Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Mousa, Aya; Naderpoor, Negar; Teede, Helena; Scragg, Robert; Courten, Barbora de

doi:10.1093/nutrit/nux077

Cited by 91 publications

(72 citation statements)

References 61 publications

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“…However, we have previously shown that vitamin D may regulate, rather than suppress, NF‐κB, suggesting a more complex role for vitamin D in immunoregulation than previously described . Nevertheless, the anti‐inflammatory effects of vitamin D in vivo are supported by a recent meta‐analysis by our group of 20 RCTs with >1,200 patients with T2DM, where we showed that vitamin D‐treated groups had lower levels of C‐reactive protein and TNFα than had the placebo group.…”

Section: Vitamin D and Type 2 Diabetessupporting

confidence: 47%

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

2018

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Vitamin D deficiency has been implicated in the pathophysiology of cardiometabolic disorders including obesity, type 2 diabetes mellitus, cardiovascular diseases and polycystic ovary syndrome. Despite a large number of experimental and observational studies supporting a role for vitamin D in these pathologies, randomized controlled trials have reported little to no effect of vitamin D supplementation in the prevention or treatment of these disorders, although some results remain ambiguous. Polymorphisms in genes related to vitamin D metabolism, particularly in the vitamin D receptor and binding protein and the metabolizing enzyme 1-α-hydroxylase, have emerged as potential contributors to these divergent results. It is now becoming increasingly recognized that the effects and potential benefits of vitamin D supplementation may vary by several factors including vitamin D deficiency status, ethnicity and/or the presence of genetic variants, which affect individual responses to supplementation. However, these factors have seldom been explored in the available literature. Future trials should consider inter-individual differences and, in particular, should aim to clarify whether certain subgroups of individuals may benefit from vitamin D supplementation in the context of cardiometabolic health.

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Section: Vitamin D and Type 2 Diabetessupporting

confidence: 47%

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

2018

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“…Similar to our findings, vitamin D supplementation lowered inflammatory markers in patients with chronic heart failure (18) . In addition, vitamin D supplementation significantly reduced CRP concentrations in women with gestational diabetes mellitus (37) and patients with T2DM (48) . Moreover, the 8-week flaxseed oil supplementation led to a significant decrease in CRP levels in haemodialysis patients (49) .…”

Section: Effects On Inflammatory Markersmentioning

confidence: 96%

Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

et al. 2019

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This study was performed to evaluate the effects of vitamin D and n-3 fatty acids’ co-supplementation on markers of cardiometabolic risk in diabetic patients with CHD. This randomised, double-blinded, placebo-controlled trial was conducted among sixty-one vitamin D-deficient diabetic patients with CHD. At baseline, the range of serum 25-hydroxyvitamin D levels in study participants was 6·3–19·9 ng/ml. Subjects were randomly assigned into two groups either taking 50 000 IU vitamin D supplements every 2 weeks plus 2× 1000 mg/d n-3 fatty acids from flaxseed oil (n 30) or placebo (n 31) for 6 months. Vitamin D and n-3 fatty acids’ co-supplementation significantly reduced mean (P = 0·01) and maximum levels of left carotid intima–media thickness (CIMT) (P = 0·004), and mean (P = 0·02) and maximum levels of right CIMT (P = 0·003) compared with the placebo. In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β −0·40 mmol/l; 95 % CI −0·77, −0·03; P = 0·03), insulin (β −1·66 μIU/ml; 95 % CI −2·43, −0·89; P < 0·001), insulin resistance (β −0·49; 95 % CI −0·72, −0·25; P < 0·001) and LDL-cholesterol (β −0·21 mmol/l; 95 % CI −0·41, −0·01; P = 0·04), and a significant increase in insulin sensitivity (β +0·008; 95 % CI 0·004, 0·01; P = 0·001) and HDL-cholesterol (β +0·09 mmol/l; 95 % CI 0·01, 0·17; P = 0·02) compared with the placebo. Additionally, high-sensitivity C-reactive protein (β −1·56 mg/l; 95 % CI −2·65, −0·48; P = 0·005) was reduced in the supplemented group compared with the placebo group. Overall, vitamin D and n-3 fatty acids’ co-supplementation had beneficial effects on markers of cardiometabolic risk.

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“…It was also shown that T2D subjects with specific genotypes (VDR-Cdx-2AA) respond better to vitamin D supplementation [ 143 ]. A recent meta-analysis of RCTs suggests that vitamin D supplementation improves the chronic low-grade inflammation in T2D patients by reducing the C reactive protein level, TNF-α level, and the erythrocyte sedimentation rate by enhancing the leptin level [ 144 ]. However, in several other studies, no effect of vitamin D supplementation on β-cell function, insulin sensitivity, or glycemic outcomes in pre-diabetic or diet-treated diabetic patients was observed [ 126 , 145 , 146 , 147 , 148 ]…”

Section: Molecular and Clinical Studies Of Vitamin D In Various Dimentioning

confidence: 99%

Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies

Umar

Sastry

Chouchane

2018

IJMS

188

151

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The classical function of Vitamin D, which involves mineral balance and skeletal maintenance, has been known for many years. With the discovery of vitamin D receptors in various tissues, several other biological functions of vitamin D are increasingly recognized and its role in many human diseases like cancer, diabetes, hypertension, cardiovascular, and autoimmune and dermatological diseases is being extensively explored. The non-classical function of vitamin D involves regulation of cellular proliferation, differentiation, apoptosis, and innate and adaptive immunity. In this review, we discuss and summarize the latest findings on the non-classical functions of vitamin D at the cellular/molecular level and its role in complex human diseases.

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Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Abstract: PROSPERO CRD42016047755. Available at: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=47755 (9/15/2016).

Cited by 91 publications

References 61 publications

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies

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