Vitamin D supplementation increases calcium absorption without a threshold effect

Aloia, John F.; Dhaliwal, Ruban; Shieh, Albert; Mikhail, Mageda; Fazzari, Melissa; Ragolia, Louis; Abrams, Steven A.

doi:10.3945/ajcn.113.067199

Cited by 71 publications

(49 citation statements)

References 28 publications

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“…According to He aney and cols., individuals with 35 ng/mL of 25(OH)D presented higher absorption than those with 25 ng/mL (26) (B). Increase of calcium absorption with increasing dose of vitamin D 3 or serum 25(OH)D was recently ob served, but there is no evidence of what the minimum value of 25(OH)D to ensure calcium absorption from the intestine in the range of 1652 ng/mL evaluated in the study (27).…”

Section: What Are the Effects On Bone Metabolism?mentioning

confidence: 99%

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maeda

Borba

Camargo

et al. 2014

Arq Bras Endocrinol Metab

224

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Objective: The objective is to present an update on the diagnosis and treatment of hypovitaminosis D, based on the most recent scientific evidence. Materials and methods: The Department of Bone and Mineral Metabolism of the Brazilian Society of Endocrinology and Metabology (SBEM) was invited to generate a document following the rules of the Brazilian Medical Association (AMB) Guidelines Program. Data search was performed using PubMed, Lilacs and SciELO and the evidence was classified in recommendation levels, according to the scientific strength and study type. Conclusion: A scientific update regarding hypovitaminosis D was presented to serve as the basis for the diagnosis and treatment of this condition in Brazil.

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Section: What Are the Effects On Bone Metabolism?mentioning

confidence: 99%

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maeda

Borba

Camargo

et al. 2014

Arq Bras Endocrinol Metab

224

View full text Add to dashboard Cite

show abstract

“…Active absorption is considered to be more important when dietary intake of calcium is limited. Multiple dual or single isotope studies carried out in adults and adolescents have examined the level of 25OHD at which intestinal calcium absorption is maximized or reaches a plateau, and have established that a plateau occurs below 20 nM 25OHD, with very little increase (if any) in intestinal calcium absorption above that value (7,24,26,306,650,774). Secondary hyperparathyroidism occurs at lower levels of 25OHD and maintains high levels of calcitriol despite the reduced availability of substrate, which may be why vitamin D deficiency does not impair intestinal calcium absorption until the 25OHD level is below 20 nM (650).…”

Section: Human Datamentioning

confidence: 99%

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

362

524

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During pregnancy and lactation, female physiology adapts to meet the added nutritional demands of fetuses and neonates. An average full-term fetus contains ϳ30 g calcium, 20 g phosphorus, and 0.8 g magnesium. About 80% of mineral is accreted during the third trimester; calcium transfers at 300-350 mg/day during the final 6 wk. The neonate requires 200 mg calcium daily from milk during the first 6 mo, and 120 mg calcium from milk during the second 6 mo (additional calcium comes from solid foods). Calcium transfers can be more than double and triple these values, respectively, in women who nurse twins and triplets. About 25% of dietary calcium is normally absorbed in healthy adults. Average maternal calcium intakes in American and Canadian women are insufficient to meet the fetal and neonatal calcium requirements if normal efficiency of intestinal calcium absorption is relied upon. However, several adaptations are invoked to meet the fetal and neonatal demands for mineral without requiring increased intakes by the mother. During pregnancy the efficiency of intestinal calcium absorption doubles, whereas during lactation the maternal skeleton is resorbed to provide calcium for milk. This review addresses our current knowledge regarding maternal adaptations in mineral and skeletal homeostasis that occur during pregnancy, lactation, and post-weaning recovery. Also considered are the impacts that these adaptations have on biochemical and hormonal parameters of mineral homeostasis, the consequences for long-term skeletal health, and the presentation and management of disorders of mineral and bone metabolism.

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“…By contrast, a case‐control study by Zanardo et al (2014) of 25 overweight/obese and 25 nonoverweight/obese Italian mothers found women with higher BMI had more body dissatisfaction, yet were more likely to still be breastfeeding at six months postpartum. However, analysis of longitudinal data for 2824 women in the Infant Feeding Practices Study II showed overweight/obese women had similar intention to breastfeed as peers, but were less likely to initiate breastfeeding, and terminated breastfeeding sooner (Hauff, Leonard, & Rasmussen, 2014). …”

Section: Introductionmentioning

confidence: 99%

Influence of weight concerns on breastfeeding: Evidence from the Norwegian mother and child cohort study

Han

Brewis

2017

American J Hum Biol

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ObjectivesHigh body mass index (BMI) often predicts truncated breastfeeding, although why is unclear. We test a proposed mediating role of body concerns on breastfeeding initiation and child's age at weaning using longitudinal data for 55,522 mothers from the Norwegian Mother and Child Cohort Study (MoBa).MethodsA linear regression‐based mediation analysis with bootstrapping estimates the indirect effects of BMI on breastfeeding decisions (ever‐initiation of breastfeeding, child's age at weaning, and duration of any breastfeeding beyond six months) through the variables of concern around prepregnancy weight and weight gains due to pregnancy.ResultsContrary to prediction, Norwegian mothers with greater prepregnancy weight concerns had a higher likelihood of initiating breastfeeding. Concerns about weight gain during pregnancy, however, predicted earlier weaning. This relationship was the same for higher and lower BMI mothers.ConclusionIn this very large sample, body image affects some breastfeeding decisions. However, this effect is independent of mother's body size.

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Vitamin D supplementation increases calcium absorption without a threshold effect

Abstract: No evidence of a threshold of calcium absorption was found with a serum 25(OH)D range from 40 to 130 nmol/L. Calcium absorption in this range is not a useful biomarker to determine nutritional recommendations for vitamin D.

Cited by 71 publications

References 28 publications

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Influence of weight concerns on breastfeeding: Evidence from the Norwegian mother and child cohort study

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