Vitamin E and stress

Green, J.; Muthy, I. R.; Diplock, A. T.; Bunyan, J.; Cawthorne, Michael A.; Murrell, Elspeth A.

doi:10.1079/bjn19670086

Cited by 23 publications

(18 citation statements)

References 53 publications

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“…The rats were allocated to experimental groups at random with litter-mate control. In the experiment with [Wlretinol, the rats were housed individually in tubular cages to prevent coprophagy (Green, Diplock et al 1967).…”

Section: E X P E R I M E N T a L A N D R E S U L T Smentioning

confidence: 99%

“…Materials. Methyl oleate (OLME) and cod-liver oil methyl esters (CLOME) were prepared free from vitamin E as described by Green, Diplock et al (1967). [14C-carbinollretinyl acetate was obtained from the Radiochemical Centre, Amersham.…”

Section: E X P E R I M E N T a L A N D R E S U L T Smentioning

confidence: 99%

“…In our previous publication (Green, Muthy et al 1967) it was suggested that most of the experiments of earlier workers on the vitamin A-vitamin E relationship con-founded a possible sparing effect in the tissues with the more certain interaction of the two vitamins in the gastro-intestinal tract. Attention was drawn to the contradictory nature of many of the reports, which, we believe, may be explained by differences in the dietary conditions used by various workers, with particular respect to the presence of natural antioxidant substances other than a-tocopherol.…”

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confidence: 99%

“…We have previously described some studies on the relationships between vitamin E, vitamin A and dietary lipid in the chick and the rat and have discussed the problem of the vitamin A-vitamin E relationship in terms of the biological antioxidant hypothesis (Green, Muthy, Diplock, Bunyan, Cawthorne & Murrell, 1967). There is now much evidence that the concept that vitamin E deficiency diseases are caused by the 'proliferation' of lipid peroxidation in vivo is untenable and any role for vitamin E as a physiological antioxidant would now seem difficult to support.…”

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On the relationship between vitamin A and vitamin E in the rat

et al. 1968

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I . The effect of vitamin E on the metabolism, utilization and storage of vitamin A has been studied in the rat.2. Male weanling rats were given a vitamin A-deficient, vitamin E-deficient diet until growth had ceased for 3 days, and each rat was then given 50 i.u. vitamin A palmitate. The rats were divided into four groups and given the diet with the addition of 10 % methyl oleate or 10 yo cod-liver oil methyl esters, or either of these diets supplemented with IOO ppm D-Utocopheryl acetate. There was no increase in maximum weight-gain response in the two groups given vitamin E. There was a significantly lower weight-gain response in the groups given cod-liver oil methyl esters. This effect was not influenced by the presence of vitamin E in the diet.3. Weanling rats of both sexes were made deficient in vitamins A and E and then divided into two groups. One group received, every other day, 1-75 i.u. vitamin A palmitate and 0.6 mg D-a-tocopherol given together; the second group received the two vitamins, in the same amounts, on alternate days. After zS days there was no difference in the growth of the two groups of rats, irrespective of sex.4. Vitamin A-depleted, vitamin E-deficient rats were given 17.5 I ,ug [14C-carbinol]retiny1 acetate and then a vitamin A-deficient, vitamin E-deficient diet or that diet supplemented with IOO ppm D-a-tocopheryl acetate. After 6 days, the total remaining ['*C]retinol and its lipidsoluble metabolites were measured in the carcasses of the rats. Vitamin E administration did not affect the metabolism of the vitamin A dose or its effect on growth.5. Vitamin E-deficient rats were givenvitaminA until their liver reserves exceeded 30000 i.u. and were then divided into two groups. One group received a diet deficient in vitamins A and E and the other received, in addition to this diet, a weekly oral supplement of I mg D-cc-tocopheryl acetate. The vitamin E supplement significantly decreased the rate of vitamin A depletion from the liver during the next 6 weeks. This effect, which was not found to occur when the initial liver reserves were only 3000 i.u., suggests a role for vitamin E in connexion with the capacity of the liver to bind vitamin A. 6. The relationship between vitamin A and vitamin E in vivo cannot, in the light of these results, be regarded as that between an antioxidant and a peroxidizable substrate.

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Section: E X P E R I M E N T a L A N D R E S U L T Smentioning

confidence: 99%

Section: E X P E R I M E N T a L A N D R E S U L T Smentioning

confidence: 99%

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On the relationship between vitamin A and vitamin E in the rat

et al. 1968

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“…Vitamin E has been found to protect against all three deficiency conditions with either fat-free or high fat diets (Hutcheson et al 1963), althoughthere is one rcport that under practical conditions, Se and not vitamin E was effective against encephalomalacia (Gilchrist 197 1 ) . In the rat, the sulfur amino acids are only partially efiective against liver necrosis whereas the protection afforded by Se and vitamin E is not affected by dietary fat (Green et al 1967). Se is effective in preventing NMD in the lamb and calf where the disorder occurs under farm conditions (Proctor et al 1958;Muth et aI.…”

Section: Introductionmentioning

confidence: 99%