Vitamin D Status, Insulin Resistance, Leptin-To-Adiponectin Ratio in Adolescents: Results of a 1-Year Lifestyle Intervention

Rambhojan, Christine; Larifla, Laurent; Clepier, Josiane; Bouaziz‐Amar, Elodie; Vélayoudom-Céphise, Fritz-Line; Blanchet-Deverly, Anne; Armand, C.; Plumasseau, Jean; Foucan, Lydia

doi:10.3889/oamjms.2016.131

Cited by 15 publications

(18 citation statements)

References 34 publications

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“…The results were converse to the results of most of the other studies. It seemed that 25(OH)D should have been lower in T2DM patients, and this finding was opposite to our results, since vitamin D deficiency may play a role in insulin resistance [25]. Thus, we hypothesized that vitamin D resistance existed in T2DM patients.…”

Section: Discussioncontrasting

confidence: 56%

The Relationship between Vitamin D and Type 2 Diabetes Is Intriguing: Glimpses from the Spect-China Study

Zheng²,

Wang³

et al. 2017

Ann Nutr Metab

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Objective: Vitamin D is a multifunctional vitamin for our body. Type 2 diabetes mellitus (T2DM) is a common metabolic disease. Whether T2DM affects the serum 25(OH)D level has not been reported. The objective of this study was to reveal the extent to which vitamin D is present in the population in East China and to explore the relationship between serum 25(OH)D and T2DM. Methods: The cohort was selected based on a large investigation named Survey on Prevalence in East China including 12,702 participants aged 21-92 years old. All the participants completed the questionnaire and went through a physical examination. Fasting blood samples were collected to test serum 25(OH)D and other metabolism-related indicators. AVONA was used to test the significance of differences among groups. Multinomial logistic regression was used to assess the association of T2DM with serum 25(OH)D level. Results: The overall percentage of vitamin D deficiency was 80.55% (male 74.1%, female 85.0%). Men with lower serum 25(OH)D level had high value in homeostasis model assessment of insulin resistance and HbA1c. The serum 25(OH)D level of those who were diagnosed with T2DM was higher than that in non-diabetics. The serum 25(OH)D level of pre-diabetes was the highest. T2DM patients trended to have higher serum 25(OH)D levels. Conclusion: Vitamin D deficiency is common among the people in East-China. T2DM patients had higher levels of serum 25(OH)D. The relationship between vitamin D and T2DM is intriguing. It seemed that vitamin D was either irrelevant directly to T2DM or resisted in T2DM patients.

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Section: Discussioncontrasting

confidence: 56%

The Relationship between Vitamin D and Type 2 Diabetes Is Intriguing: Glimpses from the Spect-China Study

Zheng²,

Wang³

et al. 2017

Ann Nutr Metab

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“…High leptin levels increase the expression of pro-inflammatory and pro-angiogenic cytokines [ 46 ]. However, vitamin D deficiency is associated with chronic inflammation and may predispose to insulin resistance [ 47 – 49 ].…”

Section: Discussionmentioning

confidence: 99%

Mother’s obesity and high child’s waist circumference are predictive factors of severe child’s obesity: an observational study in French Guiana

et al. 2018

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BackgroundThis study aims to describe the predictive factors of severe obesity in children followed in French Guiana.MethodsIn this observational study, the patients from the French Guianese Childhood Obesity Group database were prospectively included, after giving a statement of patient’s non opposition.ResultsOur group classifications revealed that 36 of 150 (24%) participants were classified as being metabolically abnormal obesity“ (MAO), while 114 of 150 (76%) were categorized as metabolically normal obesity” (MNO). MAO-patients were older. Their mothers had more severe obesity. We also observed that their systolic blood pressure was higher. The median Z-score BMI of children with MAO was 4, 9 [4, 05–5, 38], which shows a more obese condition than the MNO group. The median waist-to-height ratio (WTHR) of our study population was high, either 0.63 [0.54–0.59]. No significant differences in the term of pregnancy, father’s obesity, gender, birth weight, feeding, diastolic blood pressure and WTHR were found between the two groups. The predictors of MAO status, after adjusting for age and sex, were mother’s obesity and high child’s waist circumference.Among the comorbidity, there were two Down syndrome, one Cornelia de Lange syndrome, one Nephrotic Syndrome and one Epilepsy. The leptin hormone and insulin levels were higher in MAO than in MNO, while 25-OH D-vitamin was higher in MNO.ConclusionThis study indicates the need to incorporate waist circumference into routine clinical practice, in addition to traditional measures of weight, height, body mass index and waist-to-height ratio.

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“…Some studies show an increase in 25-OH vitamin D level after obtaining weight loss (16, 17). However, the possible causal nature of the correlation between body fat loss and increased serum 25 OH vitamin D level remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Is vitamin D deficiency in obese youth a risk factor for less weight loss during a weight loss program?

Maele

Schepper

Vanbesien

et al. 2019

Endocrine Connections

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BackgroundVitamin D deficiency is common in obese adolescents and a risk factor for insulin resistance. We investigated if prevailing serum 25-OH vitamin D might predict the body fat loss in a group of obese adolescents undergoing a residential weight loss program.MethodsIn 92 (35 male) obese adolescents (aged 10.6–19 years) undergoing a residential weight loss program in Belgium, fasting serum 25-OH vitamin D (25-OH-D), insulin, glucose and lipid levels were measured and body composition was assessed by dual-energy X-ray absorptiometry (DXA).ResultsBaseline median (range) serum 25-OH-D level was 17.7 µg/L (3.8–41.8). In total, 55 adolescents had a serum 25-OH-D below 20 µg/L. In 31 adolescents with a low baseline 25-OH-D level, median increase in serum 25-OH-D was 2.4 µg/L (−4.2 to 7.2) after 10 months. This resulted in normal 25-OH-D levels in seven adolescents, whereas median BMI decreased with 1.0 SDS and body fat percentage diminished with 9.9%. Obese adolescents with or without a 25-OH-D level below or above 20 µg/L at baseline had similar changes in body weight, BMI SDS, body fat percentage and body fat mass at the end of the program. The change in serum 25-OH-D did not correlate with change in serum insulin, BMI SDS or body fat percentage and body fat mass.ConclusionVitamin D deficiency was present in 55 out of 92 obese adolescents at the start of the summer. Serum 25-OH-D concentration did not predict changes in body fat loss after a residential weight loss program.

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Vitamin D Status, Insulin Resistance, Leptin-To-Adiponectin Ratio in Adolescents: Results of a 1-Year Lifestyle Intervention

Cited by 15 publications

References 34 publications

The Relationship between Vitamin D and Type 2 Diabetes Is Intriguing: Glimpses from the Spect-China Study

The Relationship between Vitamin D and Type 2 Diabetes Is Intriguing: Glimpses from the Spect-China Study

Mother’s obesity and high child’s waist circumference are predictive factors of severe child’s obesity: an observational study in French Guiana

Is vitamin D deficiency in obese youth a risk factor for less weight loss during a weight loss program?

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