Vitamin D Treatment for the Prevention of Falls in Older Adults: Systematic Review and Meta‐Analysis

Kalyani, Rita R.; Stein, Brady L.; Valiyil, Ritu; Manno, Rebecca L.; Maynard, Janet W.; Crews, Deidra C.

doi:10.1111/j.1532-5415.2010.02949.x

Cited by 204 publications

(136 citation statements)

References 50 publications

(261 reference statements)

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“…Eight meta-analyses [17][18][19][20][21][22][23][24] of vitamin D levels and falls have been conducted, some with conflicting results. Online Table A provides an overview of these meta-analyses, including populations, outcomes and other methodological issues.…”

Section: Systematic Review/meta-analysismentioning

confidence: 99%

Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs

Allan

Cranston²,

Lindblad

et al. 2016

J GEN INTERN MED

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Over the past decade, a large body of observational evidence has suggested an association between lower vitamin D status (25-hydroxyvitamin D) and multiple acute and chronic disorders, including cancer, multiple sclerosis, depression and respiratory tract infections. This evidence has fostered the hypothesis that increasing vitamin D intake may treat and prevent such disorders. Our objective was to perform a critical analysis of the highestlevel evidence for ten common beliefs regarding vitamin D for the prevention of falls, fractures and respiratory tract infections, the reduction of cancer incidence/mortality and overall mortality, and the prevention or treatment of depression/mental well-being, rheumatoid arthritis and multiple sclerosis, as well as maximum dosing and regular testing. We searched the Cochrane Database of Systematic Reviews and PubMed (up to August 2014) for randomized controlled trials and systematic reviews/ meta-analyses based on those studies. All searches were performed, all evidence reviewed and each section written by at least two authors. The evidence shows that vitamin D supplementation provides some benefit in fracture prevention (likely ∼10-15 % relative reduction), particularly at a dose ≥800 IU and with calcium; a likely benefit in the rate of falls, though it is less clear whether the number of fallers changes; and a possible small (∼5 %) relative reduction in mortality. Evidence does not support the use of vitamin D supplementation for the prevention of cancer, respiratory infections or rheumatoid arthritis. Similarly, evidence does not support vitamin D supplementation for the treatment of multiple sclerosis and rheumatoid arthritis or for improving depression/mental well-being. Regular testing of 25-hydroxyvitamin D is generally not required, and mega-doses (≥300,000 IU) appear to increase harms. Much of the evidence is at high risk of bias, with multiple flaws, including analyses of secondary endpoints, small and underpowered studies, inconsistent results and numerous other issues. Therefore, enthusiasm for a vitamin D panacea should be tempered.

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Section: Systematic Review/meta-analysismentioning

confidence: 99%

Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs

Allan

Cranston²,

Lindblad

et al. 2016

J GEN INTERN MED

View full text Add to dashboard Cite

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“…A serum concentration of 25 OH vitamin D of at least 20 ng/mL is required to maintain parathyroid hormone (PTH) within the normal range and this hormone is required for bone and muscle functioning and to prevent osteomalacia (13). Vitamin D insufficiency can result in secondary hyperparathyroidism, increased bone resorption and increased low-energy trauma fracture (14). In secondary hyperparathyroidism, serum calcium levels are maintained by the resorption of calcium from bone and increased phosphorus loss in the kidneys (15).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Vitamin D Deficiency in Nonspecific Musculoskeletal Pain

2015

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Background: Vitamin D deficiency is common in all age groups throughout the world, and results in abnormalities in calcium, phosphorous and bone metabolism that can lead to muscle weakness, osteomalacia and osteopenia. Objectives: This study was designed to investigate the prevalence of vitamin D deficiency in patients with nonspecific pain for whom no specific causes such as trauma, infection, tumor, and inflammatory disorders could be identified. Patients and Methods:This cross-sectional study included 438 patients with nonspecific musculoskeletal pain seen at our clinic. After evaluating their vitamin D status, we treated two groups of patients: those with vitamin D deficiency (< 20 ng/mL) and those with insufficiency (20 -29 ng/mL). We treated our patients with 50,000 units of vitamin D every week for 6 -8 weeks. After treatment we evaluated pain relief of patient and level of 25 hydroxi vitamin D. Results: A total of 438 patients (52 men and 386 women) participated in the study. There was no statistically significant correlation between sex and symptoms. Deficiency was more frequent in females but the difference compared to males was not statistically significant. Approximately half of the patients (47%) comprised the vitamin D-deficient group. Most patients (86.5%) had insufficient or deficient levels (< 30 ng/mL) of vitamin D. The most prevalent vitamin D status in men was insufficiency, whereas the most prevalent status in women was deficiency. Spearman's correlation coefficient showed weak positive correlations between vitamin D status and the number of pregnancies (r = 0.14). More than 90% of our patients reported that pain and muscle weakness responded to treatment after 3 weeks. Conclusions: Because osteomalacia is a common cause of persistent, nonspecific musculoskeletal pain, screening all patients with these symptoms for hypovitaminosis D should be standard practice in clinical care.

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“…D vitamini kalsiyum homeostazında kritik öneme sahiptir. D vitamininin düşme riskini ve kırık oluşumunu azalttığı, postmenopozal osteoporozu önlediği ve osteoporoz tedavisinde yer alması gerektiği çeşitli çalışmalarda gösterilmiştir (5,6). Birçok çalışmada D vitamini eksikliğinin kardiyovasküler risk faktörlerini, kanser sıklığını, multipl skleroz, metabolik, enfeksiyöz ve otoimmün hastalıkları arttırdığı belirtilmektedir (7,8).…”

Section: Introductionunclassified

Evaluation of Serum 25-Hydroxy Vitamin D Levels in Premenapousal Psoriasis Patients

Vural¹,

Topkarcı²,

Ersoy³

et al. 2014

Tod

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SummaryObjective: To investigate the serum 25-hydroxy vitamin D levels in systemic treatment planned premenopausal psoriasis patients and compare it with the same age and sex matched healthy volunteers. Materials and Methods: Forty-one psoriasis patients and 57 healthy controls (total of 98) were included in the study. Serum 25-hydroxy vitamin D levels were compared between the two groups; also the relationship of disease activity and 25-hydroxy Vitamin D levels were examined in patients with psoriasis. Probability values of <0.05 were considered as statistically significant. Results: The mean age of patients with psoriasis and control groups were not statistically different (p>0.05). In addition, the mean 25-hydroxy vitamin D levels were not significantly different among the two groups (p>0.05). 25-hydroxy vitamin D levels were no significantly different in patients with and without psoriatic arthritis (p>0.05). No significant correlation was found between psoriasis area severity index PASI values, age or 25-hydroxy vitamin D levels (p>0.05). Conclusion:The low levels of vitamin D in population is reported to be common. In our study, similar low vitamin D levels were found in healthy volunteers and premenopausal psoriasis patients. Serum 25-hydroxy vitamin D levels were not correlated with disease activity in patients with psoriasis. Correlation between psoriasis, disease activity and vitamin D levels should be investigated in larger populations.

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Vitamin D Treatment for the Prevention of Falls in Older Adults: Systematic Review and Meta‐Analysis

Cited by 204 publications

References 50 publications

Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs

Vitamin D: A Narrative Review Examining the Evidence for Ten Beliefs

Prevalence of Vitamin D Deficiency in Nonspecific Musculoskeletal Pain

Evaluation of Serum 25-Hydroxy Vitamin D Levels in Premenapousal Psoriasis Patients

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