Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: An open label randomized prospective study from Eastern India

Dutta, Deep; Mondal, Samim Ali; Choudhuri, Subhadip; Maisnam, Indira; Reza, Abu Hena Hasanoor; Bhattacharya, Bhaswar B.; Chowdhury, Subhankar; Mukhopadhyay, Satinath

doi:10.1016/j.diabres.2013.12.044

Cited by 108 publications

(133 citation statements)

References 18 publications

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“…Based on the HbA1c data of the prediabetic people from other studies [27, 28], with a standard deviation of 0.5 units in HbA1c, a sample size of 17 participants in each treatment group will give 80% power to detect a 0.5-unit fall in HbA1c at a type 1 error (alpha) of 0.05. To allow for dropouts we will recruit 4 × 20 = 80 participants according to the inclusion criteria.…”

Section: Method/designmentioning

confidence: 99%

Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

Thota

Acharya

Abbott

et al. 2016

Trials

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BackgroundLifestyle interventions, including increase in physical activity and dietary counselling, have shown the ability to prevent type 2 diabetes (T2D) in high-risk state individuals, but the prevalence is still skyrocketing in Australia, in line with global prevalence. Currently, no medicines are approved by the Therapeutic Goods Administration in Australia for the management of prediabetes. Therefore, there is a need of developing a safer, biologically efficacious and cost-effective alternative for delaying the transition of individual health state from prediabetes into T2D. In the current trial we propose to evaluate the effects of curcumin and/or long-chain omega-3 polyunsaturated fatty acids on improving glycosylated haemoglobin as a primary outcome, along with secondary outcomes of glycaemic indices, lipid profile and inflammatory parameters.Methods/designEighty individuals diagnosed with prediabetes, aged between 30 and 70 years, will be randomly assigned to double placebo, curcumin alone, fish oil alone or double active groups according to a computer-generated randomisation sequence for 12 weeks. At baseline and post-intervention visits participants will be asked to provide blood samples and undergo body composition measurements. A blood sample is used for estimating glycaemic profiles, lipid profiles and inflammatory parameters (C-reactive protein, whole blood cell count, adiponectin, leptin, interleukin-6). The interim visit includes review on compliance with supplements based on capsule log and capsule count, adverse events and anthropometric measurements. In addition to these procedures, participants provide self-reported questionnaires on dietary intake (using a 3-day food record), a physical activity questionnaire and medical history.DiscussionThis trial aims to determine whether curcumin and/or long-chain omega-3 polyunsaturated fatty acids affect surrogate markers of glycaemic control which is relevant to delaying T2D. To date 38 participants completed the trial. No changes have been made to the clinical protocol post recruitment. If successful, this trial will provide considerable evidence for performing a larger trial to investigate whether this combination can be administered for preventing or delaying the onset of T2D in high-risk individuals.Trial registration ACTRN12615000559516, registered on 29 May 2015).Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-016-1702-9) contains supplementary material, which is available to authorized users.

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Section: Method/designmentioning

confidence: 99%

Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

Thota

Acharya

Abbott

et al. 2016

Trials

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“…12 In diabetic group, 41.7% patients with good glycemic status fell into the deficient and insufficiency group each, and only 16.6% patients had sufficient amounts of vitamin D. Whereas no patient with poor glycemic status had sufficient values of vitamin D. 84.2 % had deficient vitamin D3. Kumar RA et al, have done a study in south Indians to compute the prevalence of vitamin D deficiency in 370 type 2 diabetics, deficiency was present in 83%, insufficiency in 13.8% and only 3.2% had normal vitamin D levels.…”

Section: Discussionmentioning

confidence: 99%

Status of vitamin D3 level and its co-relation with the glycaemic status in Indian population

et al. 2017

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INTRODUCTIONDiabetes and vitamin D deficiency are global epidemics. Presently, around 285 million people have diabetes and this number is expected to reach 438 million by the year 2030.1 Given the burden of diabetes and its complications, researchers have long been exploring the role of potentially modifiable factors to identify at-risk individuals prior to diagnosis. Our focus has now shifted to prediabetes, which is an intermediate form of dysglycemia on a spectrum ranging from normal to overt diabetes.2 As per American Diabetes Association, a fasting glucose of 100 -<126 mg/dL, a 2-hour plasma glucose of 140 -<200 mg/dL after a 75-g OGT test, or HbA1c 5.7% (39mmol/mol) to <6.5% (48mmol/mol) defines prediabetes. Diabetes mellitus is diagnosed when fasting glucose >126mg/dL, 2-hour plasma glucose ≥200 mg/dL or HbA1c ≥6.5% (48mmol/mol). Despite the advances in the diagnosis and management of diabetes, achieving normoglycemia or optimal glycemic control is still considered challenging.4 This is because care of prediabetes and type 2 diabetes warrants intense life-style adaptations, polypharmacy and insulin centered regimens. ABSTRACT Background:The growing incidence of diabetes, consequent devastating morbidity, increasing mortality highlight the need for innovative approaches for prevention and management of disease. Pleiotropic hormonal effect of vitamin D3 has speculated its role in pathogenesis of diabetes. This study aims to assess vitamin D3 levels in study and control group and co-relate its level with HbA1c. Methods: This is a cross-sectional observational study done on randomly selected patients from January 2015 to September 2016. Patients were divided into 2 groups: control group and study group including pre-diabetics and diabetics. Venous sample for serum 25-OH vitamin D and HbA1c were collected. Results: 109 subjects were included in the study: 37 controls, 41 pre-diabetics, 31 diabetics. Out of the 37 healthy subjects, 14 (37.9%) had sufficient levels, 11 (29.7%) had insufficient levels whereas 12 (32.4%) were deficient in Serum vitamin D3 levels. Vitamin D3 deficiency was prevalent in 46.3% pre-diabetics, 41.7% diabetics with good glycaemic control and 84.2% diabetics with poor glycaemic control. Conclusions: Using Pearson Chi square, inverse co-relation was found between glycated haemoglobin and vitamin D3 levels (p<0.003).

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“…Previous studies have demonstrated an association between low vitamin D status and the risk of several diseases, including muscle weakness, cardiovascular disease, insulin resistance, and immune system disorders (1)(2)(3)(4). Moreover, vitamin D suppresses cancer cell growth through its nonclassical roles of antiproliferative, antiapoptotic, and prodifferentiating effects (5).…”

Section: Introductionmentioning

confidence: 97%

Low Serum 25 Hydroxyvitamin D Is Associated with Poor Clinicopathologic Characteristics in Female Patients with Papillary Thyroid Cancer

Ryang

Hyun

et al. 2014

Thyroid

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Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: An open label randomized prospective study from Eastern India

Cited by 108 publications

References 18 publications

Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

Curcumin and long-chain Omega-3 polyunsaturated fatty acids for Prevention of type 2 Diabetes (COP-D): study protocol for a randomised controlled trial

Status of vitamin D3 level and its co-relation with the glycaemic status in Indian population

Low Serum 25 Hydroxyvitamin D Is Associated with Poor Clinicopathologic Characteristics in Female Patients with Papillary Thyroid Cancer

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