Vitamin D supplementation during pregnancy and infancy reduces aeroallergen sensitization: a randomized controlled trial

Grant, Cameron C.; Crane, Julian; Mitchell, Edwin A.; Sinclair, Jan; Stewart, Alistair; Milne, Tania; Knight, Josh; Gilchrist, Catherine A.; Camargo, Carlos A.

doi:10.1111/all.12909

Cited by 71 publications

(68 citation statements)

References 42 publications

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“…Higher IgE levels have been shown to correspond with low vitamin D status in allergic individuals (5). A recent study showed that vitamin D supplementation of pregnant women resulted in lower serum IgE levels to mite antigens in the babies born to the vitamin D supplemented women (6). Vitamin D is a potential regulator of serum IgE and therefore susceptibility to allergic asthma.…”

Section: Introductionmentioning

confidence: 99%

Control of Circulating IgE by the Vitamin D Receptor In Vivo Involves B Cell Intrinsic and Extrinsic Mechanisms

James

Weaver

Cantorna

2017

The Journal of Immunology

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Vitamin D deficiency is associated with the development of asthma and allergy. The active form of vitamin D (1,25(OH)2D) regulates B cells in vitro and mice without the vitamin D receptor (VDR KO) have high serum IgE. Whole body VDR KO, T-VDR KO, B-VDR KO and vitamin D deficient mice were used to determine the targets of vitamin D in the regulation of IgE in vivo. Vitamin D deficient, VDR KO and B-VDR KO mice developed hyper-IgE, while T-VDR KO mice did not. The data show that IL-10 secretion by B cells and CD1d expression on B10 cells was lower in VDR KO mice. Mesenteric lymph node cultures from VDR KO and B-VDR KO mice secreted higher IgE ex vivo than WT cultures, and the addition of IL-10 eliminated the difference in IgE production between VDR KO and WT cultures. The increase in IgE in VDR KO mice was 2-fold greater than in the B-VDR KO mice suggesting that VDR deficiency in non-B cells contributes to hyper-IgE in vivo. Antibiotic depletion of the microbiota raised serum IgE 4-fold in both WT and VDR KO mice. The VDR directly and indirectly regulates IgE production in B cells. Vitamin D, through the VDR, is an environmental factor that helps to maintain low serum IgE responses.

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Section: Introductionmentioning

confidence: 99%

Control of Circulating IgE by the Vitamin D Receptor In Vivo Involves B Cell Intrinsic and Extrinsic Mechanisms

James

Weaver

Cantorna

2017

The Journal of Immunology

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“…Grant et al [101] randomized 260 woman/infant pairs to placebo/placebo, 1,000 IU/400 IU or 2,000 IU/800 IU. At enrolment, the mean serum 25(OH)D value was above the deficient level (63 nmol/L or 25 ng/mL).…”

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Larqué

Morales

Leis³

et al. 2018

Ann Nutr Metab

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Background: To what extent does the circulating 25-hydroxyvitamin D (25[OH]D) concentration help to meet the physiological needs of humans is an ongoing subject of debate. Remaining unexposed to the sun to reduce melanoma cancer risk, current lifestyle with less out door activities, and increasing obesity rates, which in turn increases the storage of vitamin D in the adipose tissue, are presumably factors that contribute to the substantial upsurge in the prevalence of vitamin D deficiency in humans. Since evidence is lacking regarding the appropriate cut-off points to define vitamin D status during pregnancy, references used to establish the intake recommendations and vitamin D content of prenatal vitamin supplements are quite conservative. Summary: The foetus depends fully on maternal 25(OH)D supply. 25(OH)D readily crosses the placenta and it is activated into 1,25(OH)₂D by foetal kidneys. Moreover, 1,25(OH)₂D can also be synthesized within the placenta to regulate placental metabolism. The importance of vitamin D during pregnancy for maintaining maternal calcium homeostasis and therefore for foetal bone development is well recognized; major discussions are in progress regarding the potential maternal detrimental effects on pregnancy outcomes, foetal development, and the long-term health of children. Interventional studies have also evaluated the effect of vitamin D for reduction on preterm birth and asthma programming. Key Messages: Clinically, by understanding the effects of vitamin D on perinatal outcomes, we could individualize antenatal counselling regarding vitamin D supplementation to ensure vitamin D repletion without increasing the risk of foetal hypercalcemia.

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“…The results obtained from a double-blind, randomized, parallel-group, placebo-controlled trial have revealed that supplementation of women (1000 IU/2000 IU) and infants (400 IU/800 IU) decreased sensitization of children to mites at 18 months [37].…”

Section: Pregnant Womenmentioning

confidence: 99%

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

Szymczak

Pawliczak

2018

Advances in Respiratory Medicine

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Asthma -a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients. Thus, it provides positive relation between vitamin D and asthma. Increased prevalence of asthma over the past decades causes elevated interest in vitamin D supplementation that is even reported as a ,,potential therapeutic option''. Unfortunately, results of clinical trials are inconsistent and do not provide supportive information about positive role of vitamin D in asthma. Little or even no effect of supplementation of vitamin D in improvement of onset, symptoms or progression of asthma was found in comprehensive interventional studies in adults, children and pregnant woman. This review critically summarized the last years evidence of a relation between vitamin D and asthma in adults, children and pregnant women.

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Vitamin D supplementation during pregnancy and infancy reduces aeroallergen sensitization: a randomized controlled trial

Abstract: Vitamin D supplementation during pregnancy and infancy reduces the proportion of children sensitized to mites at age 18 months. Preliminary data indicate a possible effect on primary care visits where asthma is diagnosed.

Cited by 71 publications

References 42 publications

Control of Circulating IgE by the Vitamin D Receptor In Vivo Involves B Cell Intrinsic and Extrinsic Mechanisms

Control of Circulating IgE by the Vitamin D Receptor In Vivo Involves B Cell Intrinsic and Extrinsic Mechanisms

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Can Vitamin D Help in Achieving Asthma Control? Vitamin D “Revisited”: An Updated Insight

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