Vitamin E and C supplementation does not ameliorate muscle dysfunction after anterior cruciate ligament surgery

Rehabilitation After Anterior Cruciate Ligament Reconstruction

“…Six studies addressed a variety of other issues in rehabilitation after ACL reconstruction (Table VI) [35][36][37][38][39][40] . Barker et al evaluated vitamin-E and vitamin-C supplementation compared with a placebo in a randomized trial of twenty subjects who had undergone ACL reconstruction 35 .…”

“…Barker et al evaluated vitamin-E and vitamin-C supplementation compared with a placebo in a randomized trial of twenty subjects who had undergone ACL reconstruction 35 . Patients received either placebo or vitamin supplementation twice a day.…”

Serum cytokines and muscle strength after anterior cruciate ligament surgery are not modulated by high-doses of vitamins E (α- and γ-tocopherol’s) and C

“…We previously demonstrated that vitamin E and C supplementation was ineffective at modulating cytokines and muscle strength months after ACL surgery [14,40]. In that study, supplemental vitamin E consisted of only aT, which similar to others [27,41], increased plasma aT but decreased cT concentrations [12,40].…”

“…In that study, supplemental vitamin E consisted of only aT, which similar to others [27,41], increased plasma aT but decreased cT concentrations [12,40]. Therefore, it is unknown if increasing cT concomitantly with aT and AA modulates serum cytokines and improves muscle strength after ACL surgery.…”

“…These seminal findings demonstrate the interaction between vitamin C and the different forms of vitamin E that could be influential on maintaining their endogenous levels during inflammation and the subsequent availability of these micronutrients to exert their biological properties. In addition to its interaction with a-and c-T, plasma AA concentrations before surgery correlated with strength recovery after ACL surgery and during inflammation [14,40]. Thus, vitamin C could influence vitamin E levels during inflammation and regulate muscle strength after a ligamentous injury and surgery.…”