Vitamin E and ginseng supplementation to enhance female sexual function: a randomized, double-blind, placebo-controlled, clinical trial

Ghamari, Kiandokht; Kashani, Ladan; Jafarinia, Morteza; Najafabadi, Borna Tadayon; Shokraee, Kamyar; Esalatmanesh, Sophia; Akhondzadeh, Shahin

doi:10.1080/03630242.2020.1803465

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…Supplementation in the elderly with this substance has been shown to reduce the risk of respiratory complications in nursing homes [ 327 ]. Vitamin E also has effects on human reproductive health; an experimental study found that it increased sexual desire and satisfaction when administered together with ginseng in women [ 328 ]. It also has positive interactions in ameliorating certain skin disorders [ 329 ] and in cardiovascular medicine [ 330 ].…”

Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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Glaucoma is a chronic optic neuropathy that can lead to irreversible functional and morphological damage if left untreated. The gold standard therapeutic approaches in managing patients with glaucoma and limiting progression include local drops, laser, and/or surgery, which are all geared at reducing intraocular pressure (IOP). Nutrients, antioxidants, vitamins, organic compounds, and micronutrients have been gaining increasing interest in the past decade as integrative IOP-independent strategies to delay or halt glaucomatous retinal ganglion cell degeneration. In our minireview, we examine the various nutrients and compounds proposed in the current literature for the management of ophthalmology diseases, especially for glaucoma. With respect to each substance considered, this minireview reports the molecular and biological characteristics, neuroprotective activities, antioxidant properties, beneficial mechanisms, and clinical studies published in the past decade in the field of general medicine. This study highlights the potential benefits of these substances in glaucoma and other ophthalmologic pathologies. Nutritional supplementation can thus be useful as integrative IOP-independent strategies in the management of glaucoma and in other ophthalmologic pathologies. Large multicenter clinical trials based on functional and morphologic data collected over long follow-up periods in patients with IOP-independent treatments can pave the way for alternative and/or coadjutant therapeutic options in the management of glaucoma and other ocular pathologies.

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Section: Resultsmentioning

confidence: 99%

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Musa

Zeppieri

Atuanya

et al. 2023

Life

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“…8 Particularly, they have been used in China for over 4500 years to address issues such as aging, healthy life expectancy, and ovarian dysfunction, making them among the most widely used alternative medicines in the world. 9 Ginsenosides are steroidal compounds that are isolated from different parts of ginseng, such as roots, buds, fruits and leaves and can also be obtained through physicochemical or biological treatment. 10 At present, over 100 types of ginsenosides have been identified.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ginsenoside – a promising natural active ingredient with steroidal hormone activity

Li,

Zhao,

Wang

et al. 2024

Food Funct.

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“…Ginseng ( Panax ginseng C. A. Meyer) is a traditional herb, which has been widely used to address aging, healthy life expectancy and ovarian dysfunction ( 7 , 8 ). Ginsenosides is a steroid compound, regarded as the active ingredient with high content in ginseng, which has a variety of pharmacological activities such as relieving body fatigue, enhancing immunity, improving sleep and protecting nerves ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…The steroid hormone most similar to estrogen in Drosophila is 20-Hydroxyecdysone (20E) ( 19 ). It had been reported that 20E binds to its receptor ecdysteroid receptor (ECR) to induce expression of E74 and Broad (Br) transcription factors that regulate female accessory gland development and ovum formation ( 7 , 20 ). Meanwhile, 20E indirectly influences juvenile-preserving hormone (JH) synthesis that controls sexual development, induces sexual priming, and promotes oocyte maturation ( 21 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway

Liu

et al. 2022

Front. Endocrinol.

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Aging ovaries caused diminished fertility and depleted steroid hormone level. Ginsenosides, the active ingredient in ginseng, had estrogen-like hormonal effects. Although ginsenosides were well known for their ability to alleviate many age-related degenerative diseases, the effect of ginsenosides on the decline in reproductive capability caused by aging, as well as the mechanism, are unknown. We found that ginsenosides improved the quantity and quality of the offspring, prolonged life and restored muscle ability in aged female Drosophila. In addition, ginsenosides inhibited ovarian atrophy and maintained steroid hormone 20-Hydroxyecdysone (20E) and juvenile-preserving hormone (JH)) levels. Ginsenosides activated ecdysteroid receptor (ECR) and increased the expression of the early transcription genes E74 and Broad (Br), which triggered steroid signaling pathway. Meanwhile, ginsenosides promoted JH biosynthesis by increasing the expression of Hydroxyl-methylglutaryl-CoA reductase (HMGR) and juvenile hormone acid O-methyltransferase (JHAMT). Subsequently, JH was bound to Methoprene Tolerant (Met) and activated the transcription of the responsive gene Kruppel Homolog 1 (Kr-h1), which coordinated with 20E signaling to promote the reproduction of aged female Drosophila. The reproductive capacity and steroid hormone levels were not improved and the steroid signaling pathway was not activated in ginsenoside-treated ECR knockout Drosophila. This suggested that ginsenosides played a role dependent on targeted ECR. Furthermore, 17 kinds of ginsenoside monomers were identified from the total ginsenosides. Among them, Rg1, Re and Rb1 improved the reproductive capacity and steroid hormone levels of aged female Drosophila, which has similar effects to the total ginsenoside. These results indicated that ginsenosides could enhance the reproductive capacity of aged female Drosophila by activating steroid signals dependent on nuclear receptor ECR. In addition, ginsenoside monomers Rg1, Rb1 and Re are the main active components of total ginsenosides to improve reproductive ability. This will provide strong evidence that ginsenosides had the potential to alleviate age-induced reproductive degradation.

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Vitamin E and ginseng supplementation to enhance female sexual function: a randomized, double-blind, placebo-controlled, clinical trial

Cited by 9 publications

References 34 publications

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

Ginsenoside – a promising natural active ingredient with steroidal hormone activity

Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway

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