Vitamin D₃ levels and bone mineral density in patients with psoriasis and/or psoriatic arthritis

Abstract

Limited data are available on the vitamin D 3 status and bone mineral density (BMD) of patients with psoriasis or with psoriatic arthritis. Our study intended to explore possible correlations between vitamin D status and BMD, as well as among these parameters and the features of the underlying disorder. Seventy-two patients with psoriasis/ or psoriatic arthritis (female : male ratio, 40:32; mean age, 58.5 AE 11.6 years; mean duration of follow up, 142.7 AE 147.7 months) participated in the study. We evaluated the characteristic clinical features of the underlying disease, performed bone densitometry of the lumbar spine and the hip region, measured the serum vitamin 25 (OH)D 3 levels of the patients, and undertook the statistical analysis of the relationships between the clinical and the laboratory parameters. The proportion of patients with a low BMD value did not exceed that seen in the general population. We found an inverse correlation between the serum level of vitamin 25(OH)D 3 and body mass index, as well as between the former and the severity of skin involvement. Furthermore, the activity of psoriatic arthritis was significantly higher in patients with inadequate vitamin D 3 status. In patients with psoriatic arthritis, BMD significantly exceeded the values measured in patients suffering from psoriatic skin lesions only. Our findings suggest the importance of evaluating the vitamin D 3 status and screening for comorbid conditions in patients with psoriasis or psoriatic arthritis. This appears justified, in particular, due to the possible role of hypovitaminosis D 3 in provoking the development of skin lesions and joint symptoms.

Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist

“…Therefore, low levels of vitamin D are negatively associated with markers of inflammatory activation (C-reactive protein, CRP) and obesity [35]. Moreover, other studies showed that serum vitamin D levels were also reduced in patients with psoriatic arthritis and being inversely linked to disease activity [46, 47] . …”

Cardiovascular and Metabolic Diseases Comorbid with Psoriasis: Beyond the Skin

“…In this context, it is intriguing that dipeptidyl peptidase-4 inhibitors, a new class of antidiabetic agents, have been shown to improve skin symptoms in some psoriasis patients (62). Because topical vitamin D3 application is effective in treating psoriasis (63), the vitamin D3 level and bone mineral density have been assessed (64, 65). In those studies, the serum level of vitamin 25(OH)D3 was inversely correlated with the severity of psoriasis (64).…”

“…Because topical vitamin D3 application is effective in treating psoriasis (63), the vitamin D3 level and bone mineral density have been assessed (64, 65). In those studies, the serum level of vitamin 25(OH)D3 was inversely correlated with the severity of psoriasis (64). Patients with a low bone mineral density showed a statistically significant longer average duration of psoriasis than those with better bone density (65).…”

Systemic Osteoporosis and Psoriatic Arthritis: Current Understanding of the Problem

“…В то же вре-мя в работе G. Kincse и соавт. [13] выявлена достоверно большая частота снижения МПК среди пациентов с ПсА и псориазом по сравнению со здоровыми женщинами и мужчинами в возрасте старше 50 лет (63,8; 32,3 и 23,6% соответственно). В исследовании B. Frediani и соавт.…”

“…Так, в работе G. Kincse и соавт. [13] показана достоверная ассоциация недостаточности витамина D с высокой активностью ПсА, в то же время в работе B. Baskan и соавт. [22] корреляция уровня вита-мина D с качеством жизни (PSAQoL), числом болезнен-ных суставов, показателями HAQ-S, MASES и BASDAI у больных ПсА была статистически незначимой.…”