Vitamin D3 and Beta-carotene Deficiency is Associated with Risk of Esophageal Squamous Cell Carcinoma - Results of a Case-control Study in China

Huang, Guiling; Yang, Lei; Su, Ming; Wang, Shaokang; Yin, Hong; Wang, Jiasheng; Sun, Guiju

doi:10.7314/apjcp.2014.15.2.819

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…As shown in Table 1, we did not find significant association of ESCC cases with alcohol consumption and smoking status in the current study, which is consistent with many previously published studies in China, including studies for liver cancer, as well as studies conducted in the same area for esophageal cancer [5, 40, 62, 63]. The major reasons for lack of such association are the prevalence of alcohol drinking (nearly 100% in the study participants) and the nature of the matched case-control design.…”

Section: Discussionsupporting

confidence: 92%

“…Based on the results, high level exposure to AFB 1 and FB 1 were associated with increased risk to ESCC, and greater-than-additive interaction exists between high AFB 1 and FB 1 exposure. The overall dietary patterns and staple food have not been changed for decades in the study area and populations [5, 19, 40], despite of possible periodic variations; therefore, measurement for biomarker levels are reflective of both the current and past exposures, which might be even higher than the currently measured exposure levels.…”

Section: Discussionmentioning

confidence: 99%

“…After signed written consent, a face-to-face interview was conducted, and a total of 190 cases and 380 controls were recruited. Questionnaire on demographics [5, 40], disease history and dietary pattern, blood sample (5 mL), and the morning urine sample (50 mL) were collected. Personnel conducting laboratory analyses were blinded to case and control status.…”

Section: Methodsmentioning

confidence: 99%

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Mycotoxin exposure is associated with increased risk of esophageal squamous cell carcinoma in Huaian area, China

et al. 2019

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BackgroundConsumption of moldy food has previously been identified as a risk factor for esophageal squamous cell carcinoma (ESCC) in high-risk countries; however, what contributing roles these dietary carcinogenic mycotoxins play in the etiology of ESCC are largely unknown.MethodsA mycotoxin biomarker-incorporated, population-based case-control study was performed in Huaian area, Jiangsu Province, one of the two high-risk areas in China. Exposure biomarkers of aflatoxins (AF) and fumonisins (FN) were quantitatively analyzed using HPLC-fluorescence techniques.ResultsAmong the cases (n = 190), the median levels of AF biomarker, serum AFB1-lysine adduct, and FN biomarker, urinary FB1, were 1.77 pg/mg albumin and 176.13 pg/mg creatinine, respectively. Among the controls (n = 380), the median levels of AFB1-lysine adduct and urinary FB1 were 1.49 pg/mg albumin and 56.92 pg/mg creatinine, respectively. These mycotoxin exposure biomarker levels were significantly higher in cases as compared to controls (p < 0.05 and 0.01, respectively). An increased risk to ESCC was associated with exposure to both AFB1 and FB1 (p < 0.001 for both).ConclusionsMycotoxin exposure, especially to AFB1 and FB1, was associated with the risk of ESCC, and a greater-than-additive interaction between co-exposures to these two mycotoxins may contribute to the increased risk of ESCC in Huaian area, China.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Mycotoxin exposure is associated with increased risk of esophageal squamous cell carcinoma in Huaian area, China

et al. 2019

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“…However, the primary risk factor that increases the risk of ESCC/EPL in one population may not be significantly associated with this cancer in another. As reported in previous studies, alcohol use and tobacco smoking, which are the established risk factors for ESCC in other areas, play only a minor role in Huai'an District, whereas the factors such as low consumption of fruits and vegetables, frequent consumption of high-temperature food or beverages, high dietary exposure to nitrite, deficiency of certain nutrients, genetic polymorphism, as well as the exposure to mycotoxins including AFB 1 , have been found to play important roles in the process of carcinogenesis of ESCC in this region [5,19,20,28,[34][35][36][37][38][39]. Further studies will be needed to confirm these findings, explore other potential factors and evaluate the possible interaction among the established factors on ESCC development in the studied population in Huai'an District so that the prevention strategies for ESCC/EPL can be improved.…”

Section: Discussionmentioning

confidence: 97%

Corn Flour Intake, Aflatoxin B1 Exposure, and Risk of Esophageal Precancerous Lesions in a High-Risk Area of Huai’an, China: A Case-Control Study

Wang

Pan

Zhang

et al. 2020

Toxins

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Aflatoxin B1 (AFB1), which has potent toxicity and carcinogenicity, is a common contaminant of important agricultural commodities. This study aimed to investigate the frequency of corn flour intake and assess the exposure to AFB1 via direct detection of AFB1 in the diet and serum AFB1 exposure biomarker, so as to evaluate their associations with the risk of esophageal precancerous lesions (EPL). A case-control study based on three-day duplicate diet samples was performed in Huai’an District. One hundred EPL cases and 100 healthy controls were enrolled and required to be age- (±2 years) and gender-matched. The concentration of AFB1 in food samples and the level of serum AFB1-albumin (AFB1-Alb) adduct were quantitatively analyzed. Results showed that corn flour intake was positively associated with serum AFB1-Alb adduct level (p for trend = 0.003), dietary AFB1 exposure (p for trend < 0.001), and the risk of EPL (p for trend = 0.017). Increased serum AFB1-Alb adduct level was associated with an increased risk of EPL as well (p for trend < 0.001). In conclusion, corn flour may be an essential source of AFB1 in Huai’an District, whereas high exposure to AFB1 is likely to be an important risk factor contributing to the progression of EPL.

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“…Briefly, 200 ul skin homogenate solution was added into 1 mL methanol with vortex for 30s. And then 1 mL of hexane was added to extract VD 3 under oscillation mixture for 2 min [18]. The mixture was centrifuged at 2000 rpm for 5 min to separate supernatant fluid.…”

Section: Methodsmentioning

confidence: 99%

Liposomal Vitamin D3 as an Anti-aging Agent for the Skin

Xia

et al. 2019

Pharmaceutics

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Vitamin D3 is an effective skin protective substance to prevent photoaging. Liposomes were used as a carrier to deliver vitamin D3 to improve the stability and to enhance the treatment effect of vitamin D3. The stability of vitamin D3 liposomes, average cumulative penetration, and retention of vitamin D3 in the skin were then evaluated and compared with free vitamin D3. Finally, the treatment effect of vitamin D3 liposomes in a rat photoaging model was appraised and Haematoxylin-Eosin (H&E) staining was used to assess the histology changes of the skin after vitamin D3 liposome treatment. The results indicated that liposomes could significantly improve the stability of vitamin D3. The average skin retention of vitamin D3 liposomes was 1.65 times that of the vitamin D3 solution. Vitamin D3 liposomes could repair the surface morphology of skin in the photoaging model and promote the production of new collagen fibers. Vitamin D3 liposomes as a potential skin care agent could significantly improve skin appearance and repair damage in the histology of photoaging.

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Vitamin D3 and Beta-carotene Deficiency is Associated with Risk of Esophageal Squamous Cell Carcinoma - Results of a Case-control Study in China

Cited by 9 publications

References 22 publications

Mycotoxin exposure is associated with increased risk of esophageal squamous cell carcinoma in Huaian area, China

Mycotoxin exposure is associated with increased risk of esophageal squamous cell carcinoma in Huaian area, China

Corn Flour Intake, Aflatoxin B1 Exposure, and Risk of Esophageal Precancerous Lesions in a High-Risk Area of Huai’an, China: A Case-Control Study

Liposomal Vitamin D3 as an Anti-aging Agent for the Skin

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