2010
DOI: 10.1159/000315119
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Vitamin D, Ultraviolet Exposure, and Skin Cancer in the Elderly

Abstract: Ultraviolet (UV) radiation has both beneficial and harmful effects on the human body. Its most important beneficial effect may be vitamin D production in the skin, also known as vitamin D photosynthesis. This is of particular interest for the elderly who often show vitamin D-deficiency. Intentional UV exposure has been recommended by different institutions in order to increase vitamin D levels. Nevertheless, UV radiation directly causes DNA damage and is verifiably responsible for carcinogenesis, potentially r… Show more

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Cited by 25 publications
(24 citation statements)
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“…[2] Vitamin D has many noncalcemic functions, which includes immune, cardiovascular, endocrine, neuropsychological functions, neuromuscular performance, cellular differentiation, and anticancer actions. [34567]…”
Section: Introductionmentioning
confidence: 99%
“…[2] Vitamin D has many noncalcemic functions, which includes immune, cardiovascular, endocrine, neuropsychological functions, neuromuscular performance, cellular differentiation, and anticancer actions. [34567]…”
Section: Introductionmentioning
confidence: 99%
“…To be fully activated, however, vitamin D needs to undergo two hydroxylation reactions in the liver and kidney to form 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH) 2 D), respectively (4) . Apart from calcaemic actions, vitamin D has many non-calcaemic functions, among which are immune function (5) , cellular differentiation (6) and anticancer actions (7)(8)(9)(10)(11) . Vitamin D insufficiency in the long term may not only lead to metabolic bone disorders such as osteomalacia and osteoporosis but may also have a role in the development of many chronic diseases such as autoimmune disorders (12) (e.g.…”
mentioning
confidence: 99%
“…[51][52][53] The IOM recommendation of 600 IU of vitamin D daily to anyone above the age of 1 and 800 IU to those greater than age 70, while aiming for a level Ն20 ng/ ml, appears reasonable. 1 As physicians and health care providers, however, we must be aware that population guidelines may not be adequate for every individual and must use our best judgment for each of our patients.…”
Section: Final Recommendationsmentioning
confidence: 99%