicals and an increase in lipophilic carbon center radicals after hemodialysis. These results suggest that despite extensive improvements in dialyzer membranes, the forms of reactive oxygen species that can be eliminated during dialysis are limited, and multiple reactive oxygen species still remain at increased levels during hemodialysis.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Hemodialysis raises oxidative stress through carbon-centered radicals despite improved biocompatibility

Hirayama

Akazaki

Nagano

et al. 2021

J. Clin. Biochem. Nutr.

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“…Consequently, polysulfone-based vitamin E-bonded membranes were developed [4-8] to achieve a synergistic effect of the biocompatibility of synthetic membranes and the antioxidant activity of vitamin E. This clinical study was designed to evaluate the vitamin E-bonded polysulfone hemodialyzer, ViE™-21, manufactured by Asahi Kasei Medical Co., Ltd., at a clinical site in Canada to obtain performance and safety data for regulatory submission.…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of performance, biocompatibility, and safety of vitamin E-bonded polysulfone membrane hemodialyzer compared to non-vitamin E-bonded hemodialyzer

et al. 2019

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The vitamin E-bonded polysulfone membrane hemodialyzer (ViE™-21) was evaluated in a clinical study for regulatory submission. Seventeen patients on hemodialysis were treated with conventional high-flux hemodialyzers for 2 weeks (Pre-ViE phase) and switched to the ViE-21 for 36 sessions (ViE phase) followed by an additional 2 weeks on conventional hemodialyzers (Post-ViE phase). Reduction ratios of urea, creatinine, beta-2-microglobulin, albumin, and ultrafiltration coefficients (KUF) were measured once during the Pre-ViE phase and twice during the ViE phase. Moreover, biocompatibility markers [leucocyte count, platelet count, and activated complement factor (C3a) levels] were evaluated pre-dialysis, 15 min after initiation, and post-dialysis. During the study, type and number of adverse events (AEs), and device malfunctions were recorded. ViE-21 reduction ratios and KUF were not noticeably different than those of conventional hemodialyzers. Fluctuations of leucocyte counts and C3a concentrations were similar using ViE-21 and conventional hemodialyzers; however, the platelet count fluctuation was lower in ViE-21 sessions. The frequency of episodes of hypotension occurring during the ViE phase was lower than that occurring during the Pre- and Post-ViE phases. In conclusion, this study provided performance and safety data of the ViE-21 for regulatory application. The data suggest that vitamin E-bonded hemodialyzers are beneficial in lowering platelet activation and frequency of intradialytic hypotension. Larger randomized controlled trials are needed to confirm these findings.

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“…All these listed above have been found in small in in vitro or in vivo studies [8][9][10][11][12][13][14][15][16][17].…”

Section: Antiatherosclerotic Effectmentioning

confidence: 94%

“…Other researchers found that gamma-tocopherol is a detoxifier of peroxynitrile radicals. More recent in vitro studies found that vitamin E-coated dialysis membranes reduce intracellular ROS in monocytes and maintain normal activity of Cu/Zn superoxide dismutase [4,[10][11][12].…”

Section: Antioxidant Agentmentioning

confidence: 99%

Vitamin E in Hemodialysis Patients

Rusu¹

2018

Vitamin E in Health and Disease

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End-stage renal disease patients treated with hemodialysis are characterized by a special diet, increased oxidative stress, cardiovascular morbidity and mortality, as well as many other complications such as inflammation-malnutrition syndrome, muscle cramps, and anemia. Worldwide efforts are focused on reducing hemodialysis complications to increase survival in these patients. In vitro and in vivo studies proved that vitamin E has many beneficial effects such as: decreases reactive oxygen species synthesis, improves antioxidant defense system, inhibits lipids peroxidation and reduces atherosclerosis, and ameliorates anemia treatment. Mechanisms of action are complex and not fully understood. However, there are particularities in regards of vitamin E intake, metabolism, and clearance in patients treated with hemodialysis. Supplementation of vitamin E in these patients has been intensively studied, and it is still under debate. Oral administration and vitamin E-coated membranes for dialysis have been tried. Clinical practice guidelines tried to underline when and how much vitamin E to be given to be safe and costbeneficial. The current chapter aims to synthesize all these issues.

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Vitamin E-Coated Dialyzer Inhibits Oxidative Stress

Cited by 12 publications

References 14 publications

Hemodialysis raises oxidative stress through carbon-centered radicals despite improved biocompatibility

Hemodialysis raises oxidative stress through carbon-centered radicals despite improved biocompatibility

Clinical evaluation of performance, biocompatibility, and safety of vitamin E-bonded polysulfone membrane hemodialyzer compared to non-vitamin E-bonded hemodialyzer

Vitamin E in Hemodialysis Patients

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