Vitamin D status in relation to systemic and intestinal inflammation in undernourished children, 6–59 months old: Design and rationale of a non-controlled open label trial

Carboo, Janet Adede; Malan, Linda; Lombard, Martani J; Dolman, Robin

doi:10.1016/j.hnm.2022.200181

Cited by 5 publications

(4 citation statements)

References 50 publications

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“…Though not statistically significant, supplementation with three doses of 50,000 IU of vitamin D produced encouraging increases in ferritin, BIS, and hemoglobin. 15 In Indonesia, Sunardi et al did study with 180 subjects. The average hemoglobin level was 11.4 ± 1.7 mg/dL, and 29.4% of the population had anemia.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Management of Iron Deficiency Anemia in Children: A Systematic Review

Poespo Koesoemo Aji,

Fabiola,

Andreuy Poespo Koesoemoadi

et al. 2024

JARMHS

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Background: Even in affluent nations, IDA is still a significant public health issue, particularly for young children and women who are ready to have children. Aims: This systematic review is to review the treatment and prevalence of iron deficiency anemia in children. Methods: This study demonstrated compliance with all requirements by means of a comparison with the standards established by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020. Thus, the specialists were able to guarantee that the research was as current as feasible. Publications released between 2014 and 2024 were considered for this search strategy. This was accomplished by utilizing a number of distinct online reference sites, including Pubmed, ScienceDirect, and SagePub. It was determined that reviews, previously published works, and partially completed works would not be included. Result: In the PubMed database, the results of our search brought up 353 articles, whereas the results of our search on SCIENCE DIRECT brought up 8.865 articles, our search on SAGEPUB brought up 3.269 articles. The results of the search conducted for the last year of 2014 yielded a total 184 articles for PubMed, 4.071 articles for SCIENCE DIRECT and 1.144 articles for SAGEPUB. In the end, we compiled a total of 5 papers, 3 of which came from PubMed, 1 of which came from SCIENCE DIRECT and 1 of which came from SAGEPUB. We included five research that met the criteria. Conclusion: In summary, with its haematological repercussions of anemia, IDA is a prevalent and significant children health concern. To assess the effects of IDA on immunity and neurocognition, additional research is necessary. The key to successfully treating children with IDA is early identification and diagnosis of the condition together with competent interpretation of laboratory tests.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Management of Iron Deficiency Anemia in Children: A Systematic Review

Poespo Koesoemo Aji,

Fabiola,

Andreuy Poespo Koesoemoadi

et al. 2024

JARMHS

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“…Recently, a review by Cho and colleagues showed that vitamin D supplementation has no clinical effect in the prevention of ARIs in the main analysis and subgroup analysis of high-quality studies [12], which was consistent with our study. Some reviews also explored the association between vitamin D supplementation in children and the risk of ARIs [13,14,43,44], all of them indicated…”

Section: Plos Onementioning

confidence: 99%

“…that vitamin D supplementation provided no benefit in preventing ARIs. However, two of these reviews showed high-dose vitamin D might reduce the incidence of influenza in children [13,14]. Another review also suggested that the most effective approach to optimizing and sustaining serum (25(OH)D) concentration throughout the year is by administering a significant bolus dose, followed by monthly or bi-monthly maintenance doses [45].…”

Section: Plos Onementioning

confidence: 99%

“…While some meta-analyses of the association between vitamin D supplementation and the risk of ARIs in the pediatric populations have been published [13,14], the efficacy of vitamin D supplementation in preventing ARIs in older adults remains uncertain and has not been thoroughly reviewed to the best of our knowledge. The number of older adults and adults with age-related chronic diseases is projected to more than double between 2019 and 2050 [15].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D supplementation for prevention of acute respiratory infections in older adults: A systematic review and meta-analysis

Jia,

Sheng,

Yan

et al. 2024

PLoS ONE

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Background Acute respiratory infections (ARIs) have a substantial impact on morbidity, healthcare utilization, and functional decline among older adults. Therefore, we systematically reviewed evidence from randomized controlled trials (RCTs) to evaluate the efficacy and safety of vitamin D supplementation in preventing ARIs in older adults. Methods PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov were searched until 1 February 2024. RCTs evaluating the use of vitamin D supplements to protect older adults from ARIs were included. Two reviewers independently screened papers, extracted the data and assessed the risk of bias. Data were summarised as relative risks (RRs) or odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Random effects meta-analyses were used to synthesise the results. GRADE was used to evaluate the quality of evidence. All the analysis were performed with Stata version 17. Results Twelve trials (41552 participants) were included in the meta-analysis. It showed that vitamin D supplementation probably does not reduce the incidence of ARIs (RR, 0.99; 95% CI, 0.97–1.02, I2 = 0%; moderate certainty). No significant effect of vitamin D supplementation on the risk of ARI was observed for any of the subgroups defined by baseline 25(OH)D concentration, control treatments, dose frequency, study duration, and participants’ condition. However, there was a possibility, although not statistically significant, that vitamin D may reduce the risk of ARI in patients with a baseline 25(OH)D concentration <50 nmol/L (OR, 0.90; 95% CI, 0.79–1.04, I2 = 14.7%). Additionally, vitamin D supplements might result in little to no difference in death due to any cause, any adverse event, hypercalcinemia, and kidney stones. Conclusions Vitamin D supplementation among older adults probably results in little to no difference in the incidence of ARIs. However, further evidence is needed, particularly for individuals with vitamin D deficiency and populations residing in low and middle income countries. Trial registration This study was registered on PROSPERO (CRD42023451265).

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The relationship between serum 25-hydroxyvitamin D and iron status and anaemia in undernourished and non-undernourished children under five years in South Africa

Carboo,

Dolman-Macleod,

Uyoga

et al. 2023

Human Nutrition & Metabolism

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Vitamin D status in relation to systemic and intestinal inflammation in undernourished children, 6–59 months old: Design and rationale of a non-controlled open label trial

Cited by 5 publications

References 50 publications

Prevalence and Management of Iron Deficiency Anemia in Children: A Systematic Review

Prevalence and Management of Iron Deficiency Anemia in Children: A Systematic Review

Vitamin D supplementation for prevention of acute respiratory infections in older adults: A systematic review and meta-analysis

The relationship between serum 25-hydroxyvitamin D and iron status and anaemia in undernourished and non-undernourished children under five years in South Africa

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