Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury

Xu, Shen; Chen, Yuan-Hua; Tan, Zhu-Xia; Xie, Dongdong; Zhang, Cheng; Xia, Mi-Zhen; Wang, Hua; Zhao, Hui; D, Xu; Yu, Dexin

doi:10.1016/j.jsbmb.2015.05.009

Cited by 84 publications

(65 citation statements)

References 46 publications

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“…Buna göre; 12 hafta sonunda D vitamini alan grupta MCP-1 düzeylerinin anlamlı oranda azaldığı ancak bu düşüşün yılın geri kalanında korunamadığı gösterilmiştir (57). Yapılan diğer bir çalışmada diyaliz tedavisi almayan kronik böbrek hastalarında 25(OH)D düzeyleri düştükçe hs-CRP ve TNF-α düzeylerinin anlamlı oranda arttığı gösterilmiştir (58). Hemodiyaliz ve peritoneal diyaliz tedavisi alan ve serum 25(OH)D düzeyleri 20 ng/mL'den düşük olan son evre böbrek yetmezliği hastaları ile yapılan bir çalışmada, 12 haftalık (50000 IU, haftada 2 defa) 25(OH)D suplemantasyonu sonucunda serum IL-6 ve CRP düzeylerinde anlamlı bir düşüş olduğu gösterilmiştir (59).…”

Section: Karnitinunclassified

“…Vitamin D3'ün farelerde deneysel olarak oluşturulmuş akut böbrek hasarına etkisinin araştırıldığı bir çalışmada, farelere oral olarak verilen vitamin D3'ün 25(OH)D konsantrasyonunu anlamlı şekilde artırdığı ve renal VDR sinyalizasyonunu anlamlı oranda aktive ettiği belirtilmiştir. Vitamin D3 uygulamasının oksidan ve antioksidan enzimlerin genlerinin regüle ederek tübüler epitel hücre apoptozunu hafiflettiği ve böylece renal oksidatif stresi azaltabildiği de gösterilmiştir (58).…”

Section: Karnitinunclassified

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Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Öztürk¹,

Nergiz-Unal²

2018

Turk Neph Dial Transpl

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ÖZKronik böbrek hastalığı, glomerüler filtrasyonun azalmasıyla böbrekte sıvı-solüt dengesinin düzenlen-mesi ve metabolik-endokrin fonksiyonlarda kronik ve ilerleyici bozulma hali olarak tanımlanabilir. Kronik böbrek hastalığı gelişiminde rol alan inflamasyon, kronik böbrek hastalığının sonucu olarak da ortaya çıkabilmekte ve KBH varlığına bağlı mortalite artışının en önemli nedenlerinden biri olarak kabul edilmektedir. İnflamasyon ve diyet etkileşimi ile ilgili yapılan güncel araştırmalar çoklu doymamış yağ asitleri, D vitamini, E vitamini gibi besin ögeleri ile karnitin, lipoik asit, flavanoidler, probiyotikler ve prebiyotikler gibi diğer diyet bileşenlerinin renal inflamasyon sürecindeki olumlu etkilerine işaret etmektedir. Derlemede, olası anti-inflamatuvar bazı diyet bileşenlerinin kronik böbrek hastalığı ile ilişkili inflamasyon üzerine etkileri incelenmiştir. ANAHTAR SÖZCÜKLER: Kronik böbrek hastalığı, Beslenme, İnflamasyon, Diyet ABSTRACTChronic kidney disease can be defined as chronic and progressive deterioration of the regulation of fluid-solute balance and metabolic-endocrine functions of the kidney due to diminishing glomerular filtration. Inflammation in renal disease can develop as a cause or an outcome, and it has been reported in recent studies that inflammation is among the most important causes of disease-related mortality. Investigations on inflammation and diet interactions have shown that the effects of nutrients such as polyunsaturated fatty acids, vitamin D, vitamin E and other dietary components such as carnitine, lipoic acid, flavanoids, probiotics and prebiotics may have positive effects on the renal inflammation process. In this review, the potential anti-inflammatory effects of some current dietary components in chronic kidney disease were studied.

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Section: Karnitinunclassified

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Öztürk¹,

Nergiz-Unal²

2018

Turk Neph Dial Transpl

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“…Peroxynitrite is formed by the reaction between nitric oxide and superoxide anions ) and promotes endothelial dysfunction, vascular hyporeactivity, primary myocardial disease (Szabó 1996) and inactivation of mitochondrial electron transport, damaging cellular respiration (Radi et al 1994). The immunostaining of weak intensity observed in the lungs, liver and kidneys of the horses from the NOLG were considered as control because mild oxidative stress occurs in these organs in healthy animals (Haddad et al1994, Ottesen et al2001, Xu et al 2015, and only strong staining are associated with lesions and inflammatory diseases in lungs (Haddad et al 1994), in hepatic parenchyma (Ottesen et al 2001), in tubular epithelial cells in medulla and in the cortex zone in experimental endotoxemia in rats (Xu et al 2015). However, in the heart and nervous system, no immunostaining for nitrotyrosine is observed in healthy animals (Bodega et al 2006, Szabó et al 2012.…”

Section: Immunostaining For Sodmentioning

confidence: 99%

“…Therefore, immunostaining for nitrotyrosine can be observed in tissues without lesion, such as the liver (Ottesen et al 2001), kidney (Kong et al 2012, Xu et al 2015 and lungs (Haddad et al 1994) of healthy humans or animals. The organs such as heart and nervous system do not show the presence of nitrotyrosine in healthy animals (Tanaka et al 1997, Bodega et al 2006, Szabó et al 2012.…”

Section: Introductionmentioning

confidence: 99%

Laminar lesions in horses with systemic oxidative stress, committed by experimentally induced or naturally occurring gastrointestinal disorders

et al. 2016

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Laminitis in horses can be associated with lesions in multiple organs secondary to sepsis. Twenty-one horses suffering from gastrointestinal disorders were used in the experiment; 7 horses with experimentally induced endotoxemia and intestinal ischaemia, and 14 horses suffering from naturally occurring colic syndrome. Tissue samples of lungs, liver, heart, brain, cerebellum and hoof laminar tissue were collected for histopathological and oxidative stress evaluation using nitrotyrosine and superoxide dismutase (SOD2) immunostaining. The horses were divided into two groups: the non-oxidative lesions group (NOLG), with 7 horses showing weak immunostaining in lungs, liver and kidney, and the oxidative lesions group (OLG), with 14 horses showing immunostaining indicating systemic oxidative stress in multiple organs. The horses from OLG showed increase of laminar lesions and SOD2 immunostaining in multiple organs when compared to the horses from the NOLG. No differences were found ln regard to laminar immunostaining by nitrotyrosine and SOD2 between experimental groups. It was concluded that systemic oxidative stress can be associated with the development of laminar lesions, and that the laminar tissue does not respond to oxidative stress with increase of SOD as occurs in other organs.

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“…In the context of sepsis, it is likely that antioxidizing agents provide some protection but are insufficient to prevent ROS-and RNS-induced damage. [1][2][3][4][5][6][7][8][9] During CKD, an increase in ROS and RNS levels leads to a deficiency of arylesterase/paraoxonase, greater plasma concentrations of thiobarbituric acid-reactive species (TBARS) and activation of polymorphonuclear cells. The latter cells are capable of inducing even greater production of ROS and RNS.…”

Section: Introductionmentioning

confidence: 99%

A review of the impact of oxidative stress and some antioxidant therapies on renal damage

et al. 2015

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An increase in the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) leads to complications during chronic kidney disease (CKD). This increase essentially derives from the impairment of natural antioxidant systems of the organism. The resulting oxidative stress produces damage to kidney tissue, especially by affecting nephrons and more generally by disrupting the function and structure of the glomerulus and interstitial tubule. This leads to a rapid decline in the condition of the patient and finally renal failure. Possible causes of kidney tissue damage are explored, as are different therapies, especially those related to the administration of antioxidants.ARTICLE HISTORY

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Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury

Cited by 84 publications

References 46 publications

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Laminar lesions in horses with systemic oxidative stress, committed by experimentally induced or naturally occurring gastrointestinal disorders

A review of the impact of oxidative stress and some antioxidant therapies on renal damage

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