Vitamin d status in TUNISIAN children with autism spectrum disorders

Chtourou, Mohamed; Naifar, Manel; Grayaa, Sahar; Hajkacem, I.; Touhemi, D. Ben; Ayadi, Fatma; Moalla, Y.

doi:10.1016/j.cca.2019.03.1296

Cited by 5 publications

(6 citation statements)

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“…In the control group, this deficiency was found in only about 57% [4]. Similar results were obtained by a team from the Department of Child Psychiatry in Tunisia, where research by Chtourou (2019), showed that over 60 % of autistic children had vitamin D deficiency [17]. During a one-year cohort study at a German Tertiary Care Hospital, almost 90% of the patients had vitamin D levels below reference [21].…”

Section: State Of the Knowledgesupporting

confidence: 77%

“…Vitamin D deficiency during the developing process of the brain can affect many signal pathways, such as neurotransmitter synthesis, differentiation of nerves cell, Ca2+-depending signalization, antioxidant activity, or mitochondrial activity. Both the vitamin D receptor and enzyme required to produce 1,25(OH)D are expressed in neurons and glial cells in the brain [10,16,17]. It is worth emphasizing that vitamin D-steroid hormon regulates about 3% of the genes in the coding genome [16].…”

Section: State Of the Knowledgementioning

confidence: 99%

“…During a one-year cohort study at a German Tertiary Care Hospital, almost 90% of the patients had vitamin D levels below reference [21]. Deficiency of this vitamin increases the risk of ASD more than 3 times [17]. Research by Ganta et al (2022) showed that as a result of limiting time spent away from home due to the COVID-19 pandemic, the risk of vitamin D deficiency significantly increased.…”

Section: State Of the Knowledgementioning

confidence: 99%

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Vitamin D deficiency as a risk factor for developing autism in childhood – literature review

Szumna,

Mitas,

Bartos

et al. 2023

J Pre Clin Clin Res.

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Introduction and Objective. Both autism and vitamin D deficiency are increasingly prevalent among children. Vitamin D is believed to play a key role in many developmental pathways. The aim of this study is to review current knowledge of the relationship between autism spectrum disease and vitamin D deficiency among the paediatric population. Review Methods. The review was performed using the PubMed and Cochrane database from the last 10 years. The terms 'autism' and 'vitamin D deficiency' were searched for. There were 15 articles in English on the PubMed database, 14 were included in the review. In the Cochrane database they were 16 position, 9 of which were included in the final analysis. Brief description of the state of knowledge. Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Typical signs are limited social relations, communication disorder and stereotyped and repetitive behaviours of varying severity. The etiology is still unknown, but nowadays the role of vitamin D deficiency isbeing investigated as a possible risk factor for ASD. There are many scientific reports of the mechanisms of action of vitamin D on the nervous system, as well as on the immune system and all cellular processes, which focus mainly on the regulation of calcium-depending systems, and antioxidant pathways. Vitamin D deficiency during pregnancy and early childhood can significantly affect the developing brain, predisposing to diseases such as autism and schizophrenia. Summary. Further research is still needed to determine the real impact of vitamin D deficiency on the risk of neurodevelopmental disorders, as well as the possibility of using supplementation as a form of treatment.

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Section: State Of the Knowledgesupporting

confidence: 77%

Section: State Of the Knowledgementioning

confidence: 99%

Section: State Of the Knowledgementioning

confidence: 99%

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Vitamin D deficiency as a risk factor for developing autism in childhood – literature review

Szumna,

Mitas,

Bartos

et al. 2023

J Pre Clin Clin Res.

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“…Lastly, 34 eligible articles (a total of 20,580 participants) were included in the meta-analysis. Of these, 26 case–control studies [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 34 , 35 , 36 , 37 , 48 , 49 , 50 ] (1792 ASDs, 1969 controls) reported the blood vitamin D concentration of children and adolescents; three case–control studies [ 42 , 43 , 51 ], and two nested case–control studies [ 38 , 40 ](2687 ASDs, 3574 controls) examined the neonatal vitamin D concentration of participants; one case–control study [ 52 ] and one nested case–control study [ 38 ] (517 ASDs, 642 controls) assessed maternal vitamin D concentration of the ASD and control groups; two cohort studies [ 39 , 41 ] (5442 neonates, 3957 pregnant women) investigated the OR/RR for ASD incidence after being exposed to early-life vitamin D deficiency or insufficiency. The participants of two articles included not only neonates but also pregnant women, so there were 36 total studies from 34 articles.…”

Section: Resultsmentioning

confidence: 99%

“…Besides the plausible biological explanations, some epidemiological studies also reached related conclusions. A large number of case–control studies investigating the vitamin D status of children and adolescents with ASD from different countries and races showed that autistic children and adolescents had lower vitamin D status [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ], but seven studies reached the opposite conclusions [ 32 , 33 , 34 , 35 , 36 , 37 ]. Moreover, several prospective studies investigated the role of maternal and neonatal vitamin D deficiency in autism onset.…”

Section: Introductionmentioning

confidence: 99%

The Association between Vitamin D Status and Autism Spectrum Disorder (ASD): A Systematic Review and Meta-Analysis

2020

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The association between vitamin D status and autism spectrum disorder (ASD) is well-investigated but remains to be elucidated. We quantitatively combined relevant studies to estimate whether vitamin D status was related to ASD in this work. PubMed, EMBASE, Web of Science, and the Cochrane Library were searched to include eligible studies. A random-effects model was applied to pool overall estimates of vitamin D concentration or odds ratio (OR) for ASD. In total, 34 publications involving 20,580 participants were identified in this present study. Meta-analysis of 24 case–control studies demonstrated that children and adolescents with ASD had significantly lower vitamin D concentration than that of the control group (mean difference (MD): −7.46 ng/mL, 95% confidence interval (CI): −10.26; −4.66 ng/mL, p < 0.0001, I2 = 98%). Quantitative integration of 10 case–control studies reporting OR revealed that lower vitamin D was associated with higher risk of ASD (OR: 5.23, 95% CI: 3.13; 8.73, p < 0.0001, I2 = 78.2%). Analysis of 15 case–control studies barring data from previous meta-analysis reached a similar result with that of the meta-analysis of 24 case–control studies (MD: −6.2, 95% CI: −9.62; −2.78, p = 0.0004, I2 = 96.8%), which confirmed the association. Furthermore, meta-analysis of maternal and neonatal vitamin D showed a trend of decreased early-life vitamin D concentration in the ASD group (MD: −3.15, 95% CI: −6.57; 0.26, p = 0.07, I2 = 99%). Meta-analysis of prospective studies suggested that children with reduced maternal or neonatal vitamin D had 54% higher likelihood of developing ASD (OR: 1.54, 95% CI: 1.12; 2.10, p = 0.0071, I2 = 81.2%). These analyses indicated that vitamin D status was related to the risk of ASD. The detection and appropriate intervention of vitamin D deficiency in ASD patients and pregnant and lactating women have clinical and public significance.

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Associations Between Vitamin D and Core Symptoms in ASD: An Umbrella Review

Jiang,

Dang,

Sui

et al. 2024

NDS

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We conducted an umbrella evaluation to quantitatively synthesize previous systematic reviews and meta-analyses, thereby collating evidence on the association between vitamin D and core symptoms in people with autism in anticipation of informing clinical vitamin D supplementation. Based on the pre-established protocol, we ended up with 9 studies. Based on rigorous analysis, we found that vitamin D deficiency early in life is a risk factor for the development of ASD and that vitamin D supplementation improves the core symptoms of ASD. Our study concludes that vitamin D supplementation is beneficial for individuals with autism, that vitamin D deficiency early in embryonic life increases the risk of ASD, and that our study supports the idea that prevention begins with vitamin D supplementation early in life. At the same time, we must recognize that our current conclusions support the benefits of vitamin D supplementation for children with ASD, but we are unable to determine the causal relationship, ie, how vitamin D works in ASD, and we need more basic research to explore the mechanisms involved.

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Vitamin d status in TUNISIAN children with autism spectrum disorders

Cited by 5 publications

References 0 publications

Vitamin D deficiency as a risk factor for developing autism in childhood – literature review

Vitamin D deficiency as a risk factor for developing autism in childhood – literature review

The Association between Vitamin D Status and Autism Spectrum Disorder (ASD): A Systematic Review and Meta-Analysis

Associations Between Vitamin D and Core Symptoms in ASD: An Umbrella Review

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