Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina

Motoyama, Takeshi; Kawano, Hiroaki; Kugiyama, Kiyotaka; Hirashima, Osamu; Ohgushi, Masamichi; Tsunoda, Ryusuke; Moriyama, Yasushi; Miyao, Yuji; Yoshimura, Michihiro; Ogawa, Hisao; Yasue, Hirofumi

doi:10.1016/s0735-1097(98)00447-1

Cited by 163 publications

(101 citation statements)

References 36 publications

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“…The present study demonstrated that patients with lower levels of flowmediated dilation had a higher probability of developing cardiovascular events as compared with patients with higher levels of flow-mediated dilation. A close correlation of endothelial function in human coronary and brachial arteries has been previously reported (6,7 (14,15).…”

Section: Discussionsupporting

confidence: 68%

“…I n c i d e n c e Ra t e o f Ca r d i o v a s c u l a r E v e n t s previous work as well as in the work of others (6,7). In the present study, we prospectively examined whether flowmediated endothelium-dependent dilation of the brachial artery has prognostic value in the prediction of subsequent cardiovascular events in patients with heart disease.…”

Section: Once Regarded As Merely a Physical Barrier Between The Vesmentioning

confidence: 85%

“…Ka p l a n -Me i e r c u r v e s c o mp a r i n g t h e p r o b a b i l i t y o f d e v e l o p i n g c a r d i o v a s c u l a r e v e n t s i n me n a n d wo me n . (6,(9)(10)(11).…”

Section: Study Patientsunclassified

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Prognostic Value of Flow-Mediated Dilation of the Brachial Artery in Patients with Cardiovascular Disease

et al. 2006

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Section: Discussionsupporting

confidence: 68%

Section: Once Regarded As Merely a Physical Barrier Between The Vesmentioning

confidence: 85%

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Prognostic Value of Flow-Mediated Dilation of the Brachial Artery in Patients with Cardiovascular Disease

et al. 2006

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“…50) In subjects with coronary spasm, vitamin E levels are reduced. 51) Further clinical studies are required to warrant the potential therapeutic benefits of antioxidants in patients with coronary vasospasm.…”

Section: S Saitoh Et Almentioning

confidence: 99%

Mechanistic Insights of Coronary Vasospasm and New Therapeutic Approaches

Saitoh

Takeishi

Maruyama

2015

FJMS

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PREFACECoronary vasospasm is a major health problem in Japan because of its high incidence and severity. Great advances have been made in clinical research and therapy focusing on coronary vasospastic angina. In particular, the Ca antagonist has contributed to improvements in the quality of life of patients with coronary vasospastic angina. Moreover, several animal models of coronary vasospasm have provided insight into the pathophysiology of this disease. However, the mechanisms of coronary vasospasm and microvascular spasm remain elusive. We have studied the mechanisms of coronary vasospasm, including microvascular spasm, in an animal model. The present study was designed to develop an animal model of coronary vasospasm and to elucidate the mechanisms and pathophysiology of coronary vasospasm and new therapeutic approaches. The topics discussed in this article include : (1) the role of endothelial and smooth muscle function on the genesis of coronary vasospasm, (2) the participation of reactive oxygen species in coronary vasospasm, and (3) aging and spasm. We hope that the contents of this volume will be useful to "students of coronary vasospasm" at many levels, including the clinician involved in cardiovascular studies and scientists in various disciplines who are interested in a comprehensive, in -depth review of coronary vasospasm.Coronary vasospasm can be defined as a reversible, focal, and intense coronary vasoconstriction that typically occurs in an epicardial conduit artery segment. The definitive diagnosis of a coronary artery spasm is determined by the direct visualization of such a reversible focal subtotal coronary occlusion at a site distal to the catheter tip. This is generally associated with regional ST segment elevation and angina. The first description of coronary artery spasm was likely made by Heberden in 1802 when he described angina as spasmodic, occurring at rest and related to emotional factors. 1) For over 100 years, this presumed vasoconstrictor phenomenon was implicated in myocardial infarction and angina pectoris. It was not until the mid -twentieth century that the correlation between atherosclerotic plaques and angina pectoris was realized. 2) This observation lessened the interest in vasospasms as an etiology of angina, particularly because later investigations failed to observe spasms very often in patients with angina pectoris. 3) In the latter third of the twentieth century, the demonstration of coronary vasospasm during angina (Prinzmetal's angina) and as a precursor to myocardial infarction 4) resurrected interest in the vasomotor etiology of angina pectoris. 5) In recent years, our understanding of the endothelial modulation of coronary tone has evolved, and substantial insight has been provided from a number of studies over the past three decades. However, the mechanism of coronary vasospasm remains elusive.Some investigations have reported that endothelial dysfunction is present at the site of a coronary vasospasm. 6,7) However, several lines of evidence indicate that coro...

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“…A single, small study in normotensional glaucoma patients has suggested an improvement in visual field damage while on ginkgo (Quaranta, 2003). Vitamin E www.intechopen.com supplements, despite improving vasospastic angina by decreasing oxidative stress, have a still unknown impact on glaucoma (Motoyama, 1998). Nevertheless, the enthusiasm over such therapies must be balanced with the risks of overconsumption because high dosages are known to increase all-cause mortality (Miller, 2005).…”

Section: Systemic Medications and Other Measuresmentioning

confidence: 99%

A Vascular Approach to Glaucoma

Pinto¹,

Stalmans²

2011

Glaucoma - Basic and Clinical Concepts

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Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina

Abstract: The results indicate that vitamin E treatment improved endothelium-dependent vasodilation and decreased plasma TBARS levels in patients with CSA. Thus, increased oxidative stress may contribute to endothelial dysfunction and anginal attacks in patients with CSA.

Cited by 163 publications

References 36 publications

Prognostic Value of Flow-Mediated Dilation of the Brachial Artery in Patients with Cardiovascular Disease

Prognostic Value of Flow-Mediated Dilation of the Brachial Artery in Patients with Cardiovascular Disease

Mechanistic Insights of Coronary Vasospasm and New Therapeutic Approaches

A Vascular Approach to Glaucoma

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