Vitamin D status of county hospital patients assessed by the DiaSorin LIAISON® 25-hydroxyvitamin D assay

French, Deborah; Gorgi, Akram W.; Ihenetu, Kenneth; Weeks, Marilyn A.; Lynch, Kara L.; Wu, Alan H.B.

doi:10.1016/j.cca.2010.10.013

Cited by 17 publications

(7 citation statements)

References 29 publications

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“…Mean calcium levels were 2.24 ± < 0.01 mmol/L for men, (α2 = 55.175; p < 0.001). Using generalised estimating equations analysis with odds ratios and adjusting for the covariate of age (Table II), we found that all the years prior to 2010 were associated with higher odds of vitamin D deficiency to Our data indicated that vitamin D deficiency was clearly prevalent in our population -(i) the frequency distribution of (29,32,33) and Denmark, (34) where a high degree of vitamin D deficiency was seen among the populations studied. According to Hirani et al, women were more likely to be vitamin D deficient than men.…”

Section: E Th O Dsmentioning

confidence: 67%

Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia

Quaggiotto¹,

Tran²,

Bhanugopan³

2014

smedj

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INTRODUCTIONCONCLUSION We found that vitamin D deficiency was prevalent in both men and women, with a higher prevalence in the latter, despite the substantial increased demand for 25(OH)D testing in our population over the decade. Vitamin D deficiency was associated with elevated PTH levels. Vitamin D toxicity was rare and only observed once during our study period. 25(OH)D levels decreased with age and varied with season, with the highest levels observed in late summer and the lowest in early spring.

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Section: E Th O Dsmentioning

confidence: 67%

Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia

Quaggiotto¹,

Tran²,

Bhanugopan³

2014

smedj

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“…COVID‐19 testing was done only by physician referral (based on clinical criteria of exposure to confirmed COVID‐19 patients or symptoms suggesting COVID‐19) using the AllplexTM 2019‐nCoV Assay (Seegene Inc., Seoul, Korea) [23]. According to LHS guidelines, blood was collected from fasting persons and transported on ice to the Center Laboratory for processing within 4 hours of collection using DiaSorin Chemiluminescence assay [24–27]. Data of each subject were collected from the LHS computerized database and included age, gender, SES, weight, height, BMI, current smoking status, psychiatric and somatic comorbidities, and hospitalizations as a result of the COVID‐19 infection.…”

Section: Methodsmentioning

confidence: 99%

Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study

et al. 2020

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Vitamin D deficiency is a worldwide pandemic. The aim of this study was to evaluate associations of plasma 25(OH)D levels with the likelihood of coronavirus disease 2019 (COVID‐19) infection and hospitalization. The study population included the 14 000 members of Leumit Health Services, who were tested for COVID‐19 infection from February 1st to April 30th, 2020, and who had at least one previous blood test for the plasma 25(OH)D level. ‘Suboptimal’ or ‘low’ plasma 25(OH)D level was defined as plasma 25‐hydroxyvitamin D, or 25(OH)D, concentration below the level of 30 ng/mL. Of 7807 individuals, 782 (10.02%) were COVID‐19‐positive, and 7025 (89.98%) COVID‐19‐negative. The mean plasma vitamin D level was significantly lower among those who tested positive than negative for COVID‐19 [19.00 ng/mL (95% confidence interval (CI) 18.41–19.59) vs. 20.55 (95% CI: 20.32–20.78)]. Univariate analysis demonstrated an association between the low plasma 25(OH)D level and increased likelihood of COVID‐19 infection [crude odds ratio (OR) of 1.58 (95% CI: 1.24–2.01, P < 0.001)], and of hospitalization due to the SARS‐CoV‐2 virus [crude OR of 2.09 (95% CI: 1.01–4.30, P < 0.05)]. In multivariate analyses that controlled for demographic variables, and psychiatric and somatic disorders, the adjusted OR of COVID‐19 infection [1.45 (95% CI: 1.08–1.95, P < 0.001)] and of hospitalization due to the SARS‐CoV‐2 virus [1.95 (95% CI: 0.98–4.845, P = 0.061)] were preserved. In the multivariate analyses, age over 50 years, male gender and low–medium socioeconomic status were also positively associated with the risk of COVID‐19 infection; age over 50 years was positively associated with the likelihood of hospitalization due to COVID‐19. We concluded that low plasma 25(OH)D levels appear to be an independent risk factor for COVID‐19 infection and hospitalization.

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“…The study period was from February 1 st to April 30 th 2020. The study population included all members of LHS who were tested for COVID-19 infection during the study period and who had at least one previous test for plasma 25 (24). According to LHS guidelines, blood was collected from fasting persons and transported on ice to the Center Laboratory for processing within 4 h of collection using DiaSorin Chemiluminescence assay (25)(26)(27)(28).…”

Section: Methodsmentioning

confidence: 99%

“…The study population included all members of LHS who were tested for COVID-19 infection during the study period and who had at least one previous test for plasma 25 (24). According to LHS guidelines, blood was collected from fasting persons and transported on ice to the Center Laboratory for processing within 4 h of collection using DiaSorin Chemiluminescence assay (25)(26)(27)(28). Data of each subject were collected from the LHS computerized database and included age, gender, socioeconomic status (SES), weight, height, body mass index, current smoking status, psychiatric and somatic comorbidities, and hospitalizations as a result of the COVID-19 infection.…”

Section: Methodsmentioning

confidence: 99%

Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study

Merzon

Tworowski

Gorohovski

et al. 2020

Preprint

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Aim: To evaluate associations of plasma 25(OH)D status with the likelihood of coronavirus disease (COVID-19) infection and hospitalization. Methods: The study population included the 14,000 members of Leumit Health Services who were tested for COVID-19 infection from February 1st to April 30th, 2020, and who had at least one previous blood test for plasma 25(OH)D level. "Suboptimal" or "low" plasma 25(OH)D level was defined as plasma 25-hydroxyvitamin D, or 25(OH)D, concentration below 30 ng/mL. Results: Of 7,807 individuals, 782 (10.1%) were COVID-19-positive, and 7,025 (89.9%) COVID-19-negative. The mean plasma vitamin D level was significantly lower among those who tested positive than negative for COVID-19 [19.00 ng/mL (95% confidence interval [CI] 18.41-19.59) vs. 20.55 (95% CI 20.32-20.78)]. Univariate analysis demonstrated an association between low plasma 25(OH)D level and increased likelihood of COVID-19 infection [crude odds ratio (OR) of 1.58 (95% CI 1.24-2.01, p<0.001)], and of hospitalization due to the SARS-CoV-2 virus [crude OR of 2.09 (95% CI 1.01-4.30, p<0.05)]. In multivariate analyses that controlled for demographic variables and psychiatric and somatic disorders, the adjusted OR of COVID-19 infection [1.45 (95% CI 1.08-1.95, p<0.001)], and of hospitalization due to the SARS-CoV-2 virus [1.95 (95% CI 0.98-4.845, p=0.061)] were preserved. In the multivariate analyses, age over 50 years, male gender and low-medium socioeconomic status were also positively associated with the risk of COVID-19 infection; age over 50 years was positively associated with the likelihood of hospitalization due to COVID-19.

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Vitamin D status of county hospital patients assessed by the DiaSorin LIAISON® 25-hydroxyvitamin D assay

Cited by 17 publications

References 29 publications

Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia

Vitamin D deficiency remains prevalent despite increased laboratory testing in New South Wales, Australia

Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study

Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study

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