Vitamin D Supplementation Ameliorates Severity of Major Depressive Disorder

AlGhamdi, Shareefa A.; Alsulami, Nabilah; Khoja, Sawsan; Alsufiani, Hadeil M.; Tayeb, Haythum O.; Tarazi, Frank I.

doi:10.1007/s12031-019-01461-2

Cited by 42 publications

(49 citation statements)

References 45 publications

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“…Multiple studies have suggested that a diet low in ultra-processed foods and high in fruits and vegetables is protective against depression, with depressed patients consistently showing lower intakes of fruits, vegetables, fish, folate, calcium, and magnesium [19][20][21]. One small study found that vitamin D supplementation in conjunction with standard of care significantly decreased depressive symptoms [22]. A systematic review on the effect of dietary polyphenols on depression concluded that higher intake of polyphenols, commonly seen in the Mediterranean diet, is associated with a lower prevalence of depression [23].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Multimodal Online Lifestyle Intervention for Depressive Symptoms and Quality of Life in Individuals With a History of Major Depressive Disorder

Abbott¹,

Sherwin²,

Klopf³

et al. 2020

Cureus

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Background Major depressive disorder (MDD) is a complex bio-psycho-social syndrome that affects millions of individuals and is one of the leading causes of impaired quality of life (QOL). In addition to the symptoms of depression and low mood, many individuals with MDD also suffer from isolation without the sense of a supportive, surrounding community. Given the challenges of treating individuals with MDD, social isolation and a lack of communal connection, this randomized controlled trial was designed to determine the efficacy of a multimodal, online and community-based lifestyle intervention for improving depressive symptoms and QOL in individuals with a history of MDD.

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Section: Discussionmentioning

confidence: 99%

Efficacy of a Multimodal Online Lifestyle Intervention for Depressive Symptoms and Quality of Life in Individuals With a History of Major Depressive Disorder

Abbott¹,

Sherwin²,

Klopf³

et al. 2020

Cureus

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“…Many clinical studies have found depression, anxiety and cognitive impairment to be associated with low serum levels of 25-hydroxyvitamin D [25(OH)D], which is the major circulating form of vitamin D, in average weight people [5][6][7]. Recent research has also provided evidence for antidepressant properties of vitamin D supplementation [8,9].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency and depression in obese adults: a comparative observational study

et al. 2021

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Background Amongst the contributing factors of depression, vitamin D deficiency has increasingly drawn attention in recent years. This paper seeks to examine the association between serum vitamin D level and depression in patients with obesity. Methods In this comparative observational study, serum 25-hydroxyvitamin D [25(OH)D] levels were compared between obese individuals with depression (n = 174) and those without depression considering the effect of potential confounders. Participants were selected from males and females aged 18 to 60 years old visiting the outpatient obesity clinic of Rasoul-e Akram hospital, Tehran, Iran. The diagnosis of depressive disorder was made based on the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria. Additional clinical and laboratory data were collected from hospital electronic records. Mann–Whitney U test (nonparametric), Student’s t-test (parametric), and Chi-squared test were used to analyze the differences between the two groups. To examine age and gender differences in the relationship between vitamin D deficiency and depression, stratified analyses were conducted by age and gender groups. Results The mean 25(OH) D levels were significantly different between depressed and non-depressed groups (20 ± 15 vs. 27 ± 13, P < 0.001). Vitamin D insufficiency/deficiency was detected in 78 and 67% of the depressed and non-depressed groups, respectively, which was significantly different (P = 0.03). The associations between depression and the serum 25(OH) D levels were observed regardless of gender and age. The overall average vitamin D levels were not significantly different between total males and females (22 ± 13 vs. 23 ± 14, P = 0.49). The average level of vitamin D was higher in the older age group (40–60 years) compared to younger participants (18–39 years) (26 ± 15 vs. 21 ± 13, P = 0.004). Conclusion The present study provides additional evidence for the hypothesis that low vitamin D serum concentration is associated with depression in obese adults, and highlights the need for further research to determine whether this association is causal.

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“…The studies aiming to investigate the antidepressant effect of vitamin D supplementation when depression was already diagnosed observed conflicting results ( Alavi et al, 2019 ; Alghamdi et al, 2020 ; Okereke et al, 2020 ; Vellekkatt et al, 2020 ; Zhu et al, 2020 ). To mention some of them, in randomized clinical trials (RCT), Vellekkatt et al (2020) , Alghamdi et al (2020) , and Alavi et al (2019) observed a reduction of depressive symptoms after vitamin D supplementation in patients with different stages of depression. Nevertheless, Okereke et al (2020) and Zhu et al (2020) did not observe improvements in depressive symptoms after vitamin D supplementation.…”

Section: Vitamin D and Depressive Symptomsmentioning

confidence: 99%

Vitamin D, Depressive Symptoms, and Covid-19 Pandemic

et al. 2021

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Graphical AbstractRole of vitamin D in the development of depressive symptoms. The synthesis of vitamin D from sunlight is impaired by lockdown and social distance measures imposed by the governments around the world during COVID-10 pandemic. Endogenous vitamin D synthesis initiates in the skin when 7-dehydrocholesterol (7-DHC) is converted in pre-vitamin D3 and then vitamin D3 [25(OH)D3]. It is transported through blood circulation by the vitamin D binding protein (VDBP) to the liver, the kidney, and the brain, where can be converted in its the active form [1,25(OH)2D3]. In the brain, the biological effects of 1,25(OH)2D3 are largely mediated by vitamin D receptor (VDR) through genomic mechanisms, which influence several aspects of serotonin metabolism, such as increasing serotonin synthesis by induction of the tryptophan hydroxylase 2 (TPH2) gene expression; influencing the expression of serotonin reuptake transporter (SERT) and the levels of monoamine oxidase-A (MAO-A), responsible to serotonin catabolism; and indirectly may regulate the synthesis of melatonin that improve the circadian rhythm. This mechanism can be impaired during social isolation and consequent reduction of vitamin D due to low sun exposure during the pandemic, which could contribute to the development of depressive symptoms.

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Vitamin D Supplementation Ameliorates Severity of Major Depressive Disorder

Cited by 42 publications

References 45 publications

Efficacy of a Multimodal Online Lifestyle Intervention for Depressive Symptoms and Quality of Life in Individuals With a History of Major Depressive Disorder

Efficacy of a Multimodal Online Lifestyle Intervention for Depressive Symptoms and Quality of Life in Individuals With a History of Major Depressive Disorder

Vitamin D deficiency and depression in obese adults: a comparative observational study

Vitamin D, Depressive Symptoms, and Covid-19 Pandemic

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