Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells

Bakdash, Ghaith; Capel, Toni M.M. van; Mason, Lauren M.K.; Kapsenberg, Martien L.; Jong, Esther C. de

doi:10.1016/j.vaccine.2014.08.075

Cited by 54 publications

(43 citation statements)

References 42 publications

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“…43,44 The severe inflammation observed in Vdr/IL-10 double knockout mice is attributed to an augmented pro-inflammatory T cell response. 38 VDR signaling in T cells influences differentiation.…”

Section: Vitamin D/vdr Regulates Immunitymentioning

confidence: 99%

Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation

Bakke

Sun

2018

Inflammatory Bowel Diseases

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Nuclear receptor vitamin D receptor (VDR) regulates most of the biological actions of the active vitamin D metabolite, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3). VDR is highly expressed in intestine and is a critical regulator of proliferation and differentiation, intestinal barrier function, innate immunity, and host defense in the gut. Evidence strongly supports a protective effect of vitamin D and VDR in inflammatory bowel diseases (IBD). Emerging evidence demonstrates low VDR expression and dysfunction of vitamin D/VDR signaling in patients with IBD. In the current review, we summarize recent progress made in vitamin D/VDR signaling in genetic regulation, immunity, and microbiome in both ulcerative colitis and Crohn’s disease. We cover the mechanisms of intestinal VDR in regulating inflammation through inhibiting the NF-κB pathway and activating autophagy. Recent studies suggest that the association of VDR SNPs with immune and intestinal pathology may be gender-dependent. We emphasize the tissue specificity of VDR and its gender and time-dependent effects. Furthermore, we discuss potential clinical application and future direction of vitamin D/VDR in prevention and treatment of IBD.

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Section: Vitamin D/vdr Regulates Immunitymentioning

confidence: 99%

Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation

Bakke

Sun

2018

Inflammatory Bowel Diseases

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“…The considerable host of actions performed by PPARG can be compared to those of vitamin D and VDR [15], which has been implicated in neurologic disorders [16–18], autoimmune pathologies [19–21], cardiovascular disease [22], diabetes mellitus [23, 24], psoriasis [15] or infectious disease [25, 26], and, above all of what is mentioned, cancer [27, 28]. …”

Section: The Pparg Physiologymentioning

confidence: 99%

Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis

2016

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The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation. Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer. This review paper, at crossroads of basic sciences, preclinical, and clinical data, intends to analyse the last research concerning PPARG signalling in obesity and cancer. Afterwards, possible links between four interrelated actors will be established: PPARG, the vitamin D/VDR system, obesity, and cancer, opening up the door to further investigation and new hypothesis in this fascinating area of research.

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“…Almost all cells of the adaptive immune system express the vitamin D receptor, making them also capable of being vitamin D responsive [35]. When specifically considering a potential role for vitamin D in food allergy, vitamin D has been shown to affect several mechanisms that promote immunologic tolerance, including T regulatory cell function [36] and the induction of tolergenic dendritic cells [37,38]. Recently, investigators reported that VDD in pregnant women impairs T regulatory cell function, which could have important implications for allergy predisposition/development in neonates [39].…”

Section: Vitamin D and The Immune Systemmentioning

confidence: 99%