Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape

Ren, Lulu; Xuan, Lingling; Han, Feifei; Zhang, Jie; Gong, Lili; Lv, Yali; Zhang, Wen; Yang, Song; Xu, Benshan; Yan, Yan; Guo, Lei; Liu, He; Wan, Zhenzhen

doi:10.1016/j.taap.2020.115076

Cited by 14 publications

(7 citation statements)

References 53 publications

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“…Optic atrophy 1 is a marker of fusion of the inner membrane on mitochondria, which results in larger mitochondria and increased oxidative capacity (Kushnareva et al, 2013). In contrast, an increase in OPA1 expression was observed after vitamin D supplementation in vitamin D deficient mice with statin-induced myopathy (Ren et al, 2020), as well as in human skeletal muscle cells treated with 1,25(OH)D (Ryan et al, 2016). While these studies all suggest that 1,25(OH) D treatment or VDR expression alter OPA1, it is unclear why both VDR knockdown and 1,25(OH)D treatment led to increased OPA1 expression.…”

Section: Vitamin D and Mitochondrial Healthmentioning

confidence: 99%

Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health

et al. 2021

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Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. Furthermore, mounting evidence suggests that vitamin D may play an important role during muscle damage and regeneration. Muscle damage is characterized by compromised muscle fiber architecture, disruption of contractile protein integrity, and mitochondrial dysfunction. Muscle regeneration is a complex process that involves restoration of mitochondrial function and activation of satellite cells (SC), the resident skeletal muscle stem cells. VDR expression is strongly upregulated following injury, particularly in central nuclei and SCs in animal models of muscle injury. Mechanistic studies provide some insight into the possible role of vitamin D activity in injured muscle. In vitro and in vivo rodent studies show that vitamin D mitigates reactive oxygen species (ROS) production, augments antioxidant capacity, and prevents oxidative stress, a common antagonist in muscle damage. Additionally, VDR knockdown results in decreased mitochondrial oxidative capacity and ATP production, suggesting that vitamin D is crucial for mitochondrial oxidative phosphorylation capacity; an important driver of muscle regeneration. Vitamin D regulation of mitochondrial health may also have implications for SC activity and self-renewal capacity, which could further affect muscle regeneration. However, the optimal timing, form and dose of vitamin D, as well as the mechanism by which vitamin D contributes to maintenance and restoration of muscle strength following injury, have not been determined. More research is needed to determine mechanistic action of 1,25(OH)D on mitochondria and SCs, as well as how this action manifests following muscle injury in vivo. Moreover, standardization in vitamin D sufficiency cut-points, time-course study of the efficacy of vitamin D administration, and comparison of multiple analogs of vitamin D are necessary to elucidate the potential of vitamin D as a significant contributor to muscle regeneration following injury. Here we will review the contribution of vitamin D to skeletal muscle regeneration following injury.

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Section: Vitamin D and Mitochondrial Healthmentioning

confidence: 99%

Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health

et al. 2021

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“…Each mouse made three trials on each test day with a 30-min interval between trials, and the gauge was reset to 0 g between trials. The mean values (g) were calculated and normalized to body weight using the following formula: Normalized strength = (Force/body weight for each mouse) (Han et al, 2020 ; Ren et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis

Al-Otaibi

Alghamdi²,

Alghamdi³

et al. 2023

Front. Behav. Neurosci.

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Stimulation of remyelination is critical for the treatment of multiple sclerosis (MS) to alleviate symptoms and protect the myelin sheath from further damage. The current study aimed to investigate the possible therapeutic effects of combining vitamin D3 (Vit D3) and siponimod (Sipo) on enhancing remyelination and modulating microglia phenotypes in the cuprizone (CPZ) demyelination mouse model. The study was divided into two stages; demyelination (first 5 weeks) and remyelination (last 4 weeks). In the first 5 weeks, 85 mice were randomly divided into two groups, control (n = 20, standard rodent chow) and CPZ (n = 65, 0.3% CPZ mixed with chow for 6 weeks, followed by 3 weeks of standard rodent chow). At week 5, the CPZ group was re-divided into four groups (n = 14) for remyelination stages; untreated CPZ (0.2 ml of CMC orally), CPZ+Vit D3 (800 IU/kg Vit D3 orally), CPZ+Sipo (1.5 mg/kg Sipo orally), and CPZ+Vit D3 (800 IU/kg Vit D3) + Sipo (1.5 mg/kg Sipo orally). Various behavioral tasks were performed to evaluate motor performance. Luxol Fast Blue (LFB) staining, the expression level of myelin basic protein (MBP), and M1/M2 microglia phenotype genes were assessed in the corpus callosum (CC). The results showed that the combination of Vit D3 and Sipo improved behavioral deficits, significantly promoted remyelination, and modulated expression levels of microglia phenotype genes in the CC at early and late remyelination stages. These results demonstrate for the first time that a combination of Vit D3 and Sipo can improve the remyelination process in the cuprizone (CPZ) mouse model by attenuating the M1 microglia phenotype. This may help to improve the treatment of MS patients.

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“…[ 132 ] Supplementation with vitamin D improves the morphology of mitochondrial ridges by regulating the expression of mitofusin‐1/2 (MFN1/2), optic atrophy 1 (OPA1), and dynein‐associated protein 1 (Drp1), thereby restoring ATP production and reducing ROS generation in skeletal muscle. [ 140 ] Sarcopenia is correlated with diminished expression of the vitamin D receptor (VDR). [ 132,149 ] Animal studies have shown that VDR can prevent skeletal muscle atrophy by inhibiting the local renin‐angiotensin system.…”

Section: Nutritional Support Strategies and Underlying Mechanismsmentioning

confidence: 99%

Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms

Shen,

Zhang,

Dai

et al. 2024

Molecular Nutrition Food Res

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Skeletal muscle can undergo detrimental changes in various diseases, leading to muscle dysfunction and atrophy, thus severely affecting people's lives. Along with exercise, there is a growing interest in the potential of nutritional support against muscle atrophy. This review provides a brief overview of the molecular mechanisms driving skeletal muscle atrophy and summarizes recent advances in nutritional interventions for preventing and treating muscle atrophy. The nutritional supplements include amino acids and their derivatives (such as leucine, β‐hydroxy, β‐methylbutyrate, and creatine), various antioxidant supplements (like Coenzyme Q10 and mitoquinone, resveratrol, curcumin, quercetin, Omega 3 fatty acids), minerals (such as magnesium and selenium), and vitamins (such as vitamin B, vitamin C, vitamin D, and vitamin E), as well as probiotics and prebiotics (like Lactobacillus, Bifidobacterium, and 1‐kestose). Furthermore, the study discusses the impact of a combined approach involving nutritional support and physical therapy to prevent muscle atrophy, suggests appropriate multi‐nutritional and multi‐modal interventions based on individual conditions to optimize treatment outcomes, and enhances the recovery of muscle function for patients. By understanding the molecular mechanisms behind skeletal muscle atrophy and implementing appropriate interventions, it is possible to enhance the recovery of muscle function and improve patients' quality of life.

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Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape

Cited by 14 publications

References 53 publications

Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health

Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health

Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis

Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms

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