Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels

Marwaha, Raman K.; Tandon, Nikhil; Chopra, S. C.; Agarwal, Neha; Garg, Mahendra Kumar; Sharma, Bhu Dev; Kanwar, Ratnesh; Bhadra, Kuntal; Singh, Simar Rajan; Kalaivani, Mani; Puri, Seema

doi:10.1017/s000711451100170x

Cited by 116 publications

(86 citation statements)

References 55 publications

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“…Seventy-four percent of pregnant women had vitamin D deficiency. Marwaha et al [24] studied 541 apparently healthy women with uncomplicated, single, intrauterine gestation reporting in any trimester. Mean serum 25(OH)D of pregnant women was 23.2 (SD 12.2) nmol/l, hypovitaminosis D (25(OH)D < 50nmol/l) was observed in 96.3% of the subjects.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation in Pregnancy and Its Correlation with Fetomaternal Outcome

Swapna¹

2017

Ann Nutr Disord & Ther

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Vitamin D is known as Sunshine vitamin which mainly helps in bone metabolism. It is estimated that one billion people have vitamin D deficiency and it is considered as a public health problem. Preeclampsia and hypertensive disorders complicate 3-10% of pregnancies and contribute to maternal and neonatal morbidity and mortality [8]. Several studies have shown that women with preeclampsia have lower urinary calcium excretion, lower ionized calcium levels, higher Parathormone (PTH) levels and lower 1,25 dihydroxyvitamin levels compared with normotensive pregnant control subjects [9]. Patients with 25(OH)D levels <15ng/ml have a 5fold increase in the risk of preeclampsia, despite receiving prenatal vitamins [10]. Maternal vitamin D levels have been shown to positively correlate with birth weight centile [11]. Women with vitamin D deficiency have a 2.4 fold increased risk of having a small for gestational age baby [12]. Low vitamin D levels in late pregnancies were associated with reduced intrauterine long bone growth and lower gestational age at delivery [13].

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Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation in Pregnancy and Its Correlation with Fetomaternal Outcome

Swapna¹

2017

Ann Nutr Disord & Ther

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“…Marwaha et al reported that Serum 25(OH) D levels were significantly lower in winter in the second and third trimesters, while serum intact parathormone (iPTH) and alkaline phosphatase levels were significantly higher in winter in all three trimesters [25]. Similar to our study, Bodnar et In contrast, two studies found no differences in first or second trimester 25(OH) D between women at low or high risk for preeclampsia who did or did not develop the disorder later in pregnancy [28,29].…”

Section: Discussionmentioning

confidence: 99%

Elevated preeclampsia rates during winter with reduced sunlight dependent vitamin D production

Jain¹,

Sweety²,

Shuchi³

et al. 2016

Integr Food Nutr Metab

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Title: Preeclampsia rates are elevated during winter month when sunlight dependent vitamin D production is reduced. Aim: To assess maternal vitamin D deficiency in early pregnancy and risk of preeclampsia. Settings and Design:Nested case control study. Two maternal blood sample, one at <20 wks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=57) and control group (n=178) after abstracting past medical records at delivery. Methods and Material: Vitamin D was estimated by 25-Hydroxyvitamin D 125 I RIA Kit and categorized according to ACOG (2011) criteria. Statistical analysis used: Pearson χ 2 , ANOVA and logistic regression were used. Linear correlation and regression coefficient was used between maternal 25(OH) D at <20 wks and term and cord serum 25(OH)D levels. Results: serum 25(OH)D concentrations in early pregnancy were 56% significantly lower in women who subsequently developed preeclampsia compared with controls (mean, 9.79 ± 4.09 ng/ml , 95% CI, 8.71-10.88 ng/ml, vs. 22.26 ± 15.28 ng/ml and, 95%CI, 20.0-24.52 ng/ml; P<0.001) independent of age, BMI, calcium intake, socioeconomic status, periconceptional multivitamin use, residence. There was 17 times increased risk of preeclampsia in vitamin D deficient mothers compared to controls at early pregnancy and at term. (P<0.001; rr =17.93). Newborns of preeclamptic mothers were more than three times as likely as newborns of controls to have hypovitaminosis D(relative risk 3.55). Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is an independent risk factor for preeclampsia.

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“…This can be attributed to the fact that the prevalence of vitamin D deficiency is reported to be high during all three trimesters in pregnant women in India [8][9][10] and this could manifest in infants at birth and beyond. Some of the previous authors maintain that vitamin D deficiency in maternal blood correlated with that in cord blood [8].…”

Section: Citationmentioning

confidence: 99%

“…However, recent studies suggest that vitamin D deficiency is very common in apparently healthy individuals at all age groups and both genders in northern as well as southern India [5][6][7]. Limited data from northern India on vitamin D status in pregnant women in all 3 trimesters reveal unexpectedly high prevalence (74-98%) of hypovitaminosis D [8][9][10]. Zargar et al report that overall 76 (83%) of the subjects studied had vitamin D deficiency in Kashmir valley of Indian subcontinent [11].…”

Section: Introductionmentioning

confidence: 99%

Prevailing Serum Vitamin D Levels among Individuals in South Karnataka

M¹,

Lasrado²,

Sg³

et al. 2017

J Bioanal Biomed

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Introduction: Prevalence of vitamin deficiency is very high in India. The aim of the present study was to determine according to age groups, the status of vitamin D among individuals using samples received at clinical biochemistry laboratory. Materials and methods:The study population was grouped according to gender and age in decades. They were divided into three groups according to serum vitamin D status-NVD (normal serum vitamin D, >30 ng/ml), VDI (vitamin D insufficiency, 20-30 ng/ml), VDD (vitamin D deficiency, <20 ng/ml). Blood was collected in plain vacutainers and serum obtained was used for vitamin D estimation. Results were expressed as percentage of the sub-population in question.Results: Only 13% of the total study population was normal, 70% was vitamin D deficient and 17% showed vitamin D insufficiency. The prevalence of vitamin D deficiency was very high in all age groups and both genders. In all age groups, there were a higher percentage of females in the vitamin D insufficient and deficient groups. Males recorded higher prevalence of vitamin D deficiency in the 0-10 and 20-30 years age group while females recorded higher prevalence of the vitamin deficiency in the 20-30 years and 30-40 years age group Conclusion:The prevalence of vitamin D insufficiency and deficiency in the present study was high at all age groups and both genders. Further research needs to be conducted to correlate the changing dietary habits to the alterations in availability of 7-dehydrocholesterol for cutaneous biosynthesis of vitamin D.

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Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels

Cited by 116 publications

References 55 publications

Vitamin D Supplementation in Pregnancy and Its Correlation with Fetomaternal Outcome

Vitamin D Supplementation in Pregnancy and Its Correlation with Fetomaternal Outcome

Elevated preeclampsia rates during winter with reduced sunlight dependent vitamin D production

Prevailing Serum Vitamin D Levels among Individuals in South Karnataka

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