Vitamin D Status Is Negatively Correlated with Insulin Resistance in Chinese Type 2 Diabetes

Zhang, Jie; Ye, Jianhong; Guo, Gang; Lan, Zhenhao; Li, Xing; Pan, Zhiming; Rao, Xianming; Zheng, Zongji; Luo, Fangtao; Li, Lin; Zhang, Lin

doi:10.1155/2016/1794894

Cited by 41 publications

(48 citation statements)

References 60 publications

(62 reference statements)

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“…No significant changes in insulin resistance and sensitivity of our trial were similar to Jorde et al, 2010 study [40], and SUNNY trial [34]. However, some studies reported a significant improvement in HOMA-IR or QUICKI with vitamin D [43,44,47]. The reason may be changing fasting serum glucose and insulin levels after the intervention.…”

Section: Discussionsupporting

confidence: 78%

Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial

et al. 2020

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Background: Vitamin D (VD) may increase sirtuin 1 (SIRT1) and subsequently PPAR-γ coactivator 1α (PGC-1α) and irisin levels and these improvements may reduce insulin resistance (IR). The aim was to assess the effects of vitamin D supplementation on SIRT1, irisin, and IR in overweight/obese type 2 diabetes (T2D) patients. Methods: Ninety T2D males and females were recruited as a clinical trial study (mean of age and body mass index (BMI) of intervention and placebo groups were 50.05 ± 10.17 and 50.36 ± 10.2 yrs. and 31.37 ± 3.4 and 30.43 ± 3.2 kg/m 2 , respectively). The inclusion criteria were T2D, VD deficient, BMI > 25 kg/m 2 , and serum HbA1c < 8.5%. The exclusion criteria were using vitamin and mineral supplements, having any acute disease, recent modifying dose or type of drugs. The supplementation was 50,000 IU/week VD or placebo for 8 weeks. The demographic characteristics, anthropometrics, dietary intakes and physical activity status, sun exposure status, fasting blood sugar (FBS) and insulin, glycosylated hemoglobin (HbA1c), irisin, SIRT1, 25-hydroxy D3 (25(OH)VD), homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI) were determined. The significant P-value was ≤0.05. Results: The increase of serum VD, SIRT1, and irisin in the intervention group was significant (p < 0.001). HbA1c was decreased significantly by 1%. The changes in the other glucose indices (FBS, insulin, and IR) were non-significant. Conclusions: VD supplementation may improve T2D by decreasing HbA1c and increasing SIRT1 and irisin in VD deficient T2D patients. Further trials are suggested. Trial registration: Iranian Registry of Clinical Trials, IRCT201604202365N11. Registered 21/08/2016, http://en.irct. ir/trial/2019.

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Section: Discussionsupporting

confidence: 78%

Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial

et al. 2020

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“…Forouhi et al, [11] found that vitamin D deficiency affects kidney function. Previous studies reported the effects of vitamin D on glucose metabolism and indicated that the vitamin D level is controlled by various forms of VDRs in pancreatic ß-cells, skeletal muscle, and adipose tissue, which, in turn, may contribute to the genetic risk of type 2 diabetes [17,19] . Whether vitamin D deficiency is considered a risk factor in patients with DN remains unclear [11] .…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D deficiency plays a role in insulin resistance and the pathogenesis of type 2 diabetes mellitus [19] . Lower serum 25(OH)D concentrations are associated with higher risks for the development of type 2 diabetes mellitus [20] .…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D Receptor Gene Polymorphisms and Vitamin D Levels in Egyptian Patients with Diabetic Nephropathy and Type 2 Diabetes Mellitusus

Fathy¹,

tawfeek²,

Tawfeek³

2018

The Medical Journal of Cairo University

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Aim: Type 2 diabetes and diabetic nephropathy are associated with multiple genetic variables. This study aimed to investigate the role of the vitamin D receptor (VDR) BsmI gene polymorphism and the serum level of vitamin D in Egyptian patients with diabetic nephropathy and type 2 diabetes. Material and Methods: This study involved 80 patients with type 2 diabetes without nephropathy (T2DM), 80 patients with diabetic nephropathy (DN) and 100 healthy individuals as controls. VDR BsmI gene polymorphisms were determined by PCR-RFLP, and vitamin D serum levels were determined by the electrochemiluminescence binding assay. Results: The distribution frequencies of the Bb, bb and Bb+bb genotypes in patients with DN were significantly different from those in the controls (p<0.001) and in those with T2DM (p<0.001). In addition, the b allele frequency was significantly higher in the DN group than the healthy control (OR=6.3, 95% CI, 3.7-10.7, (p<0.001) and T2DM groups (OR=1.91, 95% CI 4.0-13.5, p<0.001). The patients with DN had significantly lower levels of serum vitamin D than both the healthy controls and T2DM patients (p<0.001). Using multivariate regression analysis, diabetes duration, HbA1C, vitamin D deficiency and BsmI genotype were found to be independent risk factors for DN (p=0.019, 0.036, 0.001, 0.035, respectively). Conclusion: The VDR BsmI gene polymorphism and vitamin D deficiency are risk factors for type 2 diabetes and diabetic nephropathy.

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“…Vitamin D was negatively correlated with fasting serum insulin and HOMA-IR (p<0.001). A study done by Zhang et al suggested that a low Vitamin D level is inversely related to HOMA-IR [35]. Studies done by Wher et al and Kumar et al showed the association of hypovitaminosis D with IR and obesity in women with PCOS [27,36].…”

Section: (Oh)mentioning

confidence: 99%

Role of Vitamin D in Etiopathogenesis and Metabolic Abnormalities Seen in Polycystic Ovarian Syndrome

Sukul

Bahinipati

Das

2019

Asian J Pharm Clin Res

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Objective: Polycystic ovarian syndrome (PCOS) is a common cause of ovarian dysfunction in women in reproductive age group. It is now the leading cause of infertility among premenopausal women. PCOS women usually suffer from metabolic disturbances and insulin resistance (IR). Vitamin D has shown a significant role in glucose and insulin metabolism. Correlation studies have been done to examine the role of vitamin D in PCOS. However, still, Vitamin D status in PCOS remains varied. This study is an attempt to find out the association of Vitamin D with etiopathogenesis and metabolic risk factors seen in PCOS. Methods: Hundred subjects (50 PCOS and 50 age-matched normal control) were recruited for the study. Difference in biochemical parameters in PCOS women and normal group was measured, and association of Vitamin D with etiological and biochemical parameters in PCOS was seen. Results: There was a significant (p<0.001) increase in body mass index, serum insulin, fasting blood sugar (FBS), serum cholesterol, triglyceride, and low-density lipoprotein in PCOS. IR was observed in PCOS cases (homeostatic model assessment for β-cell function and IR = 6.40±1.96) compared to the control group (2.43±0.53). Serum 25(OH) Vitamin D3 was significantly decreased in PCOS (9.04±2.60 ng/ml) compared to control group (20.06±3.28 ng/ml). Negative correlation of serum Vitamin D was found with FBS, serum insulin, IR, HI, and serum testosterone. Vitamin D with metabolic parameters also showed a statistically significant negative correlation. Conclusion: Vitamin D deficiency may be a common comorbid manifestation of PCOS. Hence, Vitamin D supplementation may decrease the potential risk of morbidity and mortality associated with PCOS. However, further studies are needed which should include assessment of Vitamin D in women at various stages of PCOS to enhance the temporal order of Vitamin D deficiency in relation to PCOS.

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Vitamin D Status Is Negatively Correlated with Insulin Resistance in Chinese Type 2 Diabetes

Cited by 41 publications

References 60 publications

Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial

Vitamin D supplementation improves SIRT1, Irisin, and glucose indices in overweight or obese type 2 diabetic patients: a double-blind randomized placebo-controlled clinical trial

Vitamin D Receptor Gene Polymorphisms and Vitamin D Levels in Egyptian Patients with Diabetic Nephropathy and Type 2 Diabetes Mellitusus

Role of Vitamin D in Etiopathogenesis and Metabolic Abnormalities Seen in Polycystic Ovarian Syndrome

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