Vitamin D status in women with pelvic floor disorders: A meta-analysis of observational studies

Ghanbari, Zinat; Karamali, Maryam; Mirhosseini, Naghmeh; Akbari, Maryam; Tabrizi, Reza; Lankarani, Kamran Bagheri; Eftekhar, Tahereh; Pesikhani, Maryam Deldar; Borzabadi, Shokoofeh; Asemi, Zatollah

doi:10.4103/jmh.jmh_9_19

Cited by 8 publications

(4 citation statements)

References 33 publications

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“…The role of Vitamin D can be promising in relapse prevention. Many studies have demonstrated a correlation between skeletal muscle weakness and low vitamin D concentrations, including an association with pelvic floor dysfunction, and a reduction in prolapse symptoms with vitamin D supplementation [12]. In this model, normalization of vitamin D3 levels reduces the chance of recurrence by a factor of 1.9 (95% CI: 0.747-0.945), which could affect connective tissue strength.…”

Section: Discussionmentioning

confidence: 98%

“…A recent meta-analysis found an effect of younger age and preoperative prolapse stage on recurrence [2], [10], [11]. Other sources point to smoking, body mass index (BMI), and a vegetarian diet as factors in relapse, and consumption of soy products and vaginal intercourse as protective factors against relapse [12]- [15]. Several studies have evaluated the relationship between vitamin D3 deficiency and pelvic floor dysfunction and the therapeutic effect of supplementation, but the role of vitamin deficiency on recurrence has not been indicated [16]- [21].…”

Section: Introductionmentioning

confidence: 99%

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Effect of diet, vitamin D3 and other factors on genital prolapse recurrensce

Laktionova,

Kulzhanov,

Imasheva

et al. 2024

IJPHS

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<p>This study addresses the pressing need for further investigation into risk factors contributing to genital prolapse recurrence, with a focus on factors like younger age and body mass index (BMI) that have been confirmed in the literature. Conducted as a cross-sectional study involving 300 post-operative cases of genital prolapse patients, the case groups comprising 210 individuals received regular gynecological check-ups every six months during the initial five years post-surgery, followed by annual visits, wherein lifestyle, diet, and laboratory values were monitored and adjusted. In contrast, the control group (90 patients) did not undergo post-operative gynecological follow-up. The results indicate that weight lifting, heavy physical work, menopause, constipation, insufficient protein intake, diseases associated with prolonged cough, and BMI are strongly associated with the likelihood of recurrent genital prolapse, while a weight reduction of 5 kg or more exhibits a protective effect (p<0.001). The established regression model proves statistically significant, explaining 84.1% of genital prolapse recurrence factors, with a sensitivity of 84.8% and specificity of 98.8%. These findings emphasize the importance of postoperative lifestyle monitoring, nutritional guidance, and immune support to reduce the risk of genital prolapse recurrence.</p>

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Effect of diet, vitamin D3 and other factors on genital prolapse recurrensce

Laktionova,

Kulzhanov,

Imasheva

et al. 2024

IJPHS

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“…[ 20 , 21 ] It has been shown in the literature that the prevalence of urinary incontinence is lower in patients with high vitamin D levels. [ 12 , 13 , 22 , 23 ] During the postpartum period, a significant decrease in pelvic floor muscle strength has been observed in patients with vitamin D deficiency. In addition, the incidence of UI was higher among women with vitamin D deficiency, although the difference was not statistical significance.…”

Section: Discussionmentioning

confidence: 99%

The effect of vitamin D deficiency on urinary incontinence during third trimester pregnancy

Gul,

Aydogmus,

Keles

et al. 2023

Medicine

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Urinary incontinence (UI) is a common problem which is associated with impaired quality of life. Vitamin D plays a crucial role for pelvic floor muscle function. The aim of this study was to investigate the effect of vitamin D deficiency on UI in pregnant women in the third trimester of pregnancy. All pregnant women at > 28 weeks of gestation who were followed in the gynecology and obstetrics outpatient clinic were screened. The patients were assessed for UI during routine follow-up. The Incontinence Severity Index was used to determine the severity of UI. A total of 210 patients were included as the study group and 40 patients were included as the control group. Both groups were compared based on the International Incontinence Severity Index scores. Of the patients, 40% had a history of UI and 84% had vitamin D deficiency. Pregnant women with vitamin D deficiency had statistically significant UI, compared to pregnant women in the control group. The severity of UI was also significantly higher in the patients with vitamin D deficiency. Urinary incontinence is significantly associated with vitamin D deficiency in pregnant women.

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“…44 A meta-analysis demonstrated lower levels of vitamin D in women with PFD than in healthy women. 45 The levator ani muscles of the pelvic floor are crucial in the control of urination via neural and mechanical pathways. 8 PFD could prevent closing of the urethra when intra-abdominal pressure increases, which is associated with UI.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review and Meta-Analysis of the Association between Vitamin D Status and Lower Urinary Tract Symptoms

Yuan

Wang

et al. 2021

Journal of Urology

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Purpose: Cumulative studies have shown that vitamin D may be associated with lower urinary tract symptoms but the findings have been inconsistent. The aim of this study was to systematically evaluate the relationship between vitamin D and lower urinary tract symptoms. Materials and Methods: The PubMedÒ, ScopusÒ and EmbaseÔ databases were searched for articles up to June 2020. A meta-analysis was conducted to evaluate the effects of vitamin D insufficiency or intake on lower urinary tract symptoms. A qualitative description summarized vitamin D intervention for treating lower urinary tract symptoms. Sensitivity analysis was conducted to examine heterogeneity and the robustness of the results. Results: A total of 23 studies including 86,332 participants were analyzed in our study. Vitamin D insufficiency was associated with a 1.37-fold to 2.06-fold increased likelihood of having lower urinary tract symptoms, and patients with lower urinary tract symptoms had significantly lower levels of vitamin D. Furthermore, vitamin D intake was significantly associated with an 11% reduction in the risk of lower urinary tract symptoms. In the subgroup analysis, the effects of vitamin D insufficiency on the risk of lower urinary tract symptoms were notably observed in nonAsians, females and patients with urinary incontinence. Conclusions: Consistent results indicated that vitamin D insufficiency was a crucial risk factor for lower urinary tract symptoms and that vitamin D supplementation showed promising effects on these symptoms. It would be of great guiding significance to consider vitamin D status when treating lower urinary tract symptoms.

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Vitamin D status in women with pelvic floor disorders: A meta-analysis of observational studies

Cited by 8 publications

References 33 publications

Effect of diet, vitamin D3 and other factors on genital prolapse recurrensce

Effect of diet, vitamin D3 and other factors on genital prolapse recurrensce

The effect of vitamin D deficiency on urinary incontinence during third trimester pregnancy

Systematic Review and Meta-Analysis of the Association between Vitamin D Status and Lower Urinary Tract Symptoms

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