Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD)

Eid, Alaa; Khoja, Sawsan; AlGhamdi, Shareefa A.; Alsufiani, Hadeil M.; Alzeben, Faten; Alhejaili, Nasim; Tayeb, Haythum O.; Tarazi, Frank I.

doi:10.1007/s11011-019-00486-1

Cited by 21 publications

(33 citation statements)

References 37 publications

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“…Thus, it is possible that vitamin D deficiency by aggravating anxiety and depressive symptoms may influence reactions to tinnitus. As vitamin D supplementation was effective in ameliorating the severity of anxiety disorders, its effectiveness in tinnitus treatment cannot be excluded [ 69 ].…”

Section: Resultsmentioning

confidence: 99%

The role of vitamin D in subjective tinnitus—A case-control study

et al. 2021

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Regarding the high prevalence of vitamin D (25(OH)D) deficiency in the population and its possible association with ear diseases, we aimed to investigate the 25(OH)Dserum level in patients with subjective, nonpulsating tinnitus and its effect on tinnitus severity. The study included 201 tinnitus patients and 99 controls. Patient clinical information, including tinnitus characteristics and severity according to Tinnitus Handicap Inventory (THI), loudness assessed by Visual Analogue Scale (VAS), audiometry, and the blood level of vitamin D, was recorded. The level of 25(OH)D in tinnitus patients was significantly decreased compared with the controls (19.86 ± 7.53 and 27.43 ± 8.85 ng/ml, respectively; P value < 0.0001). More patients in the tinnitus group were deficient in vitamin D, compared with the controls (50.7% vs. 22.2% respectively, p < 0.0001). Tinnitus patients with a lower serum level of 25(OH)D (≤15 ng/dl) were significantly younger, had a higher degree of tinnitus severity measured with THI and VAS scales, had higher triglyceride and TSH levels, and a lower HDL level compared with individuals who had higher 25(OH)D level (>15 ng/dl). There was a strong correlation between the 25(OH)D level and THI. Our findings suggest that a large proportion of tinnitus patients suffers from vitamin D deficiency and that the vitamin D level correlates with tinnitus impact. We recommend a vitamin D assessment for all tinnitus patients.

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Section: Resultsmentioning

confidence: 99%

The role of vitamin D in subjective tinnitus—A case-control study

et al. 2021

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“…Vitamin D, and its metabolism by CYP24A1, may also have a role in regulating the IDO and the kynurenine pathway, as suggested by a study looking at HIV-1 infection in Ugandans (91). This is also suggested in a study looking at the effects of vitamin D supplementation in general anxiety disorder patients, where vitamin D increased serotonin/melatonin and decreased neopterin levels (92). Such data would indicate that stress, including discrimination stress, may be interacting with decreased vitamin D to modulate processes relevant to SARS-CoV-2 severity and fatality as well as susceptibility.…”

Section: Viral Entry and Prodromal Factorsmentioning

confidence: 88%

COVID-19 pathophysiology: interactions of gut microbiome, melatonin, vitamin D, stress, kynurenine and the alpha 7 nicotinic receptor: Treatment implications

Anderson¹,

Reíter²

2020

Melatonin Res.

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As data emerges on the pathophysiological underpinnings of severe acute respiratory syndrome coronavirus (SARS-CoV)-2, it is clear that there are considerable variations in its susceptibility and severity/fatality, which give indications as to its pathophysiology and treatment. SARS-CoV-2 modulatory factors include age, vitamin D levels, cigarette smoking, gender and ethnicity as well as premorbid medical conditions, including diabetes, cancer, obesity, cardiovascular disease, and immune-compromised conditions. A complex picture is emerging, with an array of systemic physiological processes interacting including circadian, immune, intestinal, CNS and coagulation factors. This article reviews data on SARS-CoV-2 pathoetiology and pathophysiology. It is proposed that a decrease in pineal and systemic melatonin is an important driver of SARS-CoV-2 susceptibility and severity, with the loss of pineal melatonin's induction of the alpha 7 nicotinic acetylcholine receptor (α7nAChR) in pulmonary epithelial cells and immune cells being a powerful regulator of susceptibility and severity, respectively. Stress, including discrimination stress, and decreased vitamin D also regulate SARS-CoV-2, including via gut dysbiosis and permeability, with a resultant decrease in the short-chain fatty acid, butyrate, and increase in circulating lipopolysaccharide. Stress and cytokine induction of the kynurenine pathways, leads to aryl hydrocarbon receptor activation, which primes platelets for heightened activity, coagulation and thrombin production, thereby driving elevations in thrombin that underpin many SARS-CoV-2 fatalities. On the basis of these pathophysiological changes, prophylactic and symptomatic treatments are proposed, including the use of melatonin and α7nAChR agonism.

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“…A special case is the association between vitamin D status and cognitive impairment in acute ischemic stroke patients. In fact, a recent study suggested the involvement of vitamin D deficiency in cognitive and mood disorders in the elderly [94], in quality of life in postmenopausal women [95], and in general anxiety disorders [96]. In a prospective cohort study on 354 patients, vitamin D deficiency was independently associated with the development of cognitive impairment measured by Mini-Mental State Examination [69].…”

Section: Vitamin D and Outcome Of Strokementioning

confidence: 99%

Vitamin D and Rehabilitation after Stroke: Status of Art

Siotto¹,

Santoro²,

Aprile³

2020

Applied Sciences

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Stroke is the first cause of disability in the population and post-stroke patients admitted to rehabilitation units often present a malnutrition status which can influence nutritional indices and then vitamin levels. Vitamin D deficiency seems implicated beyond stroke severity and stroke risk, and also affects post-stroke recovery. Some studies on vitamin D levels and outcome in stroke patients are available but very few data on vitamin D levels and outcome after rehabilitation treatment are reported. This literature review shows the possible relationship between vitamin D deficiency and recovery in post-stroke patients undergoing rehabilitation treatment. Moreover, because several studies have reported that single nucleotide polymorphisms and promoter methylation in genes are involved in vitamin D metabolism and might affect circulating vitamin D levels, these aspects are evaluated in the current paper. From the studies evaluated in this review, it emerges that vitamin D deficiency could not only have an important role in the recovery of patients undergoing rehabilitation after a stroke, but that genetic and epigenetic factors related to vitamin D levels could have a crucial role on the rehabilitation outcome of patients after stroke. Therefore, further studies are necessary on stroke patients undergoing rehabilitation treatment, including: (a) the measurement of the 25(OH) vitamin D serum concentrations at admission and post rehabilitation treatment; (b) the identification of the presence/absence of CYP2R1, CYP27B1, CYP24A1 and VDR polymorphisms, and (c) analysis of the methylation levels of these genes pre- and post-rehabilitation treatment.

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Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD)

Cited by 21 publications

References 37 publications

The role of vitamin D in subjective tinnitus—A case-control study

The role of vitamin D in subjective tinnitus—A case-control study

COVID-19 pathophysiology: interactions of gut microbiome, melatonin, vitamin D, stress, kynurenine and the alpha 7 nicotinic receptor: Treatment implications

Vitamin D and Rehabilitation after Stroke: Status of Art

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