Vitamin D Status of Ambulatory and Nonambulatory Mentally Retarded Children with and without Carbamazepine Treatment

Abstract

The subjects consisted of four groups: group 1 nonambulatory patients receiving carbamazepine; group 2 ambulatory patients receiving carbamazepine; group 3 nonambulatory patients receiving no drug, and group 4 ambulatory patients receiving no drugs. The serum 25-hydroxyvitamin D (25-OH-D) concentration was significantly lower in group 1 than in all other groups. There was no difference between the groups as regards the serum 1,25-dihydroxyvitamin D or 24,25-dihydroxyvitamin D concentration. Carbamazepine treatment lowers the serum 25-OH-D concentration, and inactivity which leads to a lower degree of time spent out-of-doors and thus a low exposure to sunlight still decreases the concentration. In this study a low dietary vitamin D intake probably was an aggravating factor.

Vitamin D status in children with attention‐deficit–hyperactivity disorder

“…Clinical trials have examined the association between vitamin D and mental retardation, depression, autism and behavioral disorders in children and adults . Smith et al .…”

“…Clinical trials have examined the association between vitamin D and mental retardation, depression, autism and behavioral disorders in children and adults. 16,[35][36][37] Smith et al found that vitamin D insufficiency is common in children with cystic fibrosis. 37 Mostafa and Al-Ayadhi suggested that autistic children had significantly lower serum 25-OH-vitamin D than healthy children.…”

The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy

“…This in turn would lead to increased PTH, which would lead to increases in bone turnover, with subsequent bone loss. A considerable number of studies have found decreased 25‐(OH)D levels in patients treated with CBZ relative to controls or patients taking a noninducing AED (Tjellesen & Christiansen, 1982; Hoikka et al., 1984; Gough et al., 1986; Lamberg‐Allardt et al., 1990; Mintzer et al., 2006; Kim et al., 2007). Interestingly, several studies do not consistently find significantly reduced serum vitamin D levels, and findings regarding serum calcium and PTH levels also are not consistent.…”

The Perils of Pathogen Discovery: Origin of a Novel Parvovirus-Like Hybrid Genome Traced to Nucleic Acid Extraction Spin Columns

“…The capsid gene was also highly divergent, with only 31% translated amino acid identity over 17% of the gene to the corresponding capsid gene in goose parvovirus (ACK86566.1). Sequences encoding a conserved P-loop nucleoside triphosphate (NTP)-binding domain (50) and N-terminal parvovirus coat domain (51) were detected in the replicase and capsid genes, respectively. The capsid gene also encoded a putative phospholipase A 2 (PLA 2 ) motif that is critical for parvovirus infectivity (52).…”