Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani immigrants

Andersen, Rikke; Brot, Christine; Mejborn, Heddie; Mølgaard, Christian; Skovgaard, L. T.; Trolle, Ellen; Ovesen, Lars

doi:10.1038/ejcn.2009.18

Cited by 41 publications

(23 citation statements)

References 8 publications

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“…We are not aware of any report previously examining the impact of vitamin D 3 supplementation on lipid profile and highly sensitive CRP in obese adolescents. Similar findings, however, have been reported in adults [22,23,26]. …”

Section: Discussionsupporting

confidence: 31%

Effect of Vitamin D<sub>3</sub> Supplementation on Serum 25(OH)D, Lipids and Markers of Insulin Resistance in Obese Adolescents: A Prospective, Randomized, Placebo-Controlled Pilot Trial

et al. 2014

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Background/Aims: To determine the effect of vitamin D₃ supplementation on 25-hydroxyvitamin D [25(OH)D], lipid profile and markers of insulin resistance in obese adolescents. Methods: In this double-blind, randomized, placebo-controlled trial, 58 obese adolescents (n = 58; 12-18 years of age) received either vitamin D₃ (2,000 IU/day) or placebo for 12 weeks. Total 25(OH)D, fasting plasma glucose, insulin and lipid profile were measured at baseline and following supplementation. Results: The trial was completed by 44/58 enrolled participants. At the end of the 12 weeks, total serum 25(OH)D concentrations increased to a modest degree (median 6 ng/ml) in the vitamin D-supplemented group (p < 0.001). Supplementation showed no detectable changes in fasting plasma glucose, insulin, homeostatic model of assessment index (HOMA-IR), lipids and highly sensitive C-reactive protein. Conclusions: 12 weeks of vitamin D₃ supplementation in obese adolescents with 2,000 IU once daily resulted in a modest increase in 25(OH)D concentration in obese adolescents, but did not affect the lipid profile and markers of insulin resistance and inflammation. Further studies with higher doses of vitamin D₃ and/or longer duration of supplementation are needed to understand if vitamin D₃ supplementation can impact lipid profiles and markers of insulin resistance and inflammation in obese children.

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Section: Discussionsupporting

confidence: 31%

Effect of Vitamin D<sub>3</sub> Supplementation on Serum 25(OH)D, Lipids and Markers of Insulin Resistance in Obese Adolescents: A Prospective, Randomized, Placebo-Controlled Pilot Trial

et al. 2014

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“…So far only a few such intervention studies have been reported. Regarding serum TAG concentrations, which appear to be strongly associated with serum 25(OH)D, we have in our study of overweight and obese subjects found no effect on serum TAG of 20 000-40 000 IU vitamin D per week given for 1 year (Jorde et al, 2009);Heikkinen et al (1997) found no effect by supplementation with 300 IU vitamin D for 3 years in 323 postmenopausal women; Andersen et al (2009) found no change in 173 Pakistani subjects living in Denmark and given vitamin D in daily doses of 400 or 800 IU for 1 year; whereas Zittermann et al (2009) in their study on 200 overweight subjects found a significant 13% decrease in the serum TAG in those given 3320 IU daily for 1 year. These discrepancies could be due to the doses of vitamin D given as well as differences between the study groups.…”

Section: Vitamin D and Serum Lipidsmentioning

confidence: 76%

High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile

et al. 2010

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Background/Objectives: Low serum 25-hydroxyvitamin D (25(OH)D) concentrations are related to increased mortality. One possible explanation could be an association between serum 25(OH)D and serum lipids. Subjects/Methods: The study was performed at the University of Tromsø, Northern Norway. In total, 8018 nonsmoking and 2087 smoking subjects were included in a cross-sectional study performed in 2008, and 1762 nonsmoking and 397 smoking subjects in a longitudinal study from 1994/1995 to 2008. Nonfasting serum 25(OH)D, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio and triacylglycerol (TAG) were measured. Results: After adjustment for gender, age, sample month and body mass index in the cross-sectional study, there was a significant increase in serum TC, HDL-C and LDL-C, and a significant decrease in serum LDL-C/HDL-C ratio and TAG across increasing serum 25(OH)D quartiles. For serum HDL-C and TAG in nonsmokers the differences between the means for the highest and lowest serum 25(OH)D quartiles were 6.0 and 18.5%, respectively. In the longitudinal study, an increase in serum 25(OH)D was associated with a significant decrease in serum TAG. Conclusions: There is a cross-sectional association between serum 25(OH)D and serum lipids, and a longitudinal association over 14 years between serum 25(OH)D and TAG, which may contribute to explain the relation between low serum 25(OH)D concentrations and mortality.

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“…65 years) were given either 500 mg Ca and 17·5 mg cholecalciferol or a placebo, no effect on CRP or IL-6 concentration was observed over 3 years in either subjects with impaired fasting glucose or normal fasting glucose concentrations (87) . A short-term supplementation trial (12-week duration) with 1000 mg Ca and 20 mg cholecalciferol daily of postmenopausal women (n 39) had no effect on circulating concentrations of IL-6, TNF-a or CRP (161) . More recently, a large RCT on overweight and obese subjects (n 334) showed no effect of supplementation with Ca (500 mg/d) plus cholecalciferol (500 or 1000 mg/week) for 1 year on a wide range of cytokines and other inflammatory markers (193) .…”

Section: Inflammationmentioning

confidence: 99%

Vitamin D and cardiometabolic health: a review of the evidence

Muldowney

Kiely

2010

Nutr. Res. Rev.

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The cardiometabolic syndrome (MetS) is a clustering of related metabolic abnormalities including abdominal adiposity, insulin resistance, hypertension, dyslipidaemia and increased inflammatory and thrombotic markers, which is linked to increased risk of type 2 diabetes, CVD and overall mortality. Several cross-sectional and prospective studies have shown an association between low vitamin D status, as indicated by concentrations of serum 25-hydroxyvitamin D (s25(OH)D), and increased prevalence of the MetS and individual CVD risk factors. These epidemiological observations are supported by mechanistic studies but experimental data are limited. The available data from intervention studies are largely confounded as most vitamin D supplementation trials were mainly carried out to explore the role of Ca in CVD and include Ca in the treatment arms. Inadequate consideration of seasonal effects on s25(OH)D concentrations is also a common design flaw in most studies. Further complications arise from shared risk factors such as adiposity and ageing, which predispose individuals to exhibit both a more pronounced risk profile and relatively lower s25(OH)D concentrations. In conclusion, while epidemiological associations are promising and a rationale for low vitamin D status as a potentially modifiable risk factor for CVD is supported by mechanistic data, suitable experimental data from appropriately designed trials are just beginning to emerge. As yet, this body of literature is too immature to draw firm conclusions on the role of vitamin D in CVD prevention. Carefully controlled vitamin D trials in well-described population groups using intervention doses that are titrated against target s25(OH)D concentrations could yield potentially valuable outcomes that may have a positive impact on CVD risk modification.

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Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani immigrants

Cited by 41 publications

References 8 publications

Effect of Vitamin D<sub>3</sub> Supplementation on Serum 25(OH)D, Lipids and Markers of Insulin Resistance in Obese Adolescents: A Prospective, Randomized, Placebo-Controlled Pilot Trial

Effect of Vitamin D<sub>3</sub> Supplementation on Serum 25(OH)D, Lipids and Markers of Insulin Resistance in Obese Adolescents: A Prospective, Randomized, Placebo-Controlled Pilot Trial

High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile

Vitamin D and cardiometabolic health: a review of the evidence

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