Vitamin D<sub>3</sub> alleviates cognitive impairment through regulating inflammatory stress in db/db mice

Tan, Xiaomu; Gao, Lifang; Cai, Xiaxia; Zhang, Mingyuan; Huang, Dongxu; Dang, Qinyu; Bao, Lei

doi:10.1002/fsn3.2397

Cited by 6 publications

(7 citation statements)

References 64 publications

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“…Another study revealed age-induced memory deficits could be reversed with cholecalciferol supplementation with corresponding increases in hippocampal BDNF and NGF expression [ 71 ]. In a model of type 2 diabetes in mice, BDNF and phosphorylation of its downstream effector CREB are reduced in the brain, and cholecalciferol restores these and associated behavioural deficits [ 72 ].…”

Section: Vitamin D and Normal Brain Developmentmentioning

confidence: 99%

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Cui

Eyles

2022

Nutrients

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Twenty of the last one hundred years of vitamin D research have involved investigations of the brain as a target organ for this hormone. Our group was one of the first to investigate brain outcomes resulting from primarily restricting dietary vitamin D during brain development. With the advent of new molecular and neurochemical techniques in neuroscience, there has been increasing interest in the potential neuroprotective actions of vitamin D in response to a variety of adverse exposures and how this hormone could affect brain development and function. Rather than provide an exhaustive summary of this data and a listing of neurological or psychiatric conditions that vitamin D deficiency has been associated with, here, we provide an update on the actions of this vitamin in the brain and cellular processes vitamin D may be targeting in psychiatry and neurology.

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Section: Vitamin D and Normal Brain Developmentmentioning

confidence: 99%

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Cui

Eyles

2022

Nutrients

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“…More and more evidence shows that vitamin D not only participates in calcium and phosphorus metabolism, but also participates in many biological reactions other than bone metabolism, including a series of nervous system regulation processes 30 . Accumulating evidence has shown that vitamin D deficiency is associated with cognitive decline 31 . Mechanistically, vitamin D seems to regulate the brain's oxidative response by modulating cell growth factors 32,33 .…”

Section: Discussionmentioning

confidence: 99%

“…30 Accumulating evidence has shown that vitamin D deficiency is associated with cognitive decline. 31 Mechanistically, vitamin D seems to regulate the brain's oxidative response by modulating cell growth factors. 32,33 Durk et al showed that vitamin D treatment significantly reduced plaque density in the cortex and hippocampus, improved cognitive function, and enhanced learning and memory in rodent models of Alzheimer's disease and diabetes.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of 25-OH vitamin D levels predict cognitive impairments among acute coronary syndrome patients

Fu,

Li,

et al. 2023

Journal of Cardiovascular Medicine

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Background The cognitive impairment after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) has become a crucial clinical concern that cannot be ignored. However, studies on the early warning factors of cognitive impairment after PCI are still insufficient. Methods This study reviewed the postoperative cognitive function of 284 patients who underwent PCI in our hospital from June 2019 to June 2022. During the 21-day follow-up, all participants included in the analysis were divided into the cognitive impairment (CI) group (n = 82) and the noncognitive impairment (NCI) group (n = 186) according to their Montreal cognitive assessment (MoCA) scale. Participants’ serum 25(OH)D3 levels on admission and serum neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP) and S100β levels were measured 21 days after surgery. Results Age more than 65 years, hypertension, operation time longer than 60 min, left ventricular ejection fraction less than 50% and serum 25(OH)D3 less than 31.41 ng/ml were the risk factors for cognitive dysfunction in ACS patients 21 days after PCI. Serum levels of 25(OH)D3, NSE, S100β and GFAP were significantly higher in patients with cognitive impairment than in patients without cognitive impairment. Conclusion Postoperative serum NSE, S100β and GFAP levels were significantly negatively correlated with serum 25(OH)D3 levels at admission. The serum 25(OH)D3 level is a risk factor and predictor of cognitive impairment in patients with ACS after PCI.

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“…The neuroprotective, anti-inflammatory, and antioxidant properties of vitamin D have been widely studied in preclinical studies, which then led to the hypothesis that vitamin D could serve as a potentially modifiable risk factor for cognitive decline and neurodegenerative diseases [19][20][21], including the POCD 5 Mediators of Inflammation [5,8,22]. However, preclinical research on the function of VD3 in the development of POCD is still limited.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D3 Supplementation Attenuates Surgery-Induced Neuroinflammation and Cognitive Impairment by Regulating NLRP3 Inflammasome in Mice

Jiang

Huang

Gao

et al. 2022

Mediators of Inflammation

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Neuroinflammation plays a dominant role in the progression of postoperative cognitive dysfunction (POCD). Vitamin D has been known to have important regulatory functions in inflammation and immune response. The NOD-like receptor protein 3 (NLRP3) is an essential inflammasome in the inflammatory response and could be activated by anesthesia and surgery. In this study, male C57BL/6 mice aged 14–16 months were given VD3 for 14 days straight before having an open tibial fracture surgery. The animals were either sacrificed to obtain the hippocampus or tested in a Morris water maze test. Western blot was employed to estimate the levels of NLRP3, ASC, and caspase-1, immunohistochemistry was used to identify microglial activation, and an enzyme-linked immunosorbent assay was used to measure the expression of IL-18 and IL-1β, while using the corresponding assay kits to assess ROS and MDA levels to reflect the oxidative stress status. We showed that VD3 pretreatment significantly improved surgery-induced memory and cognitive dysfunctions in aged mice, which was linked to the inactivation of the NLRP3 inflammasome and the inhibition of neuroinflammation. This finding provided a novel preventative strategy for clinically reducing postoperative cognitive impairment in elderly surgical patients. This study has some limitations. Gender differences in the effects of VD3 were not considered, and only male mice were used. Additionally, VD3 was given as a preventative measure; however, it is unknown whether it has any therapeutic benefits for POCD mice. This trial is registered with ChiCTR-ROC-17010610.

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Vitamin D₃ alleviates cognitive impairment through regulating inflammatory stress in db/db mice

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 64 publications

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Serum levels of 25-OH vitamin D levels predict cognitive impairments among acute coronary syndrome patients

Vitamin D3 Supplementation Attenuates Surgery-Induced Neuroinflammation and Cognitive Impairment by Regulating NLRP3 Inflammasome in Mice

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Vitamin D3 alleviates cognitive impairment through regulating inflammatory stress in db/db mice

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 64 publications

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Vitamin D and the Central Nervous System: Causative and Preventative Mechanisms in Brain Disorders

Serum levels of 25-OH vitamin D levels predict cognitive impairments among acute coronary syndrome patients

Vitamin D3 Supplementation Attenuates Surgery-Induced Neuroinflammation and Cognitive Impairment by Regulating NLRP3 Inflammasome in Mice

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Vitamin D₃ alleviates cognitive impairment through regulating inflammatory stress in db/db mice