Vitamin D supplementation trial in infancy: body composition effects at 3 years of age in a prospective follow‐up study from Montréal

Hazell, Tom J.; Gallo, Sina; Vanstone, Catherine A.; Agellon, Sherry; Rodd, Celia; Weiler, Hope A.

doi:10.1111/ijpo.12105

Cited by 30 publications

(31 citation statements)

References 30 publications

(40 reference statements)

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“…In 1 trial low birthweight (1.8–2.5 kg) Indian infants randomized to receive weekly vitamin D from birth had increased length, weight, and arm circumference at 6 months of age as compared to infants who received placebo ( 27 ). In addition, an observational study of Canadian infants found higher vitamin D concentrations during infancy to 3 years of age were associated with leaner body composition ( 28 ). Studies evaluating the association of child 25(OH)D status with body composition are warranted in LMICs given rapidly increasing rates of pediatric obesity and noncommunicable diseases in adulthood ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency Is Not Associated With Growth or the Incidence of Common Morbidities Among Tanzanian Infants

Sudfeld¹,

Manji²,

Smith

et al. 2017

J. pediatr. gastroenterol. nutr.

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Objective:The objective of this study was to examine risk factors for vitamin D deficiency and determine the association of vitamin D status with child growth and incidence of common morbidities among Tanzanian infants.Methods:A prospective cohort of 581 Tanzanian infants born to human immunodeficiency virus (HIV)-uninfected mothers had serum 25-hydroxyvitamin D assessed at 6 weeks and 6 months of age. Infants were seen at monthly clinic visits for growth monitoring until 18 months of age. Physicians examined infants every 3 months or when an illness was noted to document morbidities.Results:The prevalence of vitamin D deficiency (<20 ng/mL) declined from 76.4% at 6 weeks of age to 21.2% at 6 months. Infants who were exclusively breastfed at 6 weeks of age had 2.05 (95% confidence interval 1.11–3.79; P = 0.02) times the risk of vitamin D deficiency as compared formula-fed infants. After multivariate adjustment, there was no association of vitamin D status at 6 weeks or 6 months with the incidence of stunting, wasting, or underweight. There was also no association of low vitamin D with the incidence of diarrhea, upper respiratory infection, acute lower respiratory tract infection, or malaria.Conclusions:Vitamin D deficiency is common during early infancy, particularly among exclusively breastfed infants; however, these observational data suggest it may not be an important contributor to morbidity and growth among the general population of Tanzanian infants. Future studies of vitamin D among high-risk infants, including those with low birthweight and exposed to HIV, may be warranted.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency Is Not Associated With Growth or the Incidence of Common Morbidities Among Tanzanian Infants

Sudfeld¹,

Manji²,

Smith

et al. 2017

J. pediatr. gastroenterol. nutr.

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“…[ 30 ] In addition, an observational study of Canadian infants found higher vitamin - D concentrations during infancy to 3 years of age were associated with leaner body composition. [ 31 ]…”

Section: Discussionmentioning

confidence: 99%

Vitamin-D status and neurodevelopment and growth in young north Indian children: a secondary data analysis

Chowdhury

Taneja

Bhandari

et al. 2017

Nutr J

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BackgroundVitamin-D deficiency has been linked with impaired development in animal studies; however, the evidence from human studies is scanty. Evidence as to whether vitamin-D deficiency during early childhood affects growth is also limited and conflicting. We examined the extent to which vitamin-D deficiency (<10 ng/ml) is associated with neurodevelopment and physical growth in young children.MethodsWe used data from a randomized controlled trial (RCT) of daily folic acid and/ or vitamin B12 supplementation for six months in children aged 6 to 30 months conducted in Delhi, India. We measured vitamin-D status and neurodevelopment by the Ages and Stages Questionnaire-3 (ASQ-3) at 12 to 36 months of age. Multiple logistic and linear regressions were used to examine the association between vitamin-D deficiency at baseline and neurodevelopment and growth 6 months follow-up.Results25-hydroxy-vitamin-D (25OHD) concentration was measured at baseline for 960 (96%) children. Of these, 331 (34.5%) children were vitamin-D deficient. The total and subscale (except for the Personal social scale) ASQ-3 scores, were not different between the vitamin-D deficient and non-deficient children. Vitamin-D deficiency was also not associated with physical growth at baseline and at follow -up.ConclusionOur data do not support the hypothesis that vitamin-D deficiency is associated with poor growth and neurodevelopment.Trial registration NCT00717730 and CTRI/2010/091/001090. Date of registration: 08 October, 2010

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“…Some human studies showed that low maternal 25(OH)‐vitamin D [25(OH)D] status was associated with increased odds of overweight at the first year , greater fat mass at ages 4 and 6 years and higher fat percentage at 9.5 years . Additionally, a VitD supplementation trial showed that higher VitD concentrations over the first 3 years of life were associated with a leaner body composition in offspring . However, a large prospective pregnancy cohort study , and two other smaller birth cohort studies , showed no association of maternal VitD status with child cardiometabolic risk.…”

Section: Introductionmentioning

confidence: 99%

Low maternal vitamin D status in pregnancy increases the risk of childhood obesity

et al. 2018

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Vitamin D supplementation trial in infancy: body composition effects at 3 years of age in a prospective follow‐up study from Montréal

Abstract: Higher vitamin D status from infancy through to 3 years of age associates with leaner body composition.

Cited by 30 publications

References 30 publications

Vitamin D Deficiency Is Not Associated With Growth or the Incidence of Common Morbidities Among Tanzanian Infants

Vitamin D Deficiency Is Not Associated With Growth or the Incidence of Common Morbidities Among Tanzanian Infants

Vitamin-D status and neurodevelopment and growth in young north Indian children: a secondary data analysis

Low maternal vitamin D status in pregnancy increases the risk of childhood obesity

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