Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis

Li, Qinyuan; Zhou, Qi; Zhang, Guangli; Tian, Xiaoyin; Li, Yuanyuan; Wang, Zhili; Zhao, Yan; Chen, Yaolong; Luo, Zhengxiu

doi:10.3390/nu14193947

Cited by 24 publications

(25 citation statements)

References 65 publications

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“…These inconsistent conclusions of asthma exacerbation may be attributed to the variations in serum 25(OH)D concentrations among asthmatic children. Two of the included reviewsF I G U R E 1 PRISMA flow diagram.found that vitamin D supplementation significantly reduced the risk of asthma exacerbations only in the subgroup population whose serum 25(OH)D levels were low (<10 ng/mL for one review and <25 nmol/L for the other review) 18,19. Besides, while microbial supplementation has been extensively studied in the paediatric context, our analyses revealed negligible effects on children.A shift in the key intervention approaches has been observed from supplements and diet in the prenatal and infancy stages to exercise and weight management in the childhood stage.…”

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confidence: 70%

Section: Resultsmentioning

confidence: 99%

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Non‐pharmacological interventions for asthma prevention and management across the life course: Umbrella review

Tong,

Zhang,

Wang

et al. 2024

Clinical & Translational All

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BackgroundThe impact of non‐pharmacological interventions (NPIs) on asthma prevention and management is insufficiently examined. We aim to comprehensively evaluate and synthesize existing evidence regarding the effectiveness of various NPIs throughout the life course.MethodsWe conducted a systematic search and screening of reviews that examined the effectiveness of various NPIs on asthma prevention and control in the Cochrane Library, PubMed, Embase, and Ovid databases. Data extraction was performed by considering the type of NPIs and the life course stages of the target population. Recommendations were provided by considering the quality of review assessed using the AMSTAR2 tool and the consistency of findings across reviews.ResultsWe identified 145 reviews and mapped the evidence on the impact of 25 subtypes of NPIs on asthma prevention and control based on five stages of life course. Reviews indicated a shift of focus and various impacts of major NPIs on asthma prevention and control across life courses, while a few types of NPIs, such as physical exercise, appeared to be beneficial in children, adolescents and adults. Consistent and high‐level evidence was observed only for psychological intervention on asthma control and quality of life among adults and older adults. Potential benefit with high‐level evidence was reported on certain NPIs, such as vitamin D in reducing risk of developing asthma in offsprings in the prenatal stage, digital health interventions in improving asthma control from childhood to older adulthood, and breathing exercise in improving quality of life, asthma‐related symptoms and lung function in adulthood and older adulthood.ConclusionThis study emphasizes the significance of delivering NPIs to improve asthma prevention and management and highlights the heterogeneity regarding the impact of NPIs across life courses. High‐quality research is urgently needed to further strengthen the evidence base of NPIs and tailored interventions should be considered in guideline development.

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confidence: 70%

Section: Resultsmentioning

confidence: 99%

Non‐pharmacological interventions for asthma prevention and management across the life course: Umbrella review

Tong,

Zhang,

Wang

et al. 2024

Clinical & Translational All

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“…Vitamin D 3 deficiency is a risk factor for allergic diseases, especially in children (19). A study has shown that vitamin D 3 supplements can reduce the severity of atopic dermatitis and AR in children (20). Through animal experiments, some scholars have revealed that vitamin D 3 has a preventive and therapeutic effect on AR, which provides theoretical guidance for practical application (21).…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D3 deficiency can affect the efficacy of sublingual immunotherapy in children with allergic rhinitis: a retrospective cohort study

Li¹,

Cui²,

Zhang³

et al. 2023

J Thorac Dis

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Background: Sublingual immunotherapy (SLIT) is effective and convenient for many allergic patients but it is still ineffective for many children with allergic rhinitis (AR). In previous studies, most of the patients with poor efficacy of SLIT used the method of individualized adjustment of drug dosage. Currently, there are few reports on the relationship between serum vitamin D 3 level and the efficacy of SLIT.Methods: In this study, 153 patients with AR who received SLIT were selected as the study objects. All patients collected serum for vitamin D 3 test before treatment. The clinical characteristics of the patients were collected, and all patients were regularly followed up for at least 6 months. The improvement rates were assessed according to the combined symptom medication score (CSMS). A receiver operating characteristic (ROC) curve was drawn, and the optimal cut-off point was determined according to the Youden index.Univariate and multivariate logistic regression were used to analyze the relationship between serum vitamin D 3 and SLIT efficacy. The odds ratios (ORs) and 95% confidence intervals (CIs) were computed by logistic regression.Results: Of 153 AR patients, 101 patients entered the final statistical analysis. According to CSMS, 29.7% of patients in low response (LR) group. The mean vitamin D 3 level was (20.42±7.48) ng/mL. The optimal cutoff point for vitamin D 3 was 22.25 ng/mL. Univariate logistic regression analysis of SLIT efficacy showed that whether the patient also had a food allergy (P<0.001) or asthma (P=0.011), whether they used acarid products (P=0.002), and whether vitamin D 3 is sufficient (P=0.001) were significantly related to the efficacy of SLIT. Multivariate logistic regression analysis showed that after adjusting for whether the patient also had asthma and whether they had used acarid products, whether the patient also had a food allergy (OR: 12.13, 95% CI: 3.57-41.18, P<0.001) and whether vitamin D 3 is sufficient (OR: 22.21, 95% CI: 4.04-122.30, P<0.001) were independent factors affecting the efficacy of SLIT.Conclusions: Serum Vitamin D 3 deficiency can affect the efficacy of SLIT in children with AR. This study provided a new therapeutic approach for SLIT patients with poor efficacy.

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“…10 At present, research results have confirmed that the serum vitamin D levels of obese patients are significantly lower than those of normal weight individuals, 11 and the vitamin D levels of AD patients are also lower than those of healthy individuals. [12][13][14] Therefore, we hypothesized that vitamin D may play some roles in the relationship between obesity and AD. This study analyzed vitamin D levels in AD patients of different body mass index (BMI) classification and their correlation with Severity Scoring of Atopic Dermatitis (SCORAD), total immunoglobulin E (tIgE), and EOS, also provided important evidence for the involvement of vitamin D in the pathogenesis of overweight/obesity AD.…”

Section: Introductionmentioning

confidence: 99%

Serum 25-Hydroxyvitamin D Level Might Be a Useful Indicator of Disease Severity in Obese Children With Atopic Dermatitis: A Case-Control Study

Chen,

Fang,

Liu

et al. 2024

International Journal of Dermatology and Venereology

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Objective: To assess the relationship between the severity of atopic dermatitis (AD) in children of varying weight categories and their serum 25-hydroxyvitamin D [25(OH)D] levels. Methods: The study population comprised 899 patients with AD and 854 age- and sex-matched controls. The Mann-Whitney U test and Kruskal-Wallis H tests were used to assess differences between groups, and Spearman correlation analysis was used to test correlation. Results: The 25(OH)D level in the AD group was M (Q 25, Q 75), 24.0 (19.7, 28.4) ng/mL, which was significantly lower than the control group (26.4 [23.6, 29.9] ng/mL; Z = −3.34, P = 0.001). 25(OH)D levels in children with AD were negatively correlated with body mass index (r = −0.30, P < 0.001), Severity scoring of Atopic Dermatitis (SCORAD; r = −0.14, P < 0.001), total immunoglobulin E (r = −0.13, P < 0.001), and eosinophil (r = −0.08, P = 0.017). There were statistically significant differences in 25(OH)D (H = 18.46, P < 0.001), total immunoglobulin E (H = 9.13, P = 0.010), eosinophil (H = 67.17, P < 0.001), and SCORAD (H = 10.49, P = 0.005) among groups with different body mass index classification. The 25(OH)D levels were 22.3 (17.5, 27.1) ng/mL in the overweight AD group and 22.3 (17.6, 25.7) ng/mL in the obese AD group, which were significantly lower than those in the normal-weight AD group (24.7 [20.4, 25.5] ng/mL; P = 0.003, P = 0.004). 25(OH)D levels were negatively correlated with SCORAD in obese AD patients (r = −0.25, P = 0.010). Conclusion: Vitamin D insufficient or deficient is obvious in children AD patients. The 25(OH)D levels in the overweight/obese AD group are significantly lower than those in the normal-weight AD group. Vitamin D level is negatively correlated with SCORAD in obese children with AD.

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Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis

Cited by 24 publications

References 65 publications

Non‐pharmacological interventions for asthma prevention and management across the life course: Umbrella review

Non‐pharmacological interventions for asthma prevention and management across the life course: Umbrella review

Serum vitamin D3 deficiency can affect the efficacy of sublingual immunotherapy in children with allergic rhinitis: a retrospective cohort study

Serum 25-Hydroxyvitamin D Level Might Be a Useful Indicator of Disease Severity in Obese Children With Atopic Dermatitis: A Case-Control Study

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