Vitamin E-coated dialyzer and antioxidant defense parameters: Three-month study

Vitamin E as a Functional and Biocompatibility Modifier of Synthetic Hemodialyzer Membranes: An Overview of the Literature on Vitamin E-Modified Hemodialyzer Membranes

“…Other reports demonstrated the positive effects related to (a) decreased oxidative stress [72,73,74,75,76,77,78,79,80,81]; (b) suppression of leukocyte activation [82,83,84,85,86,87,88]; (c) reduction of anticoagulant dosage [89]; (d) improved biocompatibility [90], and (e) decreased levels of advanced glycation end products [91]. Moreover, a recent study by Kirmizis et al [92] showed lowered levels of the inflammatory markers CRP, IL-6, and soluble intercellular adhesion molecule-1 in 35 patients when treated with Excebrane with respect to baseline treatments carried out with conventional low- or medium-flux dialyzers, while no change was observed in a matched control group of 25 patients who underwent treatment with these later unmodified dialyzers for the whole observation time.…”

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

“…Changes in plasma and RBC glutathione peroxidase (GSH-PX) activities were reported in 3 [11,26,44] and 5 studies [36,44,49,55,58] , respectively. Data on RBC superoxide dismutase (SOD) activity were available in 5 studies [11,26,49,55,58] .…”

“…Changes in plasma and RBC glutathione peroxidase (GSH-PX) activities were reported in 3 [11,26,44] and 5 studies [36,44,49,55,58] , respectively. Data on RBC superoxide dismutase (SOD) activity were available in 5 studies [11,26,49,55,58] . Plasma malondialdehyde (MDA) was measured in 13 studies [11,14,18,25,36,40,41,49,50,54,58,63,71], while 4 studies [36,42,63,71] provided data on RBC MDA.…”

“…Plasma malondialdehyde (MDA) was measured in 13 studies [11,14,18,25,36,40,41,49,50,54,58,63,71], while 4 studies [36,42,63,71] provided data on RBC MDA. Twenty one studies [10, 11, 17, 24, 28, 30-32, 37, 38, 44, 46-49, 51, 54, 57, 58, 63, 71] examined the effect of ViE-m or conventional membranes on blood vitamin E levels, while 5 studies [11,37,42,58,71] 104 vitamin E levels. Six studies [11,16,26,30,49,63] focused on blood vitamin C levels.…”

Review of the Effectiveness of Cellulose- and Polysulfone-Based Vitamin E-Bonded Dialysis Membranes

“…A larger multicenter study (172 patients) reported by Cruz et al, 2008, confirmed that the impact of Excebrane dialyzers on anemia parameters was better than that of other high-flux biocompatible dialyzer membranes, including cellulose acetate, polysulfone, and polymethylmethacrylate. Other reports demonstrated positive effects such as (1) decreased oxidative stress (Tarng et al, 2000;Miyazaki et al, 2000;Clermont et al, 2001;Westhuyzen et al, 2003;Bufano et al, 2004;Mydlik et al, 2004;Calò et al, 2004;Yang et al, 2006;and Odetti et al, 2006), (2) suppression of leukocyte activation (Omata et al, 2000;Zaluska et al, 2001;Pertosa et al, 2002;Tsuruoka et al, 2002;Libetta et al, 2004;and Kojima et al, 2005), (3) dosage reduction of anticoagulants (Huraib et al, 2000), (4) improved biocompatibility (Yoshida et al, 2002), and (5) decreased levels of advanced glycation end products (AGEs) (Baragetti et al, 2006). Moreover, a recent study reported by Kirmizis D et al, 2010, showed that the levels of inflammatory markers such as C-reactive protein (CRP), interleukin (IL)-6, and soluble intercellular adhesion molecule (sICAM)-1 in 35 patients treated with Excebrane were lower than those in the baseline evaluation carried out with conventional low-or middle-flux dialyzers.…”