Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health

Tan, May Loong; Abrams, Steven A.; Osborn, David A

doi:10.1002/14651858.cd013046.pub2

Cited by 40 publications

(28 citation statements)

References 173 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our ndings are consistent with previous studies that showed low prevalences of vitamin D de ciency and insu ciency (≤ 20 ng/mL) when exclusively breastfed infants were supplemented with 400 IU of vitamin D daily (21,22,23). A recent systematic review determined the effect of vitamin D supplementation in breastfed infants compared with placebo (24). The authors found six and four randomized controlled trials that determined the primary outcome of infants' vitamin D concentration and vitamin D status, respectively.…”

Section: Discussionsupporting

confidence: 90%

Vitamin D Status in Full-term Exclusively Breastfed Infants versus Full-term Breastfed Infants Receiving Vitamin D Supplementation in Thailand: A Randomized Controlled Trial

Ruangkit

Suwannachat

Wantanakorn

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Many international medical organizations recommend vitamin D supplementation for infants, especially exclusively breastfed infants. In Thailand, however, data regarding the vitamin D status in Thai infants are lacking. Such data would help to support physician decisions and guide medical practice. Methods: Full-term, exclusively breastfed infants were randomized into two groups at 2 months of age to continue exclusive breastfeeding either without vitamin D supplementation (control group, n = 44) or with vitamin D3 supplementation at 400 IU/day (intervention group, n = 43) until 6 months of age. At 6 months, the serum vitamin D (25OHD) of the infants and their mothers, serum bone marker, and infants' growth parameters were compared between the two groups. Results: The infants' serum 25OHD concentration was lower in the control group than intervention group (20.57 ± 12.66 vs. 46.01 ± 16.42 ng/mL, p < 0.01). More infants had vitamin D sufficiency (25OHD of >20 ng/mL) in the intervention group than control group (93.0% vs. 43.2%, p < 0.01). Vitamin D supplementation in breastfed infants increased the mean serum 25OHD concentration by 25.66 ng/mL (95% confidence interval, 19.07–32.25; p < 0.001) and contributed to an 88.7% decrease in the prevalence of vitamin D insufficiency/deficiency (relative risk, 0.11; 95% confidence interval, 0.04–0.35; p < 0.01).Conclusions: Most full-term, exclusively breastfed Thai infants have serum vitamin D concentration below sufficiency level at 6 months of age. However, vitamin D supplementation (400 IU/day) improves their vitamin D status and prevents vitamin D deficiency.Trial registration: The study was pre-registered in the Thai Clinical Trials Registry (TCTR20190622001) on 22/06/2019.

show abstract

Section: Discussionsupporting

confidence: 90%

Vitamin D Status in Full-term Exclusively Breastfed Infants versus Full-term Breastfed Infants Receiving Vitamin D Supplementation in Thailand: A Randomized Controlled Trial

Ruangkit

Suwannachat

Wantanakorn

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…A Cochrane systematic review in 2020 showed that infants receiving vitamin D supplementation had a 9.1 ng/mL higher 25(OH)D level than those receiving placebo from the start of treatment to 6 months of age. ( 19 ) In the present study, the mean 25(OH)D concentrations in the placebo group decreased by 6.0 ng/mL (from 19.6 to 13.6 ng/mL). Other studies have reported similar results.…”

Section: Discussionsupporting

confidence: 43%

Effect of Oral Vitamin D3 Supplementation in Exclusively Breastfed Newborns: Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

Lin

Sung

et al. 2020

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Exclusively breastfed infants are at a high risk of vitamin D deficiency. Few studies have evaluated the effects of vitamin D supplementation. Hence, we conducted a prospective randomized controlled trial investigating the effects of oral vitamin D3 400 IU/d supplementation in exclusively breastfed newborns. Serum 25-hydroxy-vitamin D (25[OH]D) levels in pregnant women and their newborns were evaluated. Breastfed newborns were randomized to one of two regimens at age 10 days. One group received vitamin D3 supplementation at a dose of 400 IU/d (vD-400 group), whereas the placebo group received a liquid product without vitamin D3. Outcomes were assessed at 4 months of age. A total of 92 pregnant women and their infants were enrolled, and the data of 72 infants (37 in the vD-400 group and 35 in the placebo group) who completed the study at 4 months of age were assessed. The results showed severe vitamin D deficiency in 15.2% of mothers before delivery, while 54.3% had vitamin D deficiency. Moreover, 15.2% of newborns presented with severe vitamin D deficiency at birth, while 52.2% had vitamin D deficiency. Maternal vitamin D levels were significantly correlated with infant vitamin D levels at birth (r = 0.816, p < 0.001). At 4 months of age, weight, head circumference, serum 25(OH)D, phosphorus, and intact parathyroid hormone levels significantly differed between the vD-400 and placebo groups. However, the body length and bone mineral density of the two groups did not differ significantly. Regardless of vitamin D supplementation, participants with severe vitamin D deficiency had significantly higher intact parathyroid hormone levels and lower bone mineral content. In conclusion, among exclusively breastfed infants, oral supplementation with vitamin D3 at a dose of 400 IU/d from age 10 days increased 25(OH)D concentrations at 4 months of age, but it did not affect bone mineralization.

show abstract

“…For breastfed infants, vitamin D supplementation 400 IU/day for up to six months increases 25-OH vitamin D levels and reduces vitamin D insu ciency, but there was insu cient evidence to assess its effect on vitamin D de ciency and bone health. For higher-risk infants who are breastfeeding, maternal vitamin D supplementation reduces vitamin D insu ciency and vitamin D de ciency, but there was insu cient evidence to determine an effect on bone health (27).…”

Section: Discussionmentioning

confidence: 99%

Effect of Higher vs Standard Dosage of Vitamin D3 Supplementation on Bone Strength and bone metabolism in child with chronic kidney disease

Feng

et al. 2022

Preprint

View full text Add to dashboard Cite

We investigated the effects of high VS. standard dose of vitamin D supplementation on kidney function and bone metabolism in children with chronic kidney disease (CKD). In all, 75 participants receive 2000 IU/D of vitamin D oral supplementation vs 75 participants who were randomized to receive 400 IU/d for a minimum of 4 months. We investigated the effects of vitamin D supplementation on kidney-related indicators and bone metabolism-related indicators at different doses. A total of 158 participants were screened and 150 met inclusion criteria. The indicators of chronic kidney disease, such as eGFR and serum uric acid, was negatively correlated with 25(OH)D levels and BMD. Serum 25(OH)D level and osteocalcin were positively correlated with spine BMD. The standard dose of vitamin D can improve serum uric acid levels, but high doses of vitamin D supplementation had no significant effect on serum uric acid. The high doses of vitamin D supplementation also improve alkaline phosphatase levels. When comparing the results of different doses of vitamin D supplementation, it was found that high-dose vitamin D supplementation did not improve bone density in the spine and femur neck relative to the standard dose of vitamin D, but improved low calciumemia and PINP levels. Among the children with clinical kidney disease, treatment with Vitamin D for 4 months at high dose, compare with standard dose of Vitamin D treatment, resulted in statistically significantly improve kidney function but no significantly different in bone metabolism.

show abstract

Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health

Cited by 40 publications

References 173 publications

Vitamin D Status in Full-term Exclusively Breastfed Infants versus Full-term Breastfed Infants Receiving Vitamin D Supplementation in Thailand: A Randomized Controlled Trial

Vitamin D Status in Full-term Exclusively Breastfed Infants versus Full-term Breastfed Infants Receiving Vitamin D Supplementation in Thailand: A Randomized Controlled Trial

Effect of Oral Vitamin D3 Supplementation in Exclusively Breastfed Newborns: Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

Effect of Higher vs Standard Dosage of Vitamin D3 Supplementation on Bone Strength and bone metabolism in child with chronic kidney disease

Contact Info

Product

Resources

About